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Beilstein J. Org. Chem. 2025, 21, 1126–1134, doi:10.3762/bjoc.21.90
Graphical Abstract
Figure 1: (A) Position numbering on the pyrazine ring of 1,2,4-triazolo[4,3-a]pyrazine. (B) Illustration of i...
Scheme 1: Treatment of 1 with phenethylamine (PEA) under two different reaction conditions, (i) or (ii), gave ...
Figure 2: Key COSY (–), HMBC (→) and ROESY (↔) correlations for compound 2.
Figure 3: Thermal ellipsoid plot of compound 2.
Scheme 2: Chemical structures, reagents and conditions used to synthesise the new aminated triazolopyrazines 2...
Figure 4: Thermal ellipsoid plots for compounds 7 (A), 10 (B) and 15 (C).
Beilstein J. Org. Chem. 2023, 19, 107–114, doi:10.3762/bjoc.19.11
Scheme 1: Synthesis of ether triazolopyrazine derivatives 4–9.
Scheme 2: Synthesis of fluorinated triazolopyrazine compounds (10–18) via Diversinate™ chemistry.
Figure 1: Key HMBC, COSY and ROESY correlations, and ORTEP drawing of 18.
Beilstein J. Org. Chem. 2022, 18, 1544–1552, doi:10.3762/bjoc.18.164
Figure 1: UHPLC–UV chromatogram (254 nm) of the CH2Cl2/MeOH extract of Ianthella basta (NB6021519); retention...
Figure 2: Chemical structures of 5-debromopurealidin H (1) and ianthesine E (2).
Figure 3: Key COSY, HMBC and ROESY correlations for 5-debromopurealidin H (1).
Figure 4: Chemical structures of the NatureBank bromotyrosine derivatives: psammaplysins F (3) and H (4), bas...
Figure 5: Dose-response assessment of in vitro activity of compounds 1–9 against exsheathed third-stage larva...