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3 article(s) from Shishkina, Svitlana V.

Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide–alkyne cycloaddition

Maryna O. Mazur,
Oleksii S. Zhelavskyi,
Eugene M. Zviagin,
Svitlana V. Shishkina,
Vladimir I. Musatov,
Maksim A. Kolosov,
Elena H. Shvets,
Anna Yu. Andryushchenko and
Valentyn A. Chebanov

Full Research Paper
Published 08 Mar 2021

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1. Graphical Abstract
2. Figure 1: Benzodiazepine-based azolo-containing drugs.
  
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3. Figure 2: Novel potential 1,2,3-triazolobenziadiazepine drugs.
  
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4. Scheme 1: Examples of synthesis of 1,2,3-triazolobenzodiazepines via tandem approach Ugi reaction/IAAC. Reage...
  
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5. Scheme 2: Azide precursor synthesis.
  
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6. Scheme 3: Synthesis of Ugi products 6, their structures and yields.
  
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7. Figure 3: Code legend for Ugi products 6 and molecular structure (X-ray analysis) of compound 6aaa.
  
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8. Scheme 4: Cyclization of Ugi-product 6aab with terminal alkyne fragment.
  
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9. Figure 4: ¹H NMR spectra of the reactant and the product of IAAC.
  
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10. Figure 5: Molecular structure of compound 7aaa (X-ray analysis) and comparison of ¹H NMR spectra of compounds ...
  
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11. Scheme 5: The substrate scope of intermolecular cycloaddition.
  
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Graphical Abstract

Beilstein J. Org. Chem. 2021, 17, 678–687, doi:10.3762/bjoc.17.57

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In water multicomponent synthesis of low-molecular-mass 4,7-dihydrotetrazolo[1,5-a]pyrimidines

Irina G. Tkachenko,
Sergey A. Komykhov,
Vladimir I. Musatov,
Svitlana V. Shishkina,
Viktoriya V. Dyakonenko,
Vladimir N. Shvets,
Mikhail V. Diachkov,
Valentyn A. Chebanov and
Sergey M. Desenko

Full Research Paper
Published 08 Oct 2019

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1. Graphical Abstract
2. Scheme 1: Three synthetic approaches to dihydrotetrazolo[1,5-a]pyrimidines.
  
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3. Scheme 2: Three-component reaction of 1, 7a,b and 8a–d in water.
  
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4. Figure 1: Molecular structure of 9a according to X-ray data. Displacement ellipsoids are shown at the 50% pro...
  
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5. Scheme 3: Three-component reaction of 5-aminotetrazole (1) with formaldehyde (7a) and acetylacetone (10).
  
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6. Scheme 4: a) Three-component reaction of 5-aminotetrazole (1) with acetaldehyde (7b) and ethyl 4,4,4-trifluor...
  
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Beilstein J. Org. Chem. 2019, 15, 2390–2397, doi:10.3762/bjoc.15.231

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Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

Sergii V. Melnykov,
Andrii S. Pataman,
Yurii V. Dmytriv,
Svitlana V. Shishkina,
Mykhailo V. Vovk and
Volodymyr A. Sukach

Full Research Paper
Published 07 Dec 2017

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1. Graphical Abstract
2. Figure 1: Summary of the present study.
  
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3. Scheme 1: Hydrogenation of compounds 4–6 and preparation of N1(3)-unsubstituted compounds 9–11d.
  
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4. Figure 2: Molecular structure of compound 11b. Two enantiomers form a heterochiral dimer in the crystal state...
  
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Beilstein J. Org. Chem. 2017, 13, 2617–2625, doi:10.3762/bjoc.13.259

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