Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach

• Dileep Kumar Singh and
• Rajesh Kumar

Beilstein J. Org. Chem. 2023, 19, 928–955, doi:10.3762/bjoc.19.71

• . MgI2 etherate-catalyzed synthesis and proposed mechanism of N-arylpyrrole derivatives 21. Nicotinamide catalyzed synthesis of pyrroles 23. ZrOCl2∙8H2O catalyzed synthesis and proposed mechanism of pyrrole derivatives 25. AcONa catalyzed synthesis of N-substituted pyrroles 27. Squaric acid-catalyzed

Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolecular [1,5]-hydride shift/isomerization reaction

• Chun-Huan Jiang,
• Xiantao Lei,
• Le Zhen,
• Hong-Jin Du,
• Xiaoan Wen,
• Qing-Long Xu and
• Hongbin Sun

Beilstein J. Org. Chem. 2014, 10, 2892–2896, doi:10.3762/bjoc.10.306

• Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolcular [1,5]-hydride shift/isomerization reaction has been realized, using the inherent reducing power of 3-pyrrolines. A series of N-arylpyrrole containing amines are obtained in high yields. Keywords

• ][20][21][22][23][24][25][26][27][28][29][30]. On the other hand, compounds containing the N-arylpyrrole moiety serve as important building blocks for the synthesis of various complex molecules and exhibit a larger number of biological effects [31][32][33]. In 2009, Tunge's group disclosed that N

• Scheme 2. The reactions proceeded smoothly to give the corresponding N-arylpyrrole amines 3 in good to excellent yields (71–97% yields). Notably, the substitution of the benzene ring had little effect on the reaction since both electron-donating (3b, 3c) and electron-withdrawing groups (3d–i) were

An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles

• Alexandre Jean,
• Jérôme Blanchet,
• Jacques Rouden,
• Jacques Maddaluno and
• Michaël De Paolis

Beilstein J. Org. Chem. 2013, 9, 1480–1486, doi:10.3762/bjoc.9.168

• regioselective oxidation of these substrates is demonstrated, extending the molecular diversity and versatility of these scaffolds. Keywords: C–H oxidation; isomerization; N-arylpyrrole; organocatalysis; Introduction Due to their presence in some natural products [1] and pharmaceuticals [2][3][4], the