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Search for "HSBM" in Full Text gives 8 result(s) in Beilstein Journal of Organic Chemistry.
Menadione: a platform and a target to valuable compounds synthesis
Beilstein J. Org. Chem. 2022, 18, 381–419, doi:10.3762/bjoc.18.43
Liquid-assisted grinding and ion pairing regulates percentage conversion and diastereoselectivity of the Wittig reaction under mechanochemical conditions
Beilstein J. Org. Chem. 2018, 14, 688–696, doi:10.3762/bjoc.14.57
- the Wittig reaction. Keywords: green chemistry; high-speed ball milling; HSBM; LAG; liquid-assisted grinding; Wittig; Introduction Mechanochemistry is maturing as a discipline and continuing to develop and grow [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Thus it is important to continue
Correction: Mechanochemical enzymatic resolution of N-benzylated-β3-amino esters
Beilstein J. Org. Chem. 2017, 13, 2128–2130, doi:10.3762/bjoc.13.210
- under ball milling. Substrate scope for the enzymatic resolution of N-benzylated-β3-amino esters. Recycling capacity of immobilized CALB under HSBM conditions. Scaling-up of the enzymatic hydrolysis reaction under ball-milling using substrate rac-1a. Supporting Information Supporting Information File
Mechanochemical synthesis of small organic molecules
Beilstein J. Org. Chem. 2017, 13, 1907–1931, doi:10.3762/bjoc.13.186
- ]. Traditional solution-based C–O bond synthesis generally needs large amount of solvents, excess chlorinating agent, harsh reaction conditions, a tedious isolation process, etc. compared to solvent-less grinding or mechanomilling [89]. In 2011, Mack and co-workers applied the high-speed ball milling (HSBM
Mechanochemical enzymatic resolution of N-benzylated-β3-amino esters
Beilstein J. Org. Chem. 2017, 13, 1728–1734, doi:10.3762/bjoc.13.167
- CALB enzyme under high-speed ball-milling (HSBM) conditions as a method to obtain enantiopure N-benzylated-β3-amino acids (Scheme 1). Results and Discussion A racemic mixture of substrate rac-1a (82 mg, 1 equiv) was milled in an Agate jar (12 mm of diameter, 4.6 mL) with an Agate ball (6 mm of diameter
- enantioenriched (R)-N-benzylated-β3-amino acid (R)-2a was observed, recovering 51% of enantioenriched starting material. It could be established by chiral HPLC that the ee of the product amounted 80% (Table 1, entry 1). This assay demonstrated that enzymatic hydrolysis can indeed be carried out under HSBM
- could be established that the CALB enzyme and N-benzylated-β3-amino esters are stable to the mechanical force caused by HSBM. We then focused our attention on the search of the best conditions for this enzymatic mechanochemical resolution. First of all, we examined the effect of the milling frequency
Encaging palladium(0) in layered double hydroxide: A sustainable catalyst for solvent-free and ligand-free Heck reaction in a ball mill
Beilstein J. Org. Chem. 2017, 13, 1661–1668, doi:10.3762/bjoc.13.160
- milling (HSBM) conditions at room temperature. The effects of milling-ball size, milling-ball filling degree, reaction time, rotation speed and grinding auxiliary category, which would influence the yields of mechanochemical Heck reactions, were investigated in detail. The characterization results of XRD
- , ICP–MS and XPS suggest that Pd/MgAl-LDHs have excellent textural properties with zero-valence Pd on its layers. The reaction results indicate that the catalyst could be utilized in HSBM systems to afford a wide range of Heck coupling products in satisfactory yields. Furthermore, this catalyst could be
- easily recovered and reused for at least five times without significant loss of catalytic activity. Keywords: ball milling; Heck reaction; layer double hydroxides; solvent-free; supported Pd catalyst; Introduction High-speed ball milling (HSBM)-assisted transition metal-catalyzed cross-coupling reactions
Enabling technologies and green processes in cyclodextrin chemistry
Beilstein J. Org. Chem. 2016, 12, 278–294, doi:10.3762/bjoc.12.30
- -speed ball mills (HSBM), operate in vibrating, mixer or planetary mode. A very simple vibrating BM, consisting of a small milling cup with one or two balls, has been used for a long time in traditional IR spectrometry to homogenize the sample and KBr. Mixer BM are slightly different from the vibrating
- planetary or vibratory ball mills and HEBM is a common synonym for HSBM [81]. The lower particle size in grinding produces microdeformation in the ground material crystal lattice, while energy is partially spent in creating microstresses, which eventually slow powder grinding. An efficient wet grinding
- transition state [87]. Solvent effects and ion pair formation are critical to the mechanism of SN1 reactions meaning that this mechanism is usually restricted in HSBM reactions. While solid-state intermolecular SN2 reactions depend on contact between interacting particles only, SN1 reactions may show more
Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach
Beilstein J. Org. Chem. 2012, 8, 2132–2141, doi:10.3762/bjoc.8.240
- cyclohexanone, cyclopentanone and acetone with various aromatic aldehydes 2 under solvent-free reaction conditions with the high-speed ball-milling (HSBM) technique (Scheme 4) [35]. Using 7 mol % of III the anti-aldol products (in the case of cyclohexanone) and syn-aldol product (in the case of cyclopentanone
- ) were obtained in good to high yield (62–94%), moderate to high diastereoselectivity (31:69 to 91:9 dr, anti/syn) and moderate to high enantioselectivity (55–95% ee). Under HSBM conditions, III also catalyses the aldol reaction of acetone with 2a to provide the corresponding aldol product in 82% yield
- )-tryptophan (IV) was shown to be an efficient organocatalyst for asymmetric aldol reactions of ketones with aromatic aldehydes in the presence of water by using HSBM (Scheme 4) [37]. The corresponding aldol products 3 were obtained in good yield (64–90%), low to high diastereoselectivity (40:60 to 98:2 dr
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