Large- scale ruthenium- and enzyme- catalyzed dynamic kinetic resolution of (rac)-1-phenylethanol

• Krisztián Bogár,
• Belén Martín-Matute and
• Jan-E. Bäckvall

Beilstein J. Org. Chem. 2007, 3, No. 50, doi:10.1186/1860-5397-3-50

• mixture afforded enantiopure acetate 3 in 97% yield after 20 h. Careful analysis of the enantiomeric purity of acetate 3 revealed that it was >99.8% ee. This result is remarkable since only a very low catalyst loading is employed and in addition, only 150 mL of toluene as the solvent is used to produce