2 article(s) from Dernedde, Jens
- Full Research Paper
- Published 13 May 2015
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Scheme 1: Protein design and dual-functionalization of TTL: periodate cleavage, oxime ligation and CuAAC.
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Figure 1: Dual-functionalization of TTL: A) MALDI–MS spectra (red: modified protein (as marked below); black:...
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Figure 2: SPR measurements: A) set-up showing different binding events of the double-functionalized TTL to EC...
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- Full Research Paper
- Published 05 May 2015
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Scheme 1: General approach to divalent or trivalent carbohydrate mimetics on the basis of aminopyran 1 or ser...
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Scheme 2: Hydroxy group protection of aminopyran 1 to give compound 3, synthesis of amide 4 and subsequent de...
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Scheme 3: Attempt to synthesize protected divalent compound 6. Conditions: a) succinic acid dichloride, Et3N,...
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Scheme 4: HATU-mediated synthesis of divalent amide 25 and trivalent amides 27 and 29. Conditions: a) HATU, Et...
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Scheme 5: Polysulfations of amides 5 and 13. Conditions: a) 1) SO3∙DMF, DMF-d7, 1 d, rt; 2) 1 M NaOH, 0 °C; 3...
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Scheme 6: Polysulfation of divalent amides 21 and 22 leading to tetrasulfated amides 32 and 33. Conditions: a...
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Scheme 7: Conversion of trivalent compound 27 into nonasulfated carbohydrate mimetic 34. Conditions: a) 1) SO3...
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Figure 1: Structures of O-sulfated divalent amide 32 and trivalent amide 34 and their respective IC50 values ...
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