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Beilstein J. Org. Chem. 2026, 22, 948–954, doi:10.3762/bjoc.22.74
Graphical Abstract
Scheme 1: Synthesis of aminodioxolanes 4a,b. TMG = 1,1,3,3-tetramethylguanidine.
Scheme 2: Acid-catalyzed heterocyclization of β-aminoketones 4a,b with diethyl and dipropyl ketones.
Scheme 3: Synthesis of piperidine nitroxides from piperidines 5a,b and organometallic reagents.
Scheme 4: Hydrogenation of carbon–carbon multiple bonds of nitroxides 7a–d.
Scheme 5: Sequential hydrogenation and dioxolane deprotection.