2 article(s) from Bizdēna, Ērika
- Full Research Paper
- Published 11 Feb 2021
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Scheme 1: Synthetic pathways for the synthesis of 6-substituted 2-triazolylpurine derivatives IV.
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Scheme 2: Synthesis of 2,6-bistriazolylpurine derivatives 2a–c.
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Scheme 3: Synthesis of 6-alkyloxy-2-triazolylpurine derivatives 3a–f.
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Scheme 4: Synthesis of 6-alkyloxy-2-triazolylpurine nucleosides 3g–j.
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Scheme 5: 2,6-Bistriazolylpurine derivatives in SNAr reactions with H2O/HO− as nucleophiles.
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Scheme 6: Synthesis of C6-substituted 2-triazolylpurine derivatives 5.
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Figure 1: Possible tautomeric structures of compounds 5a–d.
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Synthesis and fluorescent properties of N(9)-alkylated 2-amino-6-triazolylpurines and 7-deazapurines
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- Published 15 Feb 2019
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Figure 1: Examples of fluorescent purine/7-deazapurine derivatives.
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Scheme 1: General synthetic routes for the compounds 5, 7–9, 10 and 11. Method A: alkyl halogenide, MeCN or D...
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Figure 2: 1H NMR spectra of compound 6b in CD3CN at different temperatures (300 MHz, c = 12.5 mg/mL); a, b, c...
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Figure 3: Comparison of 1H NMR spectra of compounds 8a and 5 (300 MHz, CDCl3).
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Figure 4: a) Experimental UV–vis absorption spectra (lines) with computed theoretical absorption bands (colum...
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Figure 5: Photos of compound 8c (A and B) and compound 11c (C and D) in THF, CHCl3, DMSO, MeCN and MeOH befor...
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Figure 6: a) Fluorescence spectra of compounds 8c (λexc = 360 nm) and 11c (λexc = 370 nm) in solvents of diff...
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Figure 7: Energy diagram for the frontier molecular orbitals of compounds 8a, 8c, 11a and 11c.
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Figure 8: Labeled MCF-7 cells using compound 9 (C,D) and unlabeled MCF-7 cells (A,B) in microscope (2 h, c(9)...
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