Recent advances in carbocupration of α-heterosubstituted alkynes

• Ahmad Basheer and
• Ilan Marek

Beilstein J. Org. Chem. 2010, 6, No. 77, doi:10.3762/bjoc.6.77

• for useful synthetic transformations, it would be important to prepare selectively the α-isomer 8b as well (Scheme 4) [18]. As carbocupration of 7 leads to either variable amounts of the α- and β-isomers (Scheme 4) or mainly to the β-isomer (Scheme 5), the exclusive formation of the α-isomer could

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

• David M. Hodgson and
• Leonard H. Winning

Beilstein J. Org. Chem. 2008, 4, No. 38, doi:10.3762/bjoc.4.38

• established a stereoselective route to 3-exo-substituted 2-azabenzonorbornenes, further synthetic transformations of these adducts were addressed. Firstly, we considered that the 2-azabenzonorbornene framework could be a masked pyrrolidine: cleavage of the aromatic ring would reveal a stereodefined 2,4

Allylsilanes in the synthesis of three to seven membered rings: the silylcuprate strategy

• Asunción Barbero,
• Francisco J. Pulido and
• M. Carmen Sañudo

Beilstein J. Org. Chem. 2007, 3, No. 16, doi:10.1186/1860-5397-3-16

• particular allylsilanes have attracted considerable attention due to the increasing number of new methodologies that allow useful synthetic transformations. [1][2] Over the last decade allenes have emerged as one of the best sources for the synthesis of allylsilanes. [3] Although unactivated allenes do not

EcoScale, a semi- quantitative tool to select an organic preparation based on economical and ecological parameters

• Koen Van Aken,
• Lucjan Strekowski and
• Luc Patiny

Beilstein J. Org. Chem. 2006, 2, No. 3, doi:10.1186/1860-5397-2-3

• . Examples of calculations The EcoScale evaluations of four important synthetic transformations taken from the recent literature are shown below. Workup involves manipulations in the given order. The sum of all penalty points is 36 (Table 2), which gives total score of 64 on the EcoScale (an acceptable