3 article(s) from Leumann, Christian J
Chemical structure of selected fluorine-modified nucleic acids.
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Synthesis of the bicyclic nucleoside 6. Reagents and conditions: a) BSA, thymine, NIS, DCM, 0 °C to...
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Synthesis of the thymidine phosphoramidite building block 9. Reagents and conditions: a) HF-pyridin...
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X-ray structure of nucleoside 6a (left) and 6b (right).
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a) Potential energy profile versus pseudorotation phase angle of nucleoside 7 and b) its minimal en...
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CD spectra of ON1–4 with complementary a) DNA, and b) RNA. Total strand conc. 2 μM in 10 mM NaH2PO4...
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Hydrolysis products of the RNase H activation assay. The DNA served as positive control, whereas C1...
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Beilstein J. Org. Chem. 2019, 15, 79–88, doi:10.3762/bjoc.15.9
Chemical structure of selected nucleic acid analogs.
Synthesis of the gem-difluorinated glycal 4 from the silyl enol ethers 1α/β. Reagents and condition...
Synthesis of the thymidine phosphoramidite building block 10. Reagents and conditions: a) i) thymin...
Synthesis of the cytidine phosphoramidite building block 16. Reagents and conditions: a) Ac2O, pyri...
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Proposed mechanism for the formation of the 5’-phosphorylated fragments during the oxidation step i...
a) Potential energy profile versus pseudorotation phase angle of nucleoside 8 and its two minimal e...
Average structures of the a) 6’F-bc4,3-DNA/DNA, b) 6’F-bc4,3-DNA/RNA, and c) 6’F-bc4,3-DNA/6’F-bc4,3...
Preferred sugar pucker of a) 6’F-bc4,3-DNA/DNA, and b) 6’F-bc4,3-DNA/RNA duplexes and torsion angle...
Beilstein J. Org. Chem. 2018, 14, 3088–3097, doi:10.3762/bjoc.14.288
Chemical structures and carbon numbering scheme of tricyclo(tc)-DNA (top, left), bicyclo(bc)-DNA (t...
Conditions: (a) NaBH4, CeCl3·7H2O, MeOH, −78 °C → rt, 1.5 h, 73% (+9% of C6-epimer); (b) TBS-Cl, im...
Conditions: (a) thymine, BSA, TMSOTf, TMSCl, CH3CN, rt, 2.5 h; (b) DMTrCl, pyridine, rt, 16 h, 29% ...
X-ray structure of top row: nucleosides 8β (left), 11β (center) and overlay of both structures (rig...
Pathways for elimination of the modified nucleotides during the oxidation step in oligonucleotide a...
Beilstein J. Org. Chem. 2014, 10, 1840–1847, doi:10.3762/bjoc.10.194
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