A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

• Nimalini D. Moirangthem and
• Warjeet S. Laitonjam

Beilstein J. Org. Chem. 2010, 6, 1056–1060, doi:10.3762/bjoc.6.120

• common synthetic route involves the amidation of 2-aminobenzoic acid or its derivatives, i.e., 2-aminobenzonitrile, 2-aminobenzoates, and 2-arylnitrilium salts, followed by oxidative ring closure [10][11][12][13]. Other synthetic pathways include the cyclization of anthranilamides with aldehydes [14

N-acylation of ethanolamine using lipase: a chemoselective catalyst

• Mazaahir Kidwai,
• Roona Poddar and
• Poonam Mothsra

Beilstein J. Org. Chem. 2009, 5, No. 10, doi:10.3762/bjoc.5.10

• (triacyl glycerol hydrolases EC 3.1.1.3) catalyze hydrolysis, esterification, transesterification, thioesterification, amidation, epoxidation etc. [5][6][7][8][9][10]. The use of immobilized lipases is on the rise, as these work well with non-aqueous media [11]. Apart from the convenient handling, these