5 article(s) from Flitsch, Sabine L
- Full Research Paper
- Published 22 Sep 2015
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Figure 1: Library generation of P450cam[Tyr96Phe]-RhFRed. Active site of the P450cam-RhFRed variant Tyr96Phe ...
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Figure 2: Radar plots illustrating the substrate acceptance of P450cam-RhFRed variants from library I. Colour...
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Figure 3: Yields of alcohols (R,S)-9-11 (grey bars) and ketone products 13–15 (blue bars) in sub-pools of lib...
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- Full Research Paper
- Published 21 May 2012
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Figure 1: Carbohydrate arrays on polystyrene slides can be obtained by noncovalent immobilisation of tritylat...
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Scheme 1: Synthesis of the tritylated compounds 3 [28], 5 and 7: (a) dichloromethane, 2.5 h, rt, 98%, (b) HBTU/DI...
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Figure 2: Comparison of the polystyrene and glass surfaces with and without aluminium backing by matrix-free ...
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Scheme 2: The Man–Trt compound 5 forms the disulfide 8 during UV ionisation in MALDI-TOF MS analysis.
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Figure 3: Limit-of-detection analysis of 5 on aluminium-backed glass and polystyrene slides. Both systems sho...
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Figure 4: Comparison of MALDI-TOF MS spectra on the aluminium-backed polystyrene and glass slides after washi...
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Figure 5: Photo of the aluminium strip on the back of the polystyrene support.
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- Full Research Paper
- Published 03 Apr 2012
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Scheme 1: Regioselective hydroxylation of Cbz-piperidine by Rhodococcus rhodochrous resting cells.
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Scheme 2: Results from the incubation of THP ether derivatives with Rhodococcus rhodochrous showing the isola...
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Scheme 3: Influence of substrate structure and linker length on the regioselectivity of hydroxylation.
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Scheme 4: Regioselective hydroxylation following incubation of THF ether derivatives with Rhodococcus rhodoch...
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- Full Research Paper
- Published 02 Nov 2011
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Figure 1: Oxidation reactions with P450cam-RhFRed mutants.
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Scheme 1: Whole cell biotransformation of diphenylmethane to 4-hydroxydiphenylmethane with P450cam(Y96A)-RhFR...
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- Full Research Paper
- Published 29 Jul 2010
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Figure 1: Aminoethyl glycosides (1–9) which were synthesised in this study.
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Scheme 1: General reaction scheme for generation of aminoethyl glycosides. X = OAc, Br or Cl.
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Scheme 2: Deprotection protocols.
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