Genome mining in Trichoderma viride J1-030: discovery and identification of novel sesquiterpene synthase and its products

Scholarly Works

• Xu, Y.; Liu, C.; Qin, L.; Lv, B.; Zhang, G.; Li, C. Mining and engineering of terpene synthases and their applications in biomanufacturing. Chinese Journal of Chemical Engineering 2025, 86, 138–149. doi:10.1016/j.cjche.2025.08.001
• Jin, S.; Alberti, F. Advances in the discovery and study of Trichoderma natural products for biological control applications. Natural product reports 2025, 42, 1367–1386. doi:10.1039/d5np00017c
• Wang, Z.; Yu, J.; Wang, C.; Hua, Y.; Wang, H.; Chen, J. The Deep Mining Era: Genomic, Metabolomic, and Integrative Approaches to Microbial Natural Products from 2018 to 2024. Marine drugs 2025, 23, 261. doi:10.3390/md23070261
• Abe, T.; Taniguchi, T.; Ueda, D.; Abe, T.; Sato, T. Expanding the Diversity of the Terpene Skeleton and Structure through Identification of Noncanonical Class IE and IF Terpene Synthase-Formed Products. Organic letters 2025, 27, 6211–6215. doi:10.1021/acs.orglett.5c01879
• Yuan, G.-Y.; Zhang, J.-M.; Xu, Y.-Q.; Zou, Y. Biosynthesis and Assembly Logic of Fungal Hybrid Terpenoid Natural Products. Chembiochem : a European journal of chemical biology 2024, 25, e202400387. doi:10.1002/cbic.202400387
• Cong, Z.; Yin, Q.; Tian, K.; Mukoma, N. J.; Ouyang, L.; Hsiang, T.; Zhang, L.; Jiang, L.; Liu, X. Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases. Journal of fungi (Basel, Switzerland) 2024, 10, 350. doi:10.3390/jof10050350
• Cabanillas-Bojórquez, L. A.; Valdez-Baro, O.; Gutiérrez-Grijalva, E. P.; Heredia, J. B. Microbial Production of Bioactive Compounds. Interdisciplinary Biotechnological Advances; Springer Nature Singapore, 2023; pp 181–198. doi:10.1007/978-981-99-1737-2_10
• Li, C.-P.; Shi, Z.-Z.; Fang, S.-T.; Song, Y.-P.; Ji, N.-Y. Lipids and Terpenoids from the Deep-Sea Fungus Trichoderma lixii R22 and Their Antagonism against Two Wheat Pathogens. Molecules (Basel, Switzerland) 2023, 28, 6220. doi:10.3390/molecules28176220
• Sousa, T. F.; Vieira Reça, B. N. P.; Castro, G. S.; da Silva, I. J. S.; Caniato, F. F.; de Araújo Júnior, M. B.; Yamagishi, M. E. B.; Koolen, H. H. F.; Bataglion, G. A.; Hanada, R. E.; da Silva, G. F. Trichoderma agriamazonicum sp. nov. (Hypocreaceae), a new ally in the control of phytopathogens. Microbiological research 2023, 275, 127469. doi:10.1016/j.micres.2023.127469
• Ma, Z.-X.; Wang, S.-C.; Gu, X.-Y.; Wang, S.-L.; Hao, W.-J.; Jiang, B. Photocatalytic annulative cyanoalkyletherification of 1,6-enynes toward 1-indanones. Tetrahedron 2023, 139, 133438. doi:10.1016/j.tet.2023.133438
• Schalamun, M.; Schmoll, M. Trichoderma - genomes and genomics as treasure troves for research towards biology, biotechnology and agriculture. Frontiers in fungal biology 2022, 3, 1002161. doi:10.3389/ffunb.2022.1002161
• Sarrocco, S.; Vicente, I.; Staropoli, A.; Vinale, F. Genes Involved in the Secondary Metabolism of Trichoderma and the Biochemistry of These Compounds. Fungal Biology; Springer International Publishing, 2022; pp 113–135. doi:10.1007/978-3-030-91650-3_4
• Wang, T.; Yang, Y.; He, M.; Liu, M.; Huang, J.-W.; Min, J.; Chen, C.-C.; Liu, Y.; Zhang, L.; Guo, R.-T. Structural insights into the cyclization of unusual brasilane-type sesquiterpenes. International journal of biological macromolecules 2022, 209, 1784–1791. doi:10.1016/j.ijbiomac.2022.04.150
• Yuan, Y.; Cheng, S.; Bian, G.; Yan, P.; Ma, Z.; Dai, W.; Chen, R.; Fu, S.; Huang, H.; Chi, H.; Cai, Y.; Deng, Z.; Liu, T. Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi. Nature Catalysis 2022, 5, 277–287. doi:10.1038/s41929-022-00762-x
• Vicente, I.; Baroncelli, R.; Hermosa, R.; Monte, E.; Vannacci, G.; Sarrocco, S. Role and genetic basis of specialised secondary metabolites in Trichoderma ecophysiology. Fungal Biology Reviews 2022, 39, 83–99. doi:10.1016/j.fbr.2021.12.004
• Püth, N.; Ersoy, F.; Krings, U.; Berger, R. G. Sesquiterpene Cyclases from the Basidiomycete Cerrena unicolor. Catalysts 2021, 11, 1361. doi:10.3390/catal11111361
• Shenouda, M. L.; Cox, R. J. Molecular methods unravel the biosynthetic potential of Trichoderma species. RSC advances 2021, 11, 3622–3635. doi:10.1039/d0ra09627j
• Sato, H.; Hashishin, T.; Kanazawa, J.; Miyamoto, K.; Uchiyama, M. DFT Study of a Missing Piece in Brasilane-Type Structure Biosynthesis: An Unusual Skeletal Rearrangement. Journal of the American Chemical Society 2020, 142, 19830–19834. doi:10.1021/jacs.0c09616
• Feng, J.; Surup, F.; Hauser, M.; Miller, A.; Wennrich, J.-P.; Stadler, M.; Cox, R. J.; Kuhnert, E. Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase. Chemical communications (Cambridge, England) 2020, 56, 12419–12422. doi:10.1039/d0cc03950k

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