New reactive intermediates in organic chemistry

• Götz Bucher

Beilstein J. Org. Chem. 2013, 9, 613–614, doi:10.3762/bjoc.9.67

• have their place. This Thematic Series of the Beilstein Journal of Organic Chemistry is meant to highlight recent developments in the chemistry of reactive intermediates, and to illustrate the current state of the art in a number of very varied research fields. Götz Bucher Glasgow, March 2013

Carbometallation chemistry

• Ilan Marek

Beilstein J. Org. Chem. 2013, 9, 234–235, doi:10.3762/bjoc.9.27

• substituted nonactivated alkenes. I would like to warmly thank all the contributors of this Thematic Series that have beautifully highlighted the state of the art of the field. I have tremendously enjoyed reading this Thematic Series and I am convinced that you will all share in this pleasure! Ilan Marek

Organocatalytic C–H activation reactions

• Subhas Chandra Pan

Beilstein J. Org. Chem. 2012, 8, 1374–1384, doi:10.3762/bjoc.8.159

• being one of the “key green chemistry research areas” [4][5][6]. This review describes the current “state of the art” in organocatalyzed C–H activation reactions and highlights recent advances in sp2 and sp3 C–H bond functionalization. For simplicity, iodide or hypervalent iodine-mediated metal-free C–H

Organocatalysis

• Benjamin List

Beilstein J. Org. Chem. 2012, 8, 1358–1359, doi:10.3762/bjoc.8.156

• Benjamin List Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany 10.3762/bjoc.8.156 Keywords: organocatalysis; During the past 12 years or so, hardly any other field has impacted the art and science of chemical synthesis more profoundly than

• has plentiful and complementary reactivity to offer. Indeed, certain things that cannot be done with enzymes or metals may well be feasible with organic catalysts. The present Thematic Series serves to showcase the current state of the art of organocatalysis and covers many of the aspects mentioned

Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system

• Caterina Fraschetti,
• Matthias C. Letzel,
• Antonello Filippi,
• Maurizio Speranza and
• Jochen Mattay

Beilstein J. Org. Chem. 2012, 8, 539–550, doi:10.3762/bjoc.8.62

• , 35501 Bielefeld, Germany 10.3762/bjoc.8.62 Abstract This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement

Syntheses and applications of furanyl-functionalised 2,2’:6’,2’’-terpyridines

• Jérôme Husson and
• Michael Knorr

Beilstein J. Org. Chem. 2012, 8, 379–389, doi:10.3762/bjoc.8.41

• describes the state of the art concerning preparation and applications of such terpyridines bearing a furanyl ring. Review Synthesis by ring closure of 1,5-diketones In 1976, Kröhnke introduced a synthetic methodology to prepare pyridine derivatives that relies on the ring closure of 1,5-diketo-derivatives

Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4-bromophenol, a key intermediate of adapalene

• Nan Wang,
• Ronghua Wang,
• Xia Shi and
• Gang Zou

Beilstein J. Org. Chem. 2012, 8, 227–233, doi:10.3762/bjoc.8.23

• with higher selectivities. However, the work-up procedure of mineral-acid-promoted reactions necessitates aqueous quenching and neutralization steps to remove the acids, resulting in enormous quantities of waste. For example, although the state-of-the-art process promoted by combination of concentrated

Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• Ruslan Yuryev Simon Strompen Andreas Liese Institute of Technical Biocatalysis, Hamburg University of Technology, Denickestr. 15, 21073, Hamburg, Germany 10.3762/bjoc.7.169 Abstract This review highlights the state of the art in the field of coupled chemo(enzymatic) reactions in continuous flow

Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current

• Alicja Schlange,
• Antonio Rodolfo dos Santos,
• Ulrich Kunz and
• Thomas Turek

Beilstein J. Org. Chem. 2011, 7, 1412–1420, doi:10.3762/bjoc.7.165

• preparation in a flow reactor which could be used at a large scale. Keywords: carbon nanotubes; continuous catalyst synthesis; direct electrical heating; flow reactors; fuel cell platinum catalyst; Introduction Batch processes represent the state of the art in catalyst preparation. One reason for employing

Chemistry in flow systems II

• Andreas Kirschning

Beilstein J. Org. Chem. 2011, 7, 1046–1047, doi:10.3762/bjoc.7.119

• the scope of this enabling technology with far reaching implications even for industrial biotechnology. I am thankful to all my colleagues who have helped to create this diverse and state of the art flow series. Finally, special thanks are dedicated to the staff of the Beilstein-Institut for their

Functionalization of anthracene: A selective route to brominated 1,4-anthraquinones

• Kiymet Berkil Akar,
• Osman Cakmak,
• Orhan Büyükgüngör and
• Ertan Sahin

Beilstein J. Org. Chem. 2011, 7, 1036–1045, doi:10.3762/bjoc.7.118

• Kiymet Berkil Akar Osman Cakmak Orhan Buyukgungor Ertan Sahin Department of Chemistry, Faculty of Art and Science, Gaziosmanpasa University, 60250, Tokat, Turkey Department of Physics, Faculty of Art and Science, Ondokuzmayıs University, 55060, Samsun, Turkey Department of Chemistry, Faculty of

• Art and Science, Atatürk University, 25240, Erzurum, Turkey 10.3762/bjoc.7.118 Abstract Efficient and stereoselective syntheses are described for the preparation of 2,3,9,10-tetrabromo-1,4-dimethoxy-1,2,3,4-tetrahydroanthracenes 7, 8 and the corresponding 1,4-diol 17 by silver ion-assisted solvolysis

Stereoselectivity of supported alkene metathesis catalysts: a goal and a tool to characterize active sites

• Christophe Copéret

Beilstein J. Org. Chem. 2011, 7, 13–21, doi:10.3762/bjoc.7.3

• tool to characterize active sites of heterogeneous catalysts and finally to propose strategies to improve catalysts based on the current state of the art. Keywords: active sites; metathesis; stereoselectivity; supported catalysts; Introduction Achieving high selectivity and, in particular

• (styrenyl systems or alkenes with electron withdrawing substituents) [19][20][21]. Here the discussion will focus on the stereoselectivity of alkene metathesis in order to delineate the current state of the art in the case of heterogeneous catalysts and show how it can be used to characterize active sites

Progress in metathesis chemistry

• Karol Grela

Beilstein J. Org. Chem. 2010, 6, 1089–1090, doi:10.3762/bjoc.6.124

• appreciated and more and more commercial applications will surely follow. The papers collected in this Thematic Series nicely highlight many of the aspects mentioned above and will certainly help to update the “state of the art” knowledge in this fascinating field. In this Thematic Series contributions from

Chiral gels derived from secondary ammonium salts of (1R,3S)-(+)-camphoric acid

• Tapas Kumar Adalder,
• N. N. Adarsh,
• Ravish Sankolli and
• Parthasarathi Dastidar

Beilstein J. Org. Chem. 2010, 6, 848–858, doi:10.3762/bjoc.6.100

• continuous expanding area on account of their various promising applications [11][12][13]. Broadly, LMOGs are used in cosmetics [14], tissue engineering [15], drug delivery and biomedical applications [16][17][18][19], art conservation [20][21][22], templated synthesis of nanoparticles [23][24], capture and

Organic gelators and hydrogelators

• Jean-Pierre Desvergne

Beilstein J. Org. Chem. 2010, 6, 846–847, doi:10.3762/bjoc.6.99

• nanoobject conception. Thus, owing to their non-conventional behaviour, low molecular weight gelators are very attractive for applications in various areas, including supramolecular templates or matrices, transport and release of drugs, art conservation, cosmetics, sensors, optoelectronics, actuators, etc

Functionalized polymers: synthesis and properties

• Helmut Ritter

Beilstein J. Org. Chem. 2010, 6, No. 55, doi:10.3762/bjoc.6.55

• functionalized polymers to update the “state of the art” of knowledge in this field. It is therefore a great pleasure to serve as an editor for this series of articles. Helmut Ritter Düsseldorf, May 2010

Flow through reactors for organic chemistry: directly electrically heated tubular mini reactors as an enabling technology for organic synthesis

• Ulrich Kunz and
• Thomas Turek

Beilstein J. Org. Chem. 2009, 5, No. 70, doi:10.3762/bjoc.5.70

• temperature profile at high conversion will be no longer linear. But this is not a big disadvantage, because it is well known to those skilled in the art that kinetic measurements can be done easily at low conversion. In such a case the reactor is operated in a differential mode to measure reaction rates at

Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• total syntheses have been achieved [15][16][17][18][19][20]. Also, this review will summarize the current state of the art concerning the chemistry and biology of mitomycins. It will show and comment on the methodologies that have been successfully employed in total syntheses as well as approaches

Highly brominated anthracenes as precursors for the convenient synthesis of 2,9,10-trisubstituted anthracene derivatives

• Osman Cakmak,
• Leyla Aydogan,
• Kiymet Berkil,
• Ilhami Gulcin and
• Orhan Buyukgungor

Beilstein J. Org. Chem. 2008, 4, No. 50, doi:10.3762/bjoc.4.50

• Osman Cakmak Leyla Aydogan Kiymet Berkil Ilhami Gulcin Orhan Buyukgungor Gaziosmanpasa University, Faculty of Art and Science, Department of Chemistry, TR-60240, Tokat, Turkey Ataturk University, Faculty of Art and Science, Department of Chemistry, TR-25240, Erzurum, Turkey Ondokuzmayis University

• , Faculty of Art and Science, Department of Physics, TR-55060, Samsun, Turkey (author to whom inquries concerning the X-ray structure should be directed) 10.3762/bjoc.4.50 Abstract When 9,10-dibromoanthracene was treated with bromine in CCl4 without a catalyst, 1,2,3,4,9,10-hexabromo-1,2,3,4