Continuous flow based catch and release protocol for the synthesis of α-ketoesters

• Alessandro Palmieri,
• Steven V. Ley,
• Anastasios Polyzos,
• Mark Ladlow and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2009, 5, No. 23, doi:10.3762/bjoc.5.23

• process is tolerant of both aliphatic and aromatic substituted nitro-derivatives in the first step, and accommodates ester, acetate, acetal, nitrile and olefinic functionality in the final product. The process was reliable over several runs and consistently afforded very clean material (≥ 97% by NMR). The

A convenient synthesis of γ-functionalized cyclopentenones

• Nour Lahmar,
• Taïcir Ben Ayed,
• Moncef Bellassoued and
• Hassen Amri

Beilstein J. Org. Chem. 2005, 1, No. 11, doi:10.1186/1860-5397-1-11

•  1). Various synthetic methods were developed to obtain 1,4-diketones [16][17][18][19][20] since these compounds were valuable intermediates in the synthesis of cyclopentenone ring system. Obviously the most straightforward route was the Nef reaction. The transformation of the nitro derivatives to