Deoxygenative C2-heteroarylation of quinoline N-oxides: facile access to α-triazolylquinolines

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Department of Chemistry, Indian Institute of Technology Bombay, Powai-400076, Mumbai, India
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Associate Editor: L. Vaccaro
Beilstein J. Org. Chem. 2021, 17, 485–493. https://doi.org/10.3762/bjoc.17.42
Received 13 Jul 2020, Accepted 30 Jan 2021, Published 17 Feb 2021

Abstract

A metal- and additive-free, highly efficient, step-economical deoxygenative C2-heteroarylation of quinolines and isoquinolines was achieved from readily available N-oxides and N-sulfonyl-1,2,3-triazoles. A variety of α-triazolylquinoline derivatives were synthesized with good regioselectivity and in excellent yields under mild reaction conditions. Further, a gram-scale and one-pot synthesis illustrated the efficacy and simplicity of the developed protocol. The current transformation was also found to be compatible for the late-stage modification of natural products.

Introduction

Quinoline is a key heterocyclic moiety found in many natural products [1-4], agrochemicals and pharmaceuticals having potent biological activities, such as antimalarial, antibacterial and anticancer activities [5-11]. Due to their wide range of applications, selective functionalization of quinolines at various positions has gained significant interest in the last few years [12,13]. In particular, the C2-functionalization of quinolines has been well studied, and various methodologies were established for C–C [14-23], C–O [24,25] and C–S [26,27] bond formation. Recently C2-selective C–N bond formation has also attracted considerable attention due to the importance of the 2-aminoquinoline motif in medicinal chemistry and pharmaceuticals [28-45]. Some of the representative examples of biologically relevant derivatives containing a 2-aminoquinoline motif are shown in Figure 1 [46,47].

[1860-5397-17-42-1]

Figure 1: Bioactive molecules containing the 2-aminoquinoline motif.

As a result, a variety of transition metal-catalyzed C2-selective aminations of azine N-oxides were explored extensively [28-34]. Additionally, various transition metal-free C2-aminations of these scaffolds were also investigated [35-45]. For example, Yin and co-workers developed a protocol for the deoxygenative C2-amination of pyridine/quinoline N-oxides using t-BuNH2 and Ts2O/TFA in 2007 (Scheme 1a) [48].

[1860-5397-17-42-i1]

Scheme 1: C2-selective C–N bond formation of N-oxides.

Later, Londregan and co-workers were successful in achieving C2-amination employing secondary amines as the nucleophiles [49]. In their protocol, the regioselectivity is controlled by PyBroP catalyst, which acts as the N-oxide activator. Manley and Bilodeau reported the amidation of heterocyclic N-oxides at the C2-position using oxalyl chloride for activating the N-oxides [50]. In addition to amination and amidation, there are few reports on metal-free C2-heteroarylation of pyridine N-oxides. In 1984, Rogers demonstrated the synthesis of 2-triazolylpyridines from 2-azidopyridines and phenylacetylene [51]. Along the same lines, Keith reported methodologies for the C2-imidazolylation and triazolylation of various heterocyclic N-oxides using sulfuryldiimidazole and 1,2,4-triazole, respectively. However, their protocol affords a mixture of C2- and C4-heteroarylated products [52,53]. More recently, Muthusubramanian and co-workers further expanded the scope of Keith’s protocol to a variety of pyridine N-oxides [54]. Despite the versatility of these methods, the above reports involve the use of external additives for activating the N-oxides and suffer from other disadvantages, including prolonged reaction time, high temperature and limited substrate scope. At the same time, with the advent of Cu-catalyzed “Click” chemistry, N-sulfonyl-1,2,3-triazoles have become useful precursors for accessing a variety of heterocyclic moieties [55,56].

In spite of the above methods for the C2-amination, the establishment of a simple, efficient and atom-economical method for the synthesis of 2-triazolylquinoline derivatives is highly desired. The continuous interest and efforts of our group for the derivatization of quinoline moieties [57] and use of N-sulfonyl-1,2,3-triazoles as heterocyclic precursors encouraged us to develop a new strategy for the regioselective C2-triazolylation of quinoline N-oxide under mild reaction conditions (Scheme 1b) [58-62].

Results and Discussion

We initiated our trials employing easily accessible quinoline N-oxide (1a) and 1-tosyl-4-phenyl-1,2,3-triazole (2a) as model substrates. Subjecting the reaction mixture to 100 °C in the presence of DIPEA in 1,2-dichloroetane (DCE), we were pleased to observe the formation of C2-triazolylquinoline 3a selectively in 15% NMR yield (Table 1, entry 1). Replacing DIPEA with DABCO or K2CO3 did not further increase the yield of 3a (Table 1, entries 2 and 3). Interestingly, while doing the control studies to understand the role of the base, we found that the reaction indeed proceeds in the absence of the base to afford 3a in a better yield (40%, Table 1, entry 4). We further optimized the reaction conditions by lowering the temperature to 80 °C and then to 60 °C, which afforded 3a with a moderate yield increment up to 52% (Table 1, entries 5 and 6). However, when the reaction was performed at room temperature, surprisingly, the yield of 3a increased to 95% within 15 minutes (Table 1, entry 7). To examine the influence of solvent on the reaction, we screened other solvents, such as DCM, CHCl3 and toluene, which provided 3a only in inferior yields (Table 1, entries 8–10).

Table 1: Optimization of the reaction conditions.a

[Graphic 1]
entry solvent base T (°C) yield (%)b
1 DCE DIPEA 100 15
2 DCE DABCO 100 8
3 DCE K2CO3 100 <5
4 DCE 100 40
5 DCE 80 45
6 DCE 60 52
7 DCE rt 95 (92)c
8 DCM rt 78
9 chloroform rt 65
10 toluene rt 58

aReaction conditions: 0.1 mmol of 1a and 0.12 mmol of 2a in 1 mL solvent. bNMR yield was taken by using 0.1 mmol of 1,3,5-trimethoxybenzene as an internal standard. cYield of the isolated product in parentheses for 0.2 mmol 1a.

Using the optimized reaction conditions, we explored the substrate scope of our developed strategy using quinoline N-oxide (1a) with triazoles 2 having variable functional groups (Scheme 2). We examined the impact of electronic and steric effects of the substituents and observed that triazoles bearing electron-donating groups on the aromatic ring, such as alkyl or methoxy moieties, were well tolerated, furnishing the corresponding products 3bh in 83–95% yield. For electron-poor substituents (CF3 and F) on the aryl ring of the triazole, the corresponding products 3i and 3j were isolated in slightly lower yield (81% and 84%, respectively). Triazoles bearing halide substituents (Cl and Br) at the meta- or para-positions were also found to be viable substrates to afford the products 3k and 3l with 85–90% yield. Additionally, the reaction protocol is compatible with the heteroaromatic substrates and afforded 3m in 82% yield.

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Scheme 2: Substrate scope of N-sulfonyl-1,2,3-triazoles. Reaction conditions: 1a (0.2 mmol), 2 (0.24 mmol) and DCE (2 mL) at rt for 15–20 min.

Gratifyingly, alkenylated and aliphatic triazoles also showed similar reactivity and furnished desired products 3np in moderate yield (73–77%). Motivated by the above results, we further extended the scope of triazoles by using different heteroatom-tethered triazoles. The -O-, -S- and -N-linked triazoles smoothly reacted under standard reaction conditions to provide the corresponding functionalized C2-triazolylquinolines 3qx in 67–83% yield. Cyclohexadienone-tethered triazole afforded the corresponding product 3y in 66% yield. It is worth mentioning that when pyridine N-oxide was employed instead of 1a, only traces of the corresponding product were observed even after prolonged reaction time.

Subsequently, the substrate scope was evaluated by analyzing electronic and steric effects of substituents present on the quinoline N-oxides 1 (Scheme 3). Electronically rich Me and OMe groups at the 4- or 6-positions of N-oxides were tolerated and delivered the corresponding C2-triazolylquinolines 3z, 3aa and 3ab in 85–90% yield. Further, the structure was unambiguously confirmed by the single-crystal X-ray diffraction analysis of 3z [63]. Halogenated substrates also furnished the 2-heteroarylated products 3ac and 3ad in 81% and 77% yield, respectively. For 3-substituted quinoline N-oxides, a slight decrease in the yield to 70% was observed for 3ae. The 8-allylated quinoline N-oxide cleanly provided 3af in 84% yield.

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Scheme 3: Substrate scope of quinoline N-oxides. Reaction conditions: 1 (0.2 mmol), 2a (0.24 mmol) and DCE (2 mL) at rt for 15–20 min.

In addition, the compatibility of this transformation for late-stage modification of complex natural products was explored, and as shown in Scheme 4, the protocol was tested with various natural-product-derived triazoles. Novel C2-triazolyl products 4ac were synthesized in good yield of 61–70% from triazoles derived from thymol, cholesterol and vitamin E, respectively.

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Scheme 4: Late-stage modification of natural products.

To our delight, this protocol could also be extended for selective C1-functionalization of isoquinoline N-oxide (5, Scheme 5). Treating 5 with triazole 2a under standard reaction conditions, the C1-heteroarylated isoquinoline product 6a was obtained in 85% yield. Both the aromatic and aliphatic triazoles were suitable substrates for the reaction and afforded 6bd in good to excellent yield of 71–89%.

[1860-5397-17-42-i5]

Scheme 5: Substrate scope for the reaction of substituted triazoles with isoquinoline N-oxide.

In order to investigate the synthetic utility of the current methodology, a gram-scale reaction was carried out (Scheme 6a). Upon treating quinoline N-oxide (1a, 6.9 mmol, 1.0 g) with 4-phenyl-1-tosyl-1H-1,2,3-triazole (2a, 8.3 mmol, 1.2 equiv) at room temperature for 1 h, the reaction worked equally well and produced the desired product 3a in 87% yield (1.6 g). In addition, to enlarge the simplicity of the developed protocol for selective C2-triazolylation of quinoline derivatives, we performed a sequential one-pot synthesis by combining a Cu(I)-catalyzed “Click” reaction of phenylacetylene (7) with TsN3 and a metal-free C2-heteroarylation of quinoline N-oxide (1a, Scheme 6b). Remarkably, the yield of the desired product 3a in the one-pot synthesis (80%) was comparable to the stepwise pathway.

[1860-5397-17-42-i6]

Scheme 6: Gram-scale and one-pot synthesis.

The plausible mechanism for the C2-triazolylation of quinoline N-oxides is presented in Scheme 7 [64]. The reaction initiates by the nucleophilic attack of quinoline N-oxide, e.g., 1a, on the sulfonyl group of N-sulfonyl-1,2,3-triazole 2, leading to the formation of intermediate A. This on elimination of a free triazolyl anion generates intermediate B. In next step, the triazolyl anion attacks the electrophilic C2-position of the quinoline N-oxide, providing the intermediate C, which, upon rearomatization, affords the desired 2-triazolylquinoline product 3, along with the transfer of the oxygen atom from quinoline to the sulfonyl group of the triazole to form p-toluenesulfonic acid as the byproduct.

[1860-5397-17-42-i7]

Scheme 7: Proposed mechanism.

Conclusion

In summary, we have developed an operationally simple and metal-free protocol for the synthesis of α-triazolylquinolines utilizing N-sulfonyl-1,2,3-triazoles as the aminating source. The reaction proceeds at room temperature in a short reaction time with excellent regioselectivity. The methodology was also found to be compatible with isoquinoline N-oxides and diversely functionalized N-sulfonyl-1,2,3-triazoles to establish a broad substrate scope for a variety of scaffolds. The late-stage modification of natural products is the salient feature of this current transformation.

Experimental

General procedure for the C2-selective synthesis of α-triazolylquinolines 3

To an oven-dried reaction tube equipped with a magnetic stirring bar were added quinoline N-oxide (1a, 29 mg, 0.2 mmol, 1.0 equiv) and 4-phenyl-1-tosyl-1H-1,2,3-triazole (2a, 72 mg, 0.24 mmol, 1.2 equiv), followed by DCE (2 mL) via syringe. The reaction mixture was allowed to stir at rt for 15–20 min. After completion of the reaction, the solvent was evaporated under reduced pressure, and the residue was purified by column chromatography (ethyl acetate/petroleum ether 1:9) to get the desired product 3a in 92% yield (50 mg, 0.18 mmol).

Supporting Information

Supporting Information File 1: Experimental details.
Format: PDF Size: 5.5 MB Download

Funding

The activity was generously supported by Science and Engineering Research Board (SERB), India: CRG/2019/005059. G.S.S and R.S. would like to thank CSIR and UGC, India for the fellowships, respectively.

References

  1. Madapa, S.; Tusi, Z.; Batra, S. Curr. Org. Chem. 2008, 12, 1116–1183. doi:10.2174/138527208785740300
    Return to citation in text: [1]
  2. Michael, J. P. Nat. Prod. Rep. 2008, 25, 166–187. doi:10.1039/b612168n
    Return to citation in text: [1]
  3. Roughley, S. D.; Jordan, A. M. J. Med. Chem. 2011, 54, 3451–3479. doi:10.1021/jm200187y
    Return to citation in text: [1]
  4. Peng, H.-K.; Lin, C.-K.; Yang, S.-Y.; Tseng, C.-K.; Tzeng, C.-C.; Lee, J.-C.; Yang, S.-C. Bioorg. Med. Chem. Lett. 2012, 22, 1107–1110. doi:10.1016/j.bmcl.2011.11.121
    Return to citation in text: [1]
  5. Ridley, R. G. Nature 2002, 415, 686–693. doi:10.1038/415686a
    Return to citation in text: [1]
  6. Foley, M.; Tilley, L. Pharmacol. Ther. 1998, 79, 55–87. doi:10.1016/s0163-7258(98)00012-6
    Return to citation in text: [1]
  7. Solomon, V. R.; Lee, H. Curr. Med. Chem. 2011, 18, 1488–1508. doi:10.2174/092986711795328382
    Return to citation in text: [1]
  8. Garuti, L.; Roberti, M.; Pizzirani, D. Mini-Rev. Med. Chem. 2007, 7, 481–489. doi:10.2174/138955707780619626
    Return to citation in text: [1]
  9. Priya, N.; Gupta, A.; Chand, K.; Singh, P.; Kathuria, A.; Raj, H. G.; Parmar, V. S.; Sharma, S. K. Bioorg. Med. Chem. 2010, 18, 4085–4094. doi:10.1016/j.bmc.2010.04.011
    Return to citation in text: [1]
  10. Tseng, C.-H.; Chen, Y.-L.; Chung, K.-Y.; Wang, C.-H.; Peng, S.-I.; Cheng, C.-M.; Tzeng, C.-C. Org. Biomol. Chem. 2011, 9, 3205–3216. doi:10.1039/c0ob01225d
    Return to citation in text: [1]
  11. Gorka, A. P.; de Dios, A.; Roepe, P. D. J. Med. Chem. 2013, 56, 5231–5246. doi:10.1021/jm400282d
    Return to citation in text: [1]
  12. Iwai, T.; Sawamura, M. ACS Catal. 2015, 5, 5031–5040. doi:10.1021/acscatal.5b01143
    Return to citation in text: [1]
  13. Murakami, K.; Yamada, S.; Kaneda, T.; Itami, K. Chem. Rev. 2017, 117, 9302–9332. doi:10.1021/acs.chemrev.7b00021
    Return to citation in text: [1]
  14. Campeau, L.-C.; Stuart, D. R.; Leclerc, J.-P.; Bertrand-Laperle, M.; Villemure, E.; Sun, H.-Y.; Lasserre, S.; Guimond, N.; Lecavallier, M.; Fagnou, K. J. Am. Chem. Soc. 2009, 131, 3291–3306. doi:10.1021/ja808332k
    Return to citation in text: [1]
  15. Cho, S. H.; Hwang, S. J.; Chang, S. J. Am. Chem. Soc. 2008, 130, 9254–9256. doi:10.1021/ja8026295
    Return to citation in text: [1]
  16. Odani, R.; Hirano, K.; Satoh, T.; Miura, M. J. Org. Chem. 2015, 80, 2384–2391. doi:10.1021/acs.joc.5b00037
    Return to citation in text: [1]
  17. Xi, P.; Yang, F.; Qin, S.; Zhao, D.; Lan, J.; Gao, G.; Hu, C.; You, J. J. Am. Chem. Soc. 2010, 132, 1822–1824. doi:10.1021/ja909807f
    Return to citation in text: [1]
  18. Larionov, O. V.; Stephens, D.; Mfuh, A.; Chavez, G. Org. Lett. 2014, 16, 864–867. doi:10.1021/ol403631k
    Return to citation in text: [1]
  19. Ryu, J.; Cho, S. H.; Chang, S. Angew. Chem., Int. Ed. 2012, 51, 3677–3681. doi:10.1002/anie.201200120
    Return to citation in text: [1]
  20. Wu, J.; Cui, X.; Chen, L.; Jiang, G.; Wu, Y. J. Am. Chem. Soc. 2009, 131, 13888–13889. doi:10.1021/ja902762a
    Return to citation in text: [1]
  21. Cho, S. H.; Kim, J. Y.; Kwak, J.; Chang, S. Chem. Soc. Rev. 2011, 40, 5068–5083. doi:10.1039/c1cs15082k
    Return to citation in text: [1]
  22. Kumar, R.; Kumar, I.; Sharma, R.; Sharma, U. Org. Biomol. Chem. 2016, 14, 2613–2617. doi:10.1039/c5ob02600h
    Return to citation in text: [1]
  23. Kumar, R.; Kumar, R.; Dhiman, A. K.; Sharma, U. Asian J. Org. Chem. 2017, 6, 1043–1053. doi:10.1002/ajoc.201700267
    Return to citation in text: [1]
  24. Chen, X.; Zhu, C.; Cui, X.; Wu, Y. Chem. Commun. 2013, 49, 6900–6902. doi:10.1039/c3cc43947j
    Return to citation in text: [1]
  25. Lian, Y.; Coffey, S. B.; Li, Q.; Londregan, A. T. Org. Lett. 2016, 18, 1362–1365. doi:10.1021/acs.orglett.6b00295
    Return to citation in text: [1]
  26. Du, B.; Qian, P.; Wang, Y.; Mei, H.; Han, J.; Pan, Y. Org. Lett. 2016, 18, 4144–4147. doi:10.1021/acs.orglett.6b02289
    Return to citation in text: [1]
  27. Wu, Z.; Song, H.; Cui, X.; Pi, C.; Du, W.; Wu, Y. Org. Lett. 2013, 15, 1270–1273. doi:10.1021/ol400178k
    Return to citation in text: [1]
  28. Li, G.; Jia, C.; Sun, K. Org. Lett. 2013, 15, 5198–5201. doi:10.1021/ol402324v
    Return to citation in text: [1] [2]
  29. Li, G.; Jia, C.; Sun, K.; Lv, Y.; Zhao, F.; Zhou, K.; Wu, H. Org. Biomol. Chem. 2015, 13, 3207–3210. doi:10.1039/c5ob00135h
    Return to citation in text: [1] [2]
  30. Zhu, C.; Yi, M.; Wei, D.; Chen, X.; Wu, Y.; Cui, X. Org. Lett. 2014, 16, 1840–1843. doi:10.1021/ol500183w
    Return to citation in text: [1] [2]
  31. Yu, H.; Dannenberg, C. A.; Li, Z.; Bolm, C. Chem. – Asian J. 2016, 11, 54–57. doi:10.1002/asia.201500875
    Return to citation in text: [1] [2]
  32. Xie, L.-Y.; Peng, S.; Jiang, L.-L.; Peng, X.; Xia, W.; Yu, X.; Wang, X.-X.; Cao, Z.; He, W.-M. Org. Chem. Front. 2019, 6, 167–171. doi:10.1039/c8qo01128a
    Return to citation in text: [1] [2]
  33. Sun, K.; Wang, X.; Liu, L.; Sun, J.; Liu, X.; Li, Z.; Zhang, Z.; Zhang, G. ACS Catal. 2015, 5, 7194–7198. doi:10.1021/acscatal.5b02411
    Return to citation in text: [1] [2]
  34. Dhiman, A. K.; Chandra, D.; Kumar, R.; Sharma, U. J. Org. Chem. 2019, 84, 6962–6969. doi:10.1021/acs.joc.9b00739
    Return to citation in text: [1] [2]
  35. Li, P.; Zhao, J.; Xia, C.; Li, F. Org. Chem. Front. 2015, 2, 1313–1317. doi:10.1039/c5qo00204d
    Return to citation in text: [1] [2]
  36. Aithagani, S. K.; Kumar, M.; Yadav, M.; Vishwakarma, R. A.; Singh, P. P. J. Org. Chem. 2016, 81, 5886–5894. doi:10.1021/acs.joc.6b00593
    Return to citation in text: [1] [2]
  37. Bering, L.; Antonchick, A. P. Org. Lett. 2015, 17, 3134–3137. doi:10.1021/acs.orglett.5b01456
    Return to citation in text: [1] [2]
  38. Chen, X.; Cui, X.; Yang, F.; Wu, Y. Org. Lett. 2015, 17, 1445–1448. doi:10.1021/acs.orglett.5b00330
    Return to citation in text: [1] [2]
  39. Xia, H.; Liu, Y.; Zhao, P.; Gou, S.; Wang, J. Org. Lett. 2016, 18, 1796–1799. doi:10.1021/acs.orglett.6b00522
    Return to citation in text: [1] [2]
  40. Tang, R.-J.; Kang, L.; Yang, L. Adv. Synth. Catal. 2015, 357, 2055–2060. doi:10.1002/adsc.201500268
    Return to citation in text: [1] [2]
  41. Couturier, M.; Caron, L.; Tumidajski, S.; Jones, K.; White, T. D. Org. Lett. 2006, 8, 1929–1932. doi:10.1021/ol060473w
    Return to citation in text: [1] [2]
  42. Xie, L.-Y.; Peng, S.; Liu, F.; Yi, J.-Y.; Wang, M.; Tang, Z.; Xu, X.; He, W.-M. Adv. Synth. Catal. 2018, 360, 4259–4264. doi:10.1002/adsc.201800918
    Return to citation in text: [1] [2]
  43. Xie, L.-Y.; Peng, S.; Lu, L.-H.; Hu, J.; Bao, W.-H.; Zeng, F.; Tang, Z.; Xu, X.; He, W.-M. ACS Sustainable Chem. Eng. 2018, 6, 7989–7994. doi:10.1021/acssuschemeng.8b01358
    Return to citation in text: [1] [2]
  44. Chen, X.; Peng, M.; Huang, H.; Zheng, Y.; Tao, X.; He, C.; Xiao, Y. Org. Biomol. Chem. 2018, 16, 6202–6205. doi:10.1039/c8ob00862k
    Return to citation in text: [1] [2]
  45. Londregan, A. T.; Jennings, S.; Wei, L. Org. Lett. 2011, 13, 1840–1843. doi:10.1021/ol200352g
    Return to citation in text: [1] [2]
  46. Clark, D. E.; Higgs, C.; Wren, S. P.; Dyke, H. J.; Wong, M.; Norman, D.; Lockey, P. M.; Roach, A. G. J. Med. Chem. 2004, 47, 3962–3971. doi:10.1021/jm040762v
    Return to citation in text: [1]
  47. Smith, A. L.; DeMorin, F. F.; Paras, N. A.; Huang, Q.; Petkus, J. K.; Doherty, E. M.; Nixey, T.; Kim, J. L.; Whittington, D. A.; Epstein, L. F.; Lee, M. R.; Rose, M. J.; Babij, C.; Fernando, M.; Hess, K.; Le, Q.; Beltran, P.; Carnahan, J. J. Med. Chem. 2009, 52, 6189–6192. doi:10.1021/jm901081g
    Return to citation in text: [1]
  48. Yin, J.; Xiang, B.; Huffman, M. A.; Raab, C. E.; Davies, I. W. J. Org. Chem. 2007, 72, 4554–4557. doi:10.1021/jo070189y
    Return to citation in text: [1]
  49. Londregan, A. T.; Jennings, S.; Wei, L. Org. Lett. 2010, 12, 5254–5257. doi:10.1021/ol102301u
    Return to citation in text: [1]
  50. Manley, P. J.; Bilodeau, M. T. Org. Lett. 2002, 4, 3127–3129. doi:10.1021/ol0264556
    Return to citation in text: [1]
  51. Rogers, R. B.; Gerwick, B. C.; Egli, E. A. 1-(Pyridyl)-1H-1,2,3-triazole derivatives, and use as herbicidal agents. U.S. Patent US4474599A, Oct 2, 1984.
    Return to citation in text: [1]
  52. Keith, J. M. J. Org. Chem. 2008, 73, 327–330. doi:10.1021/jo702038g
    Return to citation in text: [1]
  53. Keith, J. M. J. Org. Chem. 2010, 75, 2722–2725. doi:10.1021/jo1001017
    Return to citation in text: [1]
  54. Harisha, M. B.; Nagaraj, M.; Muthusubramanian, S.; Bhuvanesh, N. RSC Adv. 2016, 6, 58118–58124. doi:10.1039/c6ra10452e
    Return to citation in text: [1]
  55. Chattopadhyay, B.; Gevorgyan, V. Angew. Chem., Int. Ed. 2012, 51, 862–872. doi:10.1002/anie.201104807
    Return to citation in text: [1]
  56. Davies, H. M. L.; Alford, J. S. Chem. Soc. Rev. 2014, 43, 5151–5162. doi:10.1039/c4cs00072b
    Return to citation in text: [1]
  57. Shukla, R. K.; Nair, A. M.; Khan, S.; Volla, C. M. R. Angew. Chem., Int. Ed. 2020, 59, 17042–17048. doi:10.1002/anie.202003216
    Return to citation in text: [1]
  58. Dey, A.; Thrimurtulu, N.; Volla, C. M. R. Org. Lett. 2019, 21, 3871–3875. doi:10.1021/acs.orglett.9b01392
    Return to citation in text: [1]
  59. Nallagonda, R.; Thrimurtulu, N.; Volla, C. M. R. Adv. Synth. Catal. 2018, 360, 255–260. doi:10.1002/adsc.201701162
    Return to citation in text: [1]
  60. Thrimurtulu, N.; Dey, A.; Maiti, D.; Volla, C. M. R. Angew. Chem., Int. Ed. 2016, 55, 12361–12365. doi:10.1002/anie.201604956
    Return to citation in text: [1]
  61. Sontakke, G. S.; Pal, K.; Volla, C. M. R. J. Org. Chem. 2019, 84, 12198–12208. doi:10.1021/acs.joc.9b01924
    Return to citation in text: [1]
  62. Pal, K.; Sontakke, G. S.; Volla, C. M. R. Org. Lett. 2019, 21, 3716–3720. doi:10.1021/acs.orglett.9b01174
    Return to citation in text: [1]
  63. Supplementary crystallographic data for this paper can be obtained free of charge from the Cambridge Crystallographic Data Centre using the associated CCDC numbers via http://www.ccdc.cam.ac.uk/data_request/cif. CCDC 1986151 (3z).
    Return to citation in text: [1]
  64. Dong, H.; Zhang, D.; Fang, R.; Du, Q.; Dong, Z.; Wei, H.; Shi, M.; Wang, F. Synth. Commun. 2018, 48, 1227–1234. doi:10.1080/00397911.2018.1440316
    Return to citation in text: [1]
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