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Beilstein J. Org. Chem. 2025, 21, 1018–1023, doi:10.3762/bjoc.21.83
Graphical Abstract
Figure 1: Compound 1 and 2.
Figure 2: Chiral ligands 3–7.
Scheme 1: Preparation and optical resolution of 7.
Scheme 2: Pd-catalyzed asymmetric allylic amination of acetate 12 (Ar = Ph) or 15 (Ar = p-ClC6H4) with isatin...
Scheme 3: Transformation of the reaction product (S)-13a: The reaction was carried out at 0.1 mmol scale and ...
Beilstein J. Org. Chem. 2025, 21, 547–555, doi:10.3762/bjoc.21.43
Figure 1: Selected examples and applications of chiral halogen-bonding catalysts.
Figure 2: Selected examples for the construction of contiguous tetrasubstituted carbon centers via the Mannic...
Scheme 1: Catalyst screening for the asymmetric Mannich reaction. All yields were determined by 1H NMR spectr...
Scheme 2: N-Protecting group optimization for the asymmetric Mannich reaction. All yields were determined by 1...
Scheme 3: Catalyst screening using 7b as a substrate. All yields were determined by 1H NMR spectroscopy using...
Scheme 4: Substrate scope for the asymmetric Mannich reaction using 0.06 mmol of 7. Isolated product yields a...
Figure 3: Plausible reaction mechanism.