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Beilstein J. Org. Chem. 2025, 21, 1964–1972, doi:10.3762/bjoc.21.152
Graphical Abstract
Scheme 1: Representative prostaglandins and general synthetic strategy toward PGDM methyl ester 4.
Scheme 2: Retrosynthetic analysis for the first generation synthesis of PGDM methyl ester 4.
Scheme 3: Synthesis of bicyclic ketal 25.
Scheme 4: Retrosynthetic analysis for the second-generation synthesis of tricyclic PGDM methyl ester 4.
Scheme 5: Asymmetric total synthesis of tricyclic-PGDM methyl ester 4.
Beilstein J. Org. Chem. 2025, 21, 839–844, doi:10.3762/bjoc.21.67
Scheme 1: Copper-catalyzed cascade reaction of 2-halobenzoic acids and amidines for the synthesis of quinazol...
Scheme 2: Substrate scope. Reaction conditions: 1 (0.5 mmol, 1.0 equiv), amidines hydrochloride 2 (0.75 mmol,...
Scheme 3: Proposed mechanism for the CS@CuI-catalyzed synthesis of quinazolinones.
Scheme 4: Scaling-up experiment (a) and recyclability of CS@CuI (b).
Beilstein J. Org. Chem. 2015, 11, 2007–2011, doi:10.3762/bjoc.11.217
Scheme 1: Standard reaction conditions.
Scheme 2: Formation of aliphatic chiral β-hydroxy nitrile 2g and its subsequent conversion into 4g.