Heteroannulations of cyanoacetamide-based MCR scaffolds utilizing formamide

• Marios Zingiridis,
• Danae Papachristodoulou,
• Despoina Menegaki,
• Konstantinos G. Froudas and
• Constantinos G. Neochoritis

Beilstein J. Org. Chem. 2025, 21, 217–225, doi:10.3762/bjoc.21.13

• specific MCR-based scaffolds as precursors and employing the abundant and inexpensive formamide as a C1 feedstock under neat conditions, we were able to efficiently access substituted thieno-, quinolino- and indolopyrimidones without the need of column chromatography. Further, a single-crystal X-ray

Hydrogen-bonded macrocycle-mediated dimerization for orthogonal supramolecular polymerization

• Wentao Yu,
• Zhiyao Yang,
• Chengkan Yu,
• Xiaowei Li and
• Lihua Yuan

Beilstein J. Org. Chem. 2025, 21, 179–188, doi:10.3762/bjoc.21.10

• effectively applied to form orthogonal supramolecular polymers. The macrocycle-mediated connectivity was confirmed by single-crystal X-ray diffraction, which revealed a unique 2:2 binding motif between host and guest, bridged by two cationic pyridinium end groups through π-stacking interactions and other

• 2444.3405, respectively. Stacked 1H NMR spectra (CDCl3/CD3CN 1:1, v/v, 400 MHz, 298 K) of G1 upon addition of different equiv of H1 ([G1] = 1.0⋅10−3 M). (a) 0.0 equiv, (b) 0.2 equiv, (c) 0.4 equiv, (d) 0.6 equiv, (e) 0.8 equiv, (f) 1.0 equiv, (g) 1.2 equiv, (h) 1.4 equiv, and (i) only H1. Single-crystal X

• -ray structure of the complex H2 ⊃ G1. a) Dimeric structure formed by cyclo[6]aramide H2 and cationic guest G1, with each guest molecule threading one molecule of H2 at its end. b) A portion of the dimeric structure showing an array of hydrogen bonding interactions between the amide oxygen atoms of H2

Synthesis, structure and π-expansion of tris(4,5-dehydro-2,3:6,7-dibenzotropone)

• Yongming Xiong,
• Xue Lin Ma,
• Shilong Su and
• Qian Miao

Beilstein J. Org. Chem. 2025, 21, 1–7, doi:10.3762/bjoc.21.1

• analysis of it with X-ray crystallography. Interestingly, it is observed that tris(4,5-dehydro-2,3:6,7-dibenzotropone) crystallized from its solution in hexane resulting in colorless and yellow crystal polymorphs, where it adopts conformations of approximate Cs and C2 symmetry, respectively. Furthermore

•  1) featuring three heptagons and two pentagons, with its structure confirmed by X-ray crystallography. This π-expansion approach of compound 1 differs from the method reported by Müllen and co-workers, which involves Ramirez olefination and Suzuki coupling, resulting in the expansion of a seven

• Scholl reaction conditions. The structure of 3 was confirmed with single crystal X-ray crystallography, as detailed later. In addition, another product with a molecular ion peak of 1695.9115 in the high-resolution mass spectrum (Supporting Information File 1, Figure S6) was isolated in trace amounts

Synthesis, characterization, and photophysical properties of novel 9‑phenyl-9-phosphafluorene oxide derivatives

• Shuxian Qiu,
• Duan Dong,
• Jiahui Li,
• Huiting Wen,
• Jinpeng Li,
• Yu Yang,
• Shengxian Zhai and
• Xingyuan Gao

Beilstein J. Org. Chem. 2024, 20, 3299–3305, doi:10.3762/bjoc.20.274

• HRMS spectrometry were in full agreement with the expected structures, and single-crystal X-ray diffraction analysis was conducted to confirm the structure of compound 7-H. Moreover, the photophysical properties of these PhFlOP derivatives were determined by UV–vis absorption and photoluminescence

• fully elucidated by single-crystal X-ray crystallography, which was performed on a Bruker APEX-II CCD diffractometer using graphite monochromated Mo Kα radiation at a temperature of 296 ± 2 K. Crystallographic data were deposited with the Cambridge Crystallographic Data Centre under accession number

• simple. The structure of 7-H was confirmed by single-crystal X-ray diffraction. Furthermore, UV–vis absorption and PL studies were carried out to explore the photophysical properties of these PhFlOP derivatives. Investigations for further applications of the PhFlOP-based emitters 7 are still ongoing. An

Reactivity of hypervalent iodine(III) reagents bearing a benzylamine with sulfenate salts

• Beatriz Dedeiras,
• Catarina S. Caldeira,
• José C. Cunha,
• Clara S. B. Gomes and
• M. Manuel B. Marques

Beilstein J. Org. Chem. 2024, 20, 3281–3289, doi:10.3762/bjoc.20.272

• benziodoxolone, 2d) were obtained with quantitative yields, as white solids on the gram-scale, easy to manipulate and long-term stable below 0 °C. Crystals of compound 2d were successfully obtained and its molecular structure was confirmed through single-crystal X-ray diffraction. The X-ray analysis revealed a

• the electrophilic amination of tert-butyl 3-(p-tolylsulfinyl)propanoate (4a) with BBX 2a (0.23 mmol of limitant in 2 mL of solvent). Supporting Information Supporting Information File 54: Experimental procedures, characterization data, NMR spectra, and X-ray diffraction data. Funding The authors

• /0124/2012 (X-ray Infrastructure), which was cofinanced by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER - 007265).

Efficient synthesis of fluorinated triphenylenes with enhanced arene–perfluoroarene interactions in columnar mesophases

• Yang Chen,
• Jiao He,
• Hang Lin,
• Hai-Feng Wang,
• Ping Hu,
• Bi-Qin Wang,
• Ke-Qing Zhao and
• Bertrand Donnio

Beilstein J. Org. Chem. 2024, 20, 3263–3273, doi:10.3762/bjoc.20.270

• methodologies. The mesomorphous properties of these two sets of compounds were investigated by polarized optical microscopy (POM), differential scanning calorimetry (DSC), and small-and wide-angle X-ray scattering (S/WAXS) and compared to related fluorinated and non-fluorinated homologs. The results showed that

• ) was prepared to grow single crystals suitable for X-ray analysis (Scheme S2 in Supporting Information File 1) in order to confirm the annulation reaction pattern, and 2,3,6,7-tetrakishexyloxy-10-phenyltriphenylene (BTP6, Scheme S3), the non-fluorinated isomer of F6 and PH6 (Figure 1), for probing the

• analysis (Figures S1–S32, Supporting Information File 1), and all the results agree with the proposed molecular structures. Single-crystal structure of F Suitable single crystals of compound F for X-ray analysis were obtained by slow evaporation of an ethyl acetate/ethanol solution (Figure 2, and

Intramolecular C–H arylation of pyridine derivatives with a palladium catalyst for the synthesis of multiply fused heteroaromatic compounds

• Yuki Nakanishi,
• Shoichi Sugita,
• Kentaro Okano and
• Atsunori Mori

Beilstein J. Org. Chem. 2024, 20, 3256–3262, doi:10.3762/bjoc.20.269

• the reaction was carried out with 7a under similar conditions, the cyclization occurred to afford 8a in 81% yield as shown in Scheme 2. The formation of 8a was confirmed by X-ray crystallographic analysis (CCDC 2227450). The related monofunctionalized analog 7b also smoothly underwent cyclization to

• arylation precursors 1a–c. Palladium-catalyzed intramolecular direct arylation for synthesizing 8a and 8b and the X-ray crystallographic structure of 8a. Studies on the reaction conditions for 2a from 1a. Pd-catalyzed C–H arylation of heteroarenes. Supporting Information Accession code CCDC 2227450

• . Supporting Information File 48: Additional experimental details and copies of 1H and 13C{1H} NMR spectra. Acknowledgements We thank Professor Shigeki Mori and Ms. Rimi Konishi (Ehime University) for the X-ray crystallographic analysis.

Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives

• Anastasiya V. Agafonova,
• Mikhail S. Novikov and
• Alexander F. Khlebnikov

Beilstein J. Org. Chem. 2024, 20, 3191–3197, doi:10.3762/bjoc.20.264

• single-crystal X-ray diffraction analysis. The reaction of azetidine with diacyl chloride 2a gave a complex mixture of products, and O-methyl hydroxylamine did not react. Diacyl chloride 2a reacts with methanol and ethanol to give diesters 11a,b (Scheme 5). An experiment with isoxazole 1a and methanol on

• research was carried out using resources of the Centre for Magnetic Resonance, the Research Centre for X-ray Diffraction Studies, the Centre for Chemical Analysis and Materials, and the Computer Centre of the Science Park of St. Petersburg State University. Funding This work was supported by Russian

Synthesis of extended fluorinated tripeptides based on the tetrahydropyridazine scaffold

• Thierry Milcent,
• Pascal Retailleau,
• Benoit Crousse and
• Sandrine Ongeri

Beilstein J. Org. Chem. 2024, 20, 3174–3181, doi:10.3762/bjoc.20.262

• intramolecular Michael addition. Preliminary conformational studies on tripeptides including this scaffold in the central position show an extended conformation in solution (NMR) and in the solid state (X-ray). Keywords: fluoroalkyl groups; heterocycles; hydrazino acids; peptides; tetrahydropyridazines

• LiOH, followed by a coupling reaction with ʟ-valine methyl ester hydrochloride, to give the corresponding four enantiomerically pure tripeptides 8 with satisfactory yields over two steps (Scheme 6). The absolute configuration (S,S,S) of the isomer 8f was unambiguously assigned by X-ray crystallographic

• configuration of compounds 7e and 7e’ and consequently of tripeptides 8e and 8e’ (see Supporting Information File 1). Next, some preliminary conformational studies were performed. Firstly, the X-ray crystallographic analysis of compound 8f did not show any hydrogen-bond pattern and the global structure of the

Controlled oligomerization of [1.1.1]propellane through radical polarity matching: selective synthesis of SF₅- and CF₃SF₄-containing [2]staffanes

• Jón Atiba Buldt,
• Wang-Yeuk Kong,
• Yannick Kraemer,
• Masiel M. Belsuzarri,
• Ansh Hiten Patel,
• James C. Fettinger,
• Dean J. Tantillo and
• Cody Ross Pitts

Beilstein J. Org. Chem. 2024, 20, 3134–3143, doi:10.3762/bjoc.20.259

• truncated after incorporation of two bicyclopentane (BCP) units. Synthetic and computational studies suggest this phenomenon can be attributed to alternating radical polarity matching. In addition, single-crystal X-ray diffraction (SC-XRD) data reveal structurally interesting features of the CF3SF4

• for the first time created an opportunity for structural analysis. We previously reported and contextualized single-crystal X-ray diffraction (SC-XRD) data on 2 [36]; thus, we proceeded to grow crystals of 3 suitable for X-ray analysis through slow evaporation of ethyl acetate. To our surprise, an

• , we confirmed that a phase transition had occurred following structure determination at 240 K [78][79]. The X-ray data revealed that 3 crystallizes in the centrosymmetric orthorhombic space group Pnma in the high temperature phase (HTP) with cell axes a = 21.56 Å, b = 8.95 Å, and c = 7.28 Å, in

Hypervalent iodine-mediated intramolecular alkene halocyclisation

• Charu Bansal,
• Oliver Ruggles,
• Albert C. Rowett and
• Alastair J. J. Lennox

Beilstein J. Org. Chem. 2024, 20, 3113–3133, doi:10.3762/bjoc.20.258

• , deuterium labelling, rearrangements on stereodefined substrates, and structural analyses (NMR and X-ray) of the reaction products. RT-NMR-derived data strongly supported a pathway of alkene activation by the iodane, as opposed to the formation of an N-I(III) adduct. The presence of 5-exo-products, with

• excellent yields. The structures were also assigned by X-ray crystallography. Sulfur nucleophiles In 2015, Li and co-workers reported the synthesis of 5-bromomethyl-2-phenylthiazoline (79, Scheme 41) [48]. Sulfur was used as the internal nucleophile instead of nitrogen, as previously reported by the authors

Cyclodextrin-based rotaxanes for polymer materials: challenge on simultaneous realization of inexpensive production and defined structures

• Yosuke Akae

Beilstein J. Org. Chem. 2024, 20, 3026–3049, doi:10.3762/bjoc.20.252

• formation of this inclusion complex, circular dichroism spectroscopy represents a powerful tool when combined with nuclear magnetic resonance (NMR) and X-ray single-crystal analysis. This is because the induced circular dichroism (ICD) can be observed on the guest molecule of the inclusion complex derived

• the hydrogen bonding by the primary- or secondary-alcohol groups, as confirmed by theoretical analyses. This structure was consistent with a previously reported X-ray crystal structure analysis of the complex structure comprising α-CD, polyion, and Li+ or Cd2+ [45]. Regarding the small rotaxane

• other synthetic methods: (1) the reaction can proceed on a 100 g scale in a 1 L flask and a 500 mL solution of water, sufficiently indicating the possibility of large-scale material applications; (2) the product contains only head-to-head structured [3]rotaxane, as confirmed by the X-ray crystal

4,6-Diaryl-5,5-difluoro-1,3-dioxanes as chiral dopants for liquid crystal compositions

• Maurice Médebielle,
• Peer Kirsch,
• Jérémy Merad,
• Carolina von Essen,
• Clemens Kühn and
• Andreas Ruhl

Beilstein J. Org. Chem. 2024, 20, 2940–2945, doi:10.3762/bjoc.20.246

• enantiomers (R,R)-3/(S,S)-3, (R,R)-4/(S,S)-4 were obtained by slow evaporation from n-heptane solution and structures were determined by X-ray diffraction, which allowed the correlation of the chiroptical properties with the configuration (Figure 2 and Figure 3). The HTP of all enantiomers were measured with

• polar mixture Host 2 it is twice as high as for less polar Host 1. Selected examples of chiral dopants with high HTPs in their nematic host LC mixture. Configuration of (R,R)-3 determined by X-ray crystallography. Configuration of (R,R)-4 determined by X-ray crystallography. Structure–property

Structure and thermal stability of phosphorus-iodonium ylids

• Andrew Greener,
• Stephen P. Argent,
• Coby J. Clarke and
• Miriam L. O’Duill

Beilstein J. Org. Chem. 2024, 20, 2931–2939, doi:10.3762/bjoc.20.245

• functionalities they can transfer. In this study, a fundamental understanding of the thermal stability of phosphorus-iodonium ylids is obtained through X-ray diffraction, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Insights into the structural factors affecting thermal stability

• ][26][27] and the mechanisms by which they decompose when heated through a systematic investigation of structural data from X-ray diffraction (XRD) and thermal stability data from differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The insights from this study will galvanise

• the rational design and synthesis of novel, unstabilised hypervalent iodine(III) compounds and expand the application of these powerful reagents in organic synthesis. Results and Discussion Structural data Twelve phosphorus-iodonium ylids were synthesised (Figure 2). X-ray diffraction data (XRD) of

The charge transport properties of dicyanomethylene-functionalised violanthrone derivatives

• Sondos A. J. Almahmoud,
• Joseph Cameron,
• Dylan Wilkinson,
• Michele Cariello,
• Claire Wilson,
• Alan A. Wiles,
• Peter J. Skabara and
• Graeme Cooke

Beilstein J. Org. Chem. 2024, 20, 2921–2930, doi:10.3762/bjoc.20.244

• single-crystal X-ray analysis were obtained by slow evaporation of a dichloromethane/isopropanol solution of 3b. The crystal structure of 3b, displayed in Figure 4, shows a very similar twisted conformation of the core of the molecule to that of the related methoxy-substituted structure obtained from

• otherwise. The absence of transition states was confirmed by the absence of imaginary frequencies in vibrational frequency calculations. The long side chains were replaced by methyl units to aid the convergence of the geometry optimisations. Crystallography Single crystal X-ray diffraction data for 3b were

Recent advances in transition-metal-free arylation reactions involving hypervalent iodine salts

• Ritu Mamgain,
• Kokila Sakthivel and
• Fateh V. Singh

Beilstein J. Org. Chem. 2024, 20, 2891–2920, doi:10.3762/bjoc.20.243

• aryl groups attached to an iodine atom and an associated "anion". X-ray studies revealed that these iodine(III) compounds typically have a T-type structure 1 (Figure 1). In solution, they dissociate into Ar2I+ and X− counterions 2, with the degree of dissociation influenced by the solvent and the

Synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives via isocyanide-based multicomponent reactions

• Marzieh Norouzi,
• Mohammad Taghi Nazeri,
• Ahmad Shaabani and
• Behrouz Notash

Beilstein J. Org. Chem. 2024, 20, 2870–2882, doi:10.3762/bjoc.20.241

• studied by X-ray diffraction analysis, and the crystal structure is illustrated in Figure 2 (detailed information can be found in the Supporting Information File 1). The 1H NMR spectrum of product 6f obtained through the I-MCR was investigated and some unexpected chemical shifts were observed at room

• analysis, mass spectrum, and IR are consistent with the structure (for details see Supporting Information File 1). Finally, a single crystal X-ray analysis of compound 6a was performed, confirming the structure (Figure 4). The proposed mechanism for an isocyanide-based multicomponent domino reaction for

C–C Coupling in sterically demanding porphyrin environments

• Liam Cribbin,
• Brendan Twamley,
• Nicolae Buga,
• John E. O’ Brien,
• Raphael Bühler,
• Roland A. Fischer and
• Mathias O. Senge

Beilstein J. Org. Chem. 2024, 20, 2784–2798, doi:10.3762/bjoc.20.234

• , borylation of a dodecasubstituted porphyrin’s meso-phenyl position was explored and a subsequent C–C coupling showed the polarity of the reaction can be reversed resulting in higher yields. X-ray analysis of the target compounds revealed the formation of supramolecular assemblies, capable of accommodating

• reactivity, where not previously possible. X-ray crystal structure analysis Despite the many examples in literature of the crystal structure and packing of nonplanar porphyrins [3][6][8][13][52][53], few examples of crystal structure and packing analysis exist for arm-extended porphyrins. One of the few

• porphyrins appended with boronic ester groups to be structurally disseminated by X-ray crystallography [62][63]. Compound 46 was found to crystallize in a 1:1 ratio with bis(pinacolato)diboron, with a void size of 8–9 Å. The formation of channel-type lattice structures is thermodynamically unfavorable, when

Access to optically active tetrafluoroethylenated amines based on [1,3]-proton shift reaction

• Yuta Kabumoto,
• Eiichiro Yoshimoto,
• Bing Xiaohuan,
• Masato Morita,
• Motohiro Yasui,
• Shigeyuki Yamada and
• Tsutomu Konno

Beilstein J. Org. Chem. 2024, 20, 2776–2783, doi:10.3762/bjoc.20.233

• transition state is not stabilized, leading to the increase of the activation energy of the reaction. As a result, the reaction does not proceed smoothly. The absolute configurations of product (S)-23c, (S)-23d, and (S)-23e were determined on the basis of their X-ray crystallographic analyses. The validity

Copper-catalyzed yne-allylic substitutions: concept and recent developments

• Shuang Yang and
• Xinqiang Fang

Beilstein J. Org. Chem. 2024, 20, 2739–2775, doi:10.3762/bjoc.20.232

• stereocenter of the product is controlled by the catalyst. A single crystal of Cu(I) was investigated by X-ray and proved to be the dicopper complex, while the Cu(II) catalyst was revealed as mononuclear copper coordinated with two ligands. Further kinetic isotope experiments and nonlinear relationship studies

• radical-involved mechanism. In addition, a positive nonlinear relationship between the product and ligand indicated that the dinuclear copper is the active catalyst, which was also proved by single crystal X-ray analysis. However, kinetic experiments showed the reaction is first-order on copper, implying

Transition-metal-free decarbonylation–oxidation of 3-arylbenzofuran-2(3H)-ones: access to 2-hydroxybenzophenones

• Bhaskar B. Dhotare,
• Seema V. Kanojia,
• Chahna K. Sakhiya,
• Amey Wadawale and
• Dibakar Goswami

Beilstein J. Org. Chem. 2024, 20, 2655–2667, doi:10.3762/bjoc.20.223

• over anhydrous Na2SO4. FTIR spectra were recorded as films with a Bruker Tensor II spectrophotometer. The 1H and 13C NMR spectra were recorded with a Varian 500 MHz NMR spectrometer, and were processed using Bruker TOPSPIN software. Melting points (mp) were measured on a Büchi B-540 apparatus. X-ray

• data were collected either on an Agilent Supernova system equipped with a microfocus Cu source (λ = 1.54184 Å) and a titan CCD detector, or on a XtaLAB Synergy, Dualflex, HyPix four-circle diffractometer with a micro-focus sealed X-ray tube using a mirror as monochromator and a HyPix detector. The

• -crystal XRD The data were collected using a similar method as reported by us earlier [23], using a XtaLAB Synergy, Dualflex, HyPix four-circle diffractometer, a micro-focus sealed X-ray tube and a HyPix detector. The data were corrected using SCALE3 ABSPACK and the structure were solved using SHELXT

Applications of microscopy and small angle scattering techniques for the characterisation of supramolecular gels

• Connor R. M. MacDonald and
• Emily R. Draper

Beilstein J. Org. Chem. 2024, 20, 2608–2634, doi:10.3762/bjoc.20.220

• increases, and techniques develop at a rapid pace [10][11][52][53]. SAS techniques include small angle X-ray scattering (SAXS), small angle neutron scattering (SANS), and their wide angle (WAXS) and ultra-small angle (USAXS and USANS, respectively) analogues have various advantages and drawbacks compared to

• solvents [60]. This is so that the solvent can be suitably removed from the scattering pattern and a model then be used to fit only the material of interest. For X-ray scattering, most solvents have a suitable difference in SLD and so can be used, but should be checked. However, in neutron scattering the

• , cells that allow for the coupling of SAS with non-X-ray techniques continue to be developed; these include spectroscopy, rheology, and electrochemistry [62][63][64]. Ascribing changes in properties of interest directly to changes in the structure further elucidates the interesting properties of self

Base-promoted cascade recyclization of allomaltol derivatives containing an amide fragment into substituted 3-(1-hydroxyethylidene)tetronic acids

• Andrey N. Komogortsev,
• Constantine V. Milyutin and
• Boris V. Lichitsky

Beilstein J. Org. Chem. 2024, 20, 2585–2591, doi:10.3762/bjoc.20.217

• purification. The synthetic utility of the prepared tetronic acids was demonstrated by further transformations at the hydroxyethylidene fragment. The structures of one obtained tetronic acid and one product of derivatization were confirmed by X-ray analysis. Keywords: allomaltol; base-promoted recyclization

• fragment in the region δ = 2.5–2.4 ppm and methylene unit at δ = 2.7–2.5 ppm. The remaining signals are also in good agreement with the presented structure. Besides that, compound 4 has been analyzed using X-ray diffraction (Figure 1). It is important to emphasize that based on X-ray data the structure of

• refluxing EtOH allowed us to obtain substituted enehydrazine 7 (Scheme 5a). The similar condensation with amine 8 led to enamine derivative 9 (Scheme 5b). Based on the data of X-ray analysis compound 7 has the same configuration of double and hydrogen bonds as in the case of starting tetronic acids 4

Anion-dependent ion-pairing assemblies of triazatriangulenium cation that interferes with stacking structures

• Yohei Haketa,
• Takuma Matsuda and
• Hiromitsu Maeda

Beilstein J. Org. Chem. 2024, 20, 2567–2576, doi:10.3762/bjoc.20.215

• synthesized to investigate the interactions for the bulky cation. Single-crystal X-ray analysis of the TATA+ ion pairs revealed solid-state ion-pairing assemblies without stacking at the cationic π-planes. The TATA+ cation showed counteranion-dependent assembly structures, with smaller counteranions located

• at the top of TATA+ and bulkier counteranions displaced from the TATA+ plane to interact with the surrounding TATA+. Keywords: charged π-electronic systems; ion pairs; single-crystal X-ray analysis; solid-state assemblies; triazatriangulenium cation; Introduction Triangulenium cations [1][2] have

• orthogonal arrangement in comparison with the phenyl moieties in 1b+. Solid-state ion-pairing assemblies of the ion pairs 2+-X− (X− = Cl−, BF4−, PF6−, B(C6F5)4−, and PCCp−) were investigated by X-ray analysis of the orange rod-shaped single crystals, which were obtained by vapour diffusion using CHCl3/n

HFIP as a versatile solvent in resorcin[n]arene synthesis

• Hormoz Khosravi,
• Valeria Stevens and
• Raúl Hernández Sánchez

Beilstein J. Org. Chem. 2024, 20, 2469–2475, doi:10.3762/bjoc.20.211

• compounds. Acknowledgements This research was supported through instrumentation made available through the Shared Instrumentation Authority at Rice University. We thank Dr. Christopher L. Pennington for assistance with HRMS data collection and Dr. Hong-Lei Xu for help with single-crystal X-ray diffraction