2 article(s) from Suresh, Rajendran
- Full Research Paper
- Published 31 Aug 2020
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Figure 1: Examples of biologically active oxazole and aminothiazole scaffolds.
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Scheme 1: Strategies for the synthesis of 2,4,5-trisubstituted oxazole from azirine. a) I2, PPh3; b) NaH, 1H-...
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Scheme 2: Scope of the α-azidochalcones. The reactions were carried out at reflux temperature, using 1 (1 mmo...
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Scheme 3: Large-scale synthesis of 3i.
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Figure 2: Large-scale synthesis of 3i. a) At the start of the reaction, b) after the reaction.
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Scheme 4: Acetyl derivative of 3d.
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Figure 3: ORTEP diagram of compound 5.
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Scheme 5: Synthesis of S-methyl/benzylated products 6 and 7.
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Scheme 6: Control experiments.
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Scheme 7: Plausible mechanism proposed for the formation of 2,4,5-trisubstituted oxazoles 3.
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Scheme 8: Reaction of vinyl azide 1 and 3 with ferric nitrate. Reactions were carried out at reflux temperatu...
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Figure 4: X-ray crystal structure of 4h.
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- Full Research Paper
- Published 29 Oct 2015
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Graphical Abstract
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Figure 1: Formation of substituted aziridine.
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Figure 2: Various strategies for the formation of 2H-azirine.
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Scheme 1: Attempted reaction for the synthesis of 3a.
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Figure 3: Synthesis of α-amido-1,3-diketone (3a–o). Reaction conditions: α-azidochalcone 1 (1.0 equiv) and ca...
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Scheme 2: Plausible mechanism.
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Scheme 3: Attempted reaction with acid derivatives.
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Scheme 4: Oxazole formation from 3.
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Figure 4: Possible isomers for 7.
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Scheme 5: Oxazole formation.
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Figure 5: Synthesis of highly substituted 2-(trifluoromethyl)oxazoles (8a–e). Reaction conditions: α-azidocha...
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Scheme 6: Mechanism for the formation of 8.
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