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1 article(s) from Pathak, Biswarup

Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation

Premansh Dudhe,
Mena Asha Krishnan,
Kratika Yadav,
Diptendu Roy,
Krishnan Venkatasubbaiah,
Biswarup Pathak and
Venkatesh Chelvam

Beilstein J. Org. Chem. 2021, 17, 1453–1463, doi:10.3762/bjoc.17.101

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Figure 1: Selected examples of compounds containing the γ-carboline core.

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Scheme 1: The synthetic strategy of present work in comparison with previous reports.

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Scheme 2: Series of synthesized 1-indolyl-3,5,8-substituted γ-carboline 3aa–ac, 3ba-ea and 1-indolyl-1,2-dihy...

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Figure 2: Single-crystal XRD structure of 3ac (CCDC: 1897787).

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Scheme 3: Plausible mechanism for the formation of 1,2-dihydro-γ-carboline derivative 3ga and 1-indolyl-3,5,8...

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Figure 3: UV–vis absorption (left side) and emission (right side) spectra of 3ac measured in different solven...

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Figure 4: Fluorescence decay profile of 3ac in DMSO (left side; λ_ex 360 nm) and 10⁻⁵ M solutions of compound ...

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Figure 5: Dose–response curves for (A) γ-carbolines 3ac, 3bc, 3ca, 3ga in the breast cancer cell line, MCF7 a...

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Figure 6: Dose–response curve of γ-carbolines 3ac, 3bc, 3ca, 3ga in macrophage cell line, RAW264.7.

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Figure 7: Laser scanning confocal microscopy studies (λ_ex = 405 nm; collection range = 420–470 nm) for uptake...

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Published 17 Jun 2021

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