4 article(s) from Bracher, Franz
- Full Research Paper
- Published 26 Sep 2019
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Figure 1: Marine pyridoacridine alkaloids amphimedine (1), ascididemin (2), kuanoniamine A (3), styelsamine D...
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Figure 2: A–C): Published methods for the synthesis of 4,5-disubstituted benzo[c][2,7]naphthyridines; D) New ...
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Scheme 1: Regioselective metalation of 4-bromobenzo[c][2,7]naphthyridine (9d) and subsequent conversion into ...
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Scheme 2: Outcome of a D2O quenching experiment after metalation of 4-bromobenzo[c][2,7]naphthyridine (9d).
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Scheme 3: Synthesis of 5-substituted 4-bromobenzo[c][2,7]naphthyridines via regioselective metalation of 9d u...
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Scheme 4: Attempted synthesis of kuanoniamine A (3).
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Scheme 5: Synthesis of pyrido[4,3,2-mn]acridone 22 starting from 20a via bromine–magnesium exchange reaction ...
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- Full Research Paper
- Published 02 Sep 2019
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Figure 1: Atorvastatin calcium trihydrate (1) and previously published decomposition products arising from tr...
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Scheme 1: Formation of novel artefacts 6 and 7 under extremely strong acidic conditions.
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Figure 2: Top: Molecular structure of artefact 6. Shown here is the molecular structure of one of three indep...
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Figure 3: Separation of atorvastatin (1; retention time: 5.8 min) from the four decomposition products 2 (ret...
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Scheme 2: Proposed mechanism for the formation of desamidated product 7.
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Scheme 3: Proposed mechanism for the formation of bridged product 6 under cyclization, isopropyl migration an...
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- Full Research Paper
- Published 11 Jan 2018
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Figure 1: Previously published total syntheses of alkaloid 1 [11,12].
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Scheme 1: Total synthesis of alkaloid 1 via direct ring metalation and methylation.
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Scheme 2: Total synthesis of alkaloid 1 via the aminomethyl intermediate 5 and selectivity’s found in debenzy...
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- Full Research Paper
- Published 08 Aug 2017
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Figure 1: Prominent oxoaporphine and oxoisoaporphine alkaloids: liriodenine (1), menisporphine (2), dauriporp...
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Scheme 1: Previously reported [7,17] and new approach to oxoisoaporphine alkaloids.
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Scheme 2: Synthesis of iodinated isoquinolines 8a–c from alkoxy-substituted isoquinolines 7a–c.
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Scheme 3: Synthesis of methyl 2-(isoquinolin-1-yl)benzoates 10a–c from 1-iodoisoquinolines 8a–c.
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Scheme 4: Synthesis of the alkaloids 6-O-demethylmenisporphine (4), dauriporphinoline (5), and bianfugecine (6...
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Scheme 5: Attempted synthesis of bianfugecine (6) via directed remote metalation and subsequent trapping of t...
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Scheme 6: Outcome of a D2O quenching experiment after metalation of amide 12.
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Scheme 7: Synthesis of 1-arylnaphthalene analogues 15 and 16.
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Scheme 8: Outcome of a D2O quenching experiment after metalation of amide 16 with LDA.
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Scheme 9: Synthesis of the alkaloids menisporphine (2) and dauriporphine (3) by O-methylation of the alkaloid...
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