Integrated multistep flow synthesis

  1. Editor: Prof. Volker Hessel
    The University of Adelaide, Australia

This Thematic Series is inspired by the research on integrated multistep flow synthesis as proposed by the just started FET-OPEN ONE-FLOW project of EU.

The ONE-FLOW idea is to translate 'vertical hierarchy' of common multistep flow synthesis with its complex machinery (many serially connected reactors and separators; all being process controlled) into a self-organising 'horizontal hierarchy' of a compartmentalized flow reactor system - a biomimetic digital flow cascade machinery with just one reactor passage. Along those lines, this project aims to develop a digital flow cascade machinery which performs all the multiple reactions in one step, which includes inventing innovative catalytic cascades, and uplift that by enabling the best bio- and chemocatalysts working door by door.

  • Full Research Paper
  • Published 29 Nov 2017

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2017, 13, 2549–2560, doi:10.3762/bjoc.13.251

  • Review
  • Published 20 Feb 2018

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  • Supp. Info

Beilstein J. Org. Chem. 2018, 14, 470–483, doi:10.3762/bjoc.14.33

Continuous multistep synthesis of 2-(azidomethyl)oxazoles

  1. Thaís A. Rossa,
  2. Nícolas S. Suveges,
  3. Marcus M. Sá,
  4. David Cantillo and
  5. C. Oliver Kappe
  • Full Research Paper
  • Published 23 Feb 2018

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  • Supp. Info

Beilstein J. Org. Chem. 2018, 14, 506–514, doi:10.3762/bjoc.14.36

High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine

  1. Eric Yu,
  2. Hari P. R. Mangunuru,
  3. Nakul S. Telang,
  4. Caleb J. Kong,
  5. Jenson Verghese,
  6. Stanley E. Gilliland III,
  7. Saeed Ahmad,
  8. Raymond N. Dominey and
  9. B. Frank Gupton
  • Full Research Paper
  • Published 08 Mar 2018

Beilstein J. Org. Chem. 2018, 14, 583–592, doi:10.3762/bjoc.14.45

Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry

  1. Katharina Hiebler,
  2. Georg J. Lichtenegger,
  3. Manuel C. Maier,
  4. Eun Sung Park,
  5. Renie Gonzales-Groom,
  6. Bernard P. Binks and
  7. Heidrun Gruber-Woelfler
  • Full Research Paper
  • Published 19 Mar 2018

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Beilstein J. Org. Chem. 2018, 14, 648–658, doi:10.3762/bjoc.14.52

Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor

  1. Morten M. C. H. van Schie,
  2. Tiago Pedroso de Almeida,
  3. Gabriele Laudadio,
  4. Florian Tieves,
  5. Elena Fernández-Fueyo,
  6. Timothy Noël,
  7. Isabel W. C. E. Arends and
  8. Frank Hollmann
  • Letter
  • Published 26 Mar 2018

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  • Supp. Info

Beilstein J. Org. Chem. 2018, 14, 697–703, doi:10.3762/bjoc.14.58

Nanoreactors for green catalysis

  1. M. Teresa De Martino,
  2. Loai K. E. A. Abdelmohsen,
  3. Floris P. J. T. Rutjes and
  4. Jan C. M. van Hest
  • Review
  • Published 29 Mar 2018

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Beilstein J. Org. Chem. 2018, 14, 716–733, doi:10.3762/bjoc.14.61

Assessing the possibilities of designing a unified multistep continuous flow synthesis platform

  1. Mrityunjay K. Sharma,
  2. Roopashri B. Acharya,
  3. Chinmay A. Shukla and
  4. Amol A. Kulkarni
  • Review
  • Published 26 Jul 2018

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Beilstein J. Org. Chem. 2018, 14, 1917–1936, doi:10.3762/bjoc.14.166

  • Full Research Paper
  • Published 24 Aug 2018

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  • Supp. Info

Beilstein J. Org. Chem. 2018, 14, 2220–2228, doi:10.3762/bjoc.14.196

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