Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion

Scholarly Works

• Burchacka, E.; Pięta, P.; Pstrowska, K.; Korzenowska-Kowal, A.; Cieniuch, G.; Jewgiński, M. Novel strategies for inhibiting SufA protease: the role of ester substituents and biological properties. Future medicinal chemistry 2025, 17, 1827–1837. doi:10.1080/17568919.2025.2545173
• Arakcheev, A. V.; Grafov, O. Y.; Naumkin, A. V.; Raitman, O. A.; Martynov, A. G.; Gorbunova, Y. G.; Selektor, S. L. Langmuir-Blodgett nanoarchitectonics for photoinduced redox-isomeric transformations in lanthanide bis-phthalocyaninates at air/water and air/solid interfaces. Journal of colloid and interface science 2025, 700, 138470. doi:10.1016/j.jcis.2025.138470
• Schlosser, J.; Ihmels, H. Photocontrolled Binding of Styrylnaphthyridine Ligands to Abasic Site-Containing DNA by Reversible [2+2] Cycloaddition and Cycloreversion. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202400423. doi:10.1002/chem.202400423
• Dohmen, C.; Ihmels, H. Photoinduced [2+2] and [4+4] Cycloaddition and Cycloreversion Reactions for the Development of Photocontrollable DNA Binders. ChemPhotoChem 2024, 8. doi:10.1002/cptc.202300318
• Berdnikova, D. V. Aurones: Unexplored Visible-Light Photoswitches for Aqueous Medium. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202304237. doi:10.1002/chem.202304237
• Schlosser, J.; Fedorova, O.; Fedorov, Y.; Ihmels, H. Photoinduced in situ generation of DNA-targeting ligands: DNA-binding and DNA-photodamaging properties of benzo[c]quinolizinium ions. Beilstein journal of organic chemistry 2024, 20, 101–117. doi:10.3762/bjoc.20.11
• Schlosser, J.; Stötzel, N.; Fedorov, Y.; Ihmels, H. Photoinduced Reactions of Styrylpyridine Derivatives for the In Situ Formation of Selective Ligands for Apyrimidinic DNA. ChemPhotoChem 2023, 7. doi:10.1002/cptc.202300159
• Dohmen, C.; Ihmels, H. Switching between DNA binding modes with a photo- and redox-active DNA-targeting ligand, part II: the influence of the substitution pattern. Organic & biomolecular chemistry 2023, 21, 5799–5808. doi:10.1039/d3ob00879g
• Zhang, M.-s.; Chu, Y.; Wu, Z.; Guo, Y.-r.; Shi, Y.-n.; Wang, C.; Wang, M.-q.; Zhong, Y.-q.; Zhang, H.-y.; Wang, Y.-n.; Wang, J.; Zhao, G.-j. Ultrafast spectroscopic study on non-adiabatic UV protection mechanism of hemicyanines. Chinese Journal of Chemical Physics 2023, 36, 25–34. doi:10.1063/1674-0068/cjcp2104078
• Mizuno, K. Photochemistry of aromatic compounds (2019–2020). Photochemistry; The Royal Society of Chemistry, 2022; pp 125–200. doi:10.1039/9781839167676-00125
• Wang, Z.; Amjaour, H.; Robertson, J. E. M.; Azizov, D.; Ugrinov, A.; Chu, Q. R. A recyclable thermoset with built-in thermocleavable group developed from a cis-cyclobutane-1,2-dicarboxylic acid. Chemical communications (Cambridge, England) 2022, 58, 8850–8853. doi:10.1039/d2cc01502a
• Saifutiarova, A. E.; Fedorov, Y. V.; Maurel, F.; Gulakova, E. N.; Karnoukhova, V. A.; Fedorova, O. A. Highly regioselective and stereoselective photodimerization of azine-containing stilbenes in neat condition: An efficient synthesis of novel cyclobutanes with heterocyclic substituents. Journal of Photochemistry and Photobiology A: Chemistry 2022, 427, 113804. doi:10.1016/j.jphotochem.2022.113804
• Berdnikova, D. V. Photoswitches for controllable RNA binding: a future approach in the RNA-targeting therapy. Chemical communications (Cambridge, England) 2021, 57, 10819–10826. doi:10.1039/d1cc04241f
• Ramos-Soriano, J.; Galan, M. C. Photoresponsive Control of G-Quadruplex DNA Systems. JACS Au 2021, 1, 1516–1526. doi:10.1021/jacsau.1c00283
• Bosch, P.; Marcelo, G.; Matamoros-Recio, A.; Sucunza, D.; Mendicuti, F.; Domingo, A.; Vaquero, J. J. A new family of fluorescent pyridazinobenzimidazolium cations with DNA binding properties. Dyes and Pigments 2021, 192, 109443. doi:10.1016/j.dyepig.2021.109443
• Orehovec, I.; Matković, M.; Pehar, I.; Majhen, D.; Piantanida, I. Bis-Pyrene Photo-Switch Open- and Closed-Form Differently Bind to ds-DNA, ds-RNA and Serum Albumin and Reveal Light-Induced Bioactivity. International journal of molecular sciences 2021, 22, 4916. doi:10.3390/ijms22094916
• Bortolozzi, R.; Ihmels, H.; Schulte, R.; Stremmel, C.; Viola, G. Synthesis, DNA-binding and antiproliferative properties of diarylquinolizinium derivatives. Organic & biomolecular chemistry 2021, 19, 878–890. doi:10.1039/d0ob02298e
• Pithan, P. M.; Steup, S.; Ihmels, H. Cation-induced ring-opening and oxidation reaction of photoreluctant spirooxazine-quinolizinium conjugates. Beilstein journal of organic chemistry 2020, 16, 904–916. doi:10.3762/bjoc.16.82
• Berdnikova, D. V.; Heider, J.; Ihmels, H.; Sewald, N.; Pithan, P. M. Photoinduced release of DNA‐binding ligands from the [4+4] dimers of benzo[b]quinolizinium and anthracene derivatives. ChemPhotoChem 2020, 4, 520–525. doi:10.1002/cptc.202000015

Explore citations to this article at