Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma

• Chen Zhang,
• Kah Yean Lum,
• Jonathan M. White,
• Paul I. Forster,
• Nicholas Booth,
• Sunita A. Ramesh and
• Rohan A. Davis

Beilstein J. Org. Chem. 2026, 22, 691–704, doi:10.3762/bjoc.22.54

• )pinoresinol had slight cytotoxicity at 10 µM. A transwell anti-invasive assay on the same compound showed a reduction in the invasion of adult U251MG cells by 50% and pediatric KNS42 cells by 30%, with IC50 values of 0.26 and 0.40 µM, respectively. Keywords: anti-invasive; cytotoxicity; Eremophila maculata

• cells represent a powerful approach that can augment current therapies, prevent metastasis, and improve patient quality of life and survival. Cytotoxicity is defined as the ability of a compound to cause cell death, while anti‑invasive properties refer to the ability of compounds to slow down or block

• cancer cells from moving. In this study, a unique plant-derived lignan‑based library was screened against glioblastoma (brain cancer) cell lines to evaluate anti-invasive and cytotoxicity effects. Results and Discussion The air-dried and ground seeds of E. maculata were sequentially extracted with CH2Cl2

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids

• Eszter Lajkó,
• Sarah Spring,
• Rózsa Hegedüs,
• Beáta Biri-Kovács,
• Sven Ingebrandt,
• Gábor Mező and
• László Kőhidai

Beilstein J. Org. Chem. 2018, 14, 2495–2509, doi:10.3762/bjoc.14.226

• anticancer drug resistance as they are co-administrated with other chemotherapeutics [29][30]. Nevertheless, there is some controversy about the effects of short-chain fatty acids on the metastatic ability of melanoma cells, since both pro-invasive [31] and anti-invasive [29][32] activities have been