Supporting Information
| Supporting Information File 1: 1H, 13C, and 32P NMR spectra for all new compounds, HPLC charts and MALDI–TOF mass data for all new oligonucleotides, UV melting curves of the duplexes formed between GuNA[Me]-modified oligonucleotides and ssDNAs (or ssRNAs), and CD spectra of ON4/ssRNA and ON4/ssDNA. | ||
| Format: PDF | Size: 2.3 MB | Download |
Cite the Following Article
Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases
Naohiro Horie, Takao Yamaguchi, Shinji Kumagai and Satoshi Obika
Beilstein J. Org. Chem. 2021, 17, 622–629.
https://doi.org/10.3762/bjoc.17.54
How to Cite
Horie, N.; Yamaguchi, T.; Kumagai, S.; Obika, S. Beilstein J. Org. Chem. 2021, 17, 622–629. doi:10.3762/bjoc.17.54
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 8.7 MB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Islam, M. A.; Obika, S. Bridged Nucleic Acids for Therapeutic Oligonucleotides. Handbook of Chemical Biology of Nucleic Acids; Springer Nature Singapore, 2023; pp 497–542. doi:10.1007/978-981-19-9776-1_18
- Yamaguchi, T.; Horie, N.; Aoyama, H.; Kumagai, S.; Obika, S. Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N'- methylguanidine-bridged nucleic acids. Nucleic acids research 2023, 51, 7749–7761. doi:10.1093/nar/gkad608
- Islam, M. A.; Obika, S. Bridged Nucleic Acids for Therapeutic Oligonucleotides. Handbook of Chemical Biology of Nucleic Acids; Springer Nature Singapore, 2022; pp 1–46. doi:10.1007/978-981-16-1313-5_18-1
- Gong, Y.; Zhang, W.; Chen, L.; Lin, R.; Zhou, R.; Salter, R. Nitro-Activated Nucleobase Exchange in the Synthesis of 2'-Fluoro-2'-Deoxyribonucleosides. The Journal of organic chemistry 2022, 87, 9330–9342. doi:10.1021/acs.joc.2c01093
Patents
- BEIGELMAN LEONID; RAJWANSHI VIVEK KUMAR; ELTEPU LAXMAN; MONTERO SAUL MARTINEZ; HONG JIN. MODIFIED GAPMER OLIGOMERS AND METHODS OF USE THEREOF. WO 2023177808 A1, Sept 21, 2023.
