Beilstein J. Org. Chem.2012,8, 428–432, doi:10.3762/bjoc.8.48
partly to the content of ManNAc. Thus, ManNAc units play a significant role in bacterial pathogenicity and virulence (e.g., Streptococcus pneumoniae) [4][5]. Surprisingly, glycosidases active upon β-ManpNAc and α-ManpNAc glycosides are not known so far. Therefore, the building blocks for the chemical
Beilstein J. Org. Chem.2010,6, No. 52, doi:10.3762/bjoc.6.52
heterocycles which exhibit a wide range of biological activities. Many phenazine compounds are found in nature and are produced by bacteria such as Pseudomonas spp., Streptomyces spp. and Pantoea agglomerans. These phenazine natural products have been implicated in the virulence and competitive fitness of the
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Graphical Abstract
Scheme 1:
Synthetic plan towards quinoxaline derivatives.