/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

Search results

Search for "antifungal activity" in Full Text gives 52 result(s) in Beilstein Journal of Organic Chemistry.

PAGE

PAGE
First
Previous
1
2
3
Next
Last

Approaches towards the synthesis of 5-aminopyrazoles

Ranjana Aggarwal,
Vinod Kumar,
Rajiv Kumar and
Shiv P. Singh

Beilstein J. Org. Chem. 2011, 7, 179–197, doi:10.3762/bjoc.7.25

mammalian receptors [10]. The simple N-phenyl amide of 5-amino -1,3-dimethylpyrazole-4-carboxylic acid V has been shown to exhibit antifungal activity [11] (Figure 1). The 5-amino-1-pyrazinyl-3-carboxamidopyrazole derivative VI has been recently reported as a potent antibacterial agent with a very broad

PDF

Graphical Abstract

Figure 1: Pharmacologically active 5-aminopyrazoles.

Jump to Figure 1

Scheme 1: General equation for the condensation of β-ketonitriles with hydrazines.

Jump to Scheme 1

Scheme 2: Reaction of hydrazinoheterocycles with α-phenyl-β-cyanoketones (4).

Jump to Scheme 2

Scheme 3: Condensation of cyanoacetaldehyde (7) with hydrazines.

Jump to Scheme 3

Scheme 4: Synthesis of 5-aminopyrazoles and their sulfonamide derivatives.

Jump to Scheme 4

Scheme 5: Synthesis of 5-aminopyrazoles, containing a cyclohexylmethyl- or phenylmethyl- sulfonamido group at...

Jump to Scheme 5

Scheme 6: Regioselective synthesis of 3-amino-2-alkyl (or aryl) thieno[3,4-c]pyrazoles 19.

Jump to Scheme 6

Scheme 7: Solid supported synthesis of 5-aminopyrazoles.

Jump to Scheme 7

Scheme 8: Synthesis of 5-aminopyrazoles from resin supported enamine nitrile 25 as the starting material.

Jump to Scheme 8

Scheme 9: Two-step “catch and release” solid-phase synthesis of 3,4,5-trisubstituted pyrazoles.

Jump to Scheme 9

Scheme 10: Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.

Jump to Scheme 10

Scheme 11: Synthesis of the 5,5-ring system, imidazo[1,2-b]pyrazol-2-ones.

Jump to Scheme 11

Scheme 12: Synthesis of 5-amino-3-(pyrrol-2-yl)pyrazole-4-carbonitrile.

Jump to Scheme 12

Scheme 13: Synthesis of N-(1,3-diaryl-1H-pyrazol-5-yl)benzamide.

Jump to Scheme 13

Scheme 14: Synthesis of 3,7-bis(arylazo)-6-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazoles.

Jump to Scheme 14

Scheme 15: Synthesis of 3,5-diaminopyrazole.

Jump to Scheme 15

Scheme 16: Synthesis of 5-amino-4-cyanopyrazole and 5-amino-3-hydrazinopyrazole.

Jump to Scheme 16

Scheme 17: Synthesis of 3,5-diaminopyrazoles with substituted malononitriles.

Jump to Scheme 17

Scheme 18: Synthesis of 3,5-diamino-4-oximinopyrazole.

Jump to Scheme 18

Scheme 19: Synthesis of 4-arylazo-3,5-diaminopyrazoles.

Jump to Scheme 19

Scheme 20: Synthesis of 3- or 5-amino-4-cyanopyrazoles.

Jump to Scheme 20

Scheme 21: Synthesis of triazenopyrazoles.

Jump to Scheme 21

Scheme 22: Synthesis of 5(3)-aminopyrazoles.

Jump to Scheme 22

Scheme 23: Synthesis of 3-substituted 5-amino-4-cyanopyrazoles.

Jump to Scheme 23

Scheme 24: Synthesis of 2-{[(1-acetyl-4-cyano-1H-pyrazol-5-yl)amino]methylene}malononitrile.

Jump to Scheme 24

Scheme 25: Synthesis of 5-aminopyrazole carbodithioates and 5-amino-3-arylamino-1-phenylpyrazole-4-carboxamide...

Jump to Scheme 25

Scheme 26: Synthesis of 5-amino-4-cyanopyrazoles.

Jump to Scheme 26

Scheme 27: Synthesis of thiazolylpyrazoles.

Jump to Scheme 27

Scheme 28: Synthesis of 5-amino-1-heteroaryl-3-methyl/aryl-4-cyanopyrazoles.

Jump to Scheme 28

Scheme 29: Synthesis of 5-amino-3-methylpyrazole-4-carboxamide.

Jump to Scheme 29

Scheme 30: Synthesis of 4-acylamino-3(5)-amino-5(3)-arylsulfanylpyrazoles.

Jump to Scheme 30

Scheme 31: Synthesis of 5-amino-1-aryl-4-diethoxyphosphoryl-3-halomethylpyrazoles.

Jump to Scheme 31

Scheme 32: Synthesis of substituted 5-amino-3-trifluoromethylpyrazoles 114 and 118.

Jump to Scheme 32

Scheme 33: Solid-support synthesis of 5-N-alkylamino and 5-N-arylaminopyrazoles.

Jump to Scheme 33

Scheme 34: Synthesis of 5-amino-1-cyanoacetyl-3-phenyl-1H-pyrazole.

Jump to Scheme 34

Scheme 35: Synthesis of 3-substituted 5-amino-1-aryl-4-(benzothiazol-2-yl)pyrazoles.

Jump to Scheme 35

Scheme 36: Synthesis of 5-amino-4-carbethoxy-3-methyl-1-(4-sulfamoylphenyl)pyrazole.

Jump to Scheme 36

Scheme 37: Synthesis of inhibitors of hsp27-phosphorylation and TNFa-release.

Jump to Scheme 37

Scheme 38: Synthesis of the diglycylpyrazole 142.

Jump to Scheme 38

Scheme 39: Synthesis of 5-amino-1-aryl-4-benzoylpyrazole derivatives.

Jump to Scheme 39

Scheme 40: Synthesis of 4-benzoyl-3,5-diamino-1-(2-cyanoethyl)pyrazole.

Jump to Scheme 40

Scheme 41: Synthesis of the 5-aminopyrazole derivative 150.

Jump to Scheme 41

Scheme 42: Synthesis of 3,5-diaminopyrazoles 153.

Jump to Scheme 42

Scheme 43: Synthesis of 5-aminopyrazoles derivatives 155 via lithiated intermediates.

Jump to Scheme 43

Scheme 44: Synthesis of 5-amino-4-(1,2,4-oxadiazol-5-yl)-pyrazoles 157.

Jump to Scheme 44

Scheme 45: Synthesis of a 5-aminopyrazole with anticonvulsant activity.

Jump to Scheme 45

Scheme 46: Synthesis of tetrasubstituted 5-aminopyrazole derivatives.

Jump to Scheme 46

Scheme 47: Synthesis of substituted 5-aminopyrazoles from hydrazonoyl halides.

Jump to Scheme 47

Scheme 48: Synthesis of 3-amino-5-phenylpyrazoles from isothiazoles.

Jump to Scheme 48

Scheme 49: Synthesis of 5-aminopyrazoles via ring transformation.

Jump to Scheme 49

Album

Review

Published 09 Feb 2011

Full text

Synthesis of some novel hydrazono acyclic nucleoside analogues

Mohammad N. Soltani Rad,
Ali Khalafi-Nezhad and
Somayeh Behrouz

Beilstein J. Org. Chem. 2010, 6, No. 49, doi:10.3762/bjoc.6.49

been an increase in the number of antifungal drugs available with various structures and scaffolds. However, their clinical value has been limited by the emergence of drug resistance, high risk of toxicity, insufficiencies in their antifungal activity as well as undesirable side effects. This situation

PDF