Mechanical stability of bivalent transition metal complexes analyzed by single-molecule force spectroscopy

• Manuel Gensler,
• Christian Eidamshaus,
• Maurice Taszarek,
• Hans-Ulrich Reissig and
• Jürgen P. Rabe

Beilstein J. Org. Chem. 2015, 11, 817–827, doi:10.3762/bjoc.11.91

• as self-regulative mechanism. This protein is activated by hydrodynamic forces occurring in injured blood vessels to promote hemostasis [11]. Mechanical stabilities are also of growing interest for the design of biomaterials mimicking the muscle protein titin [12][13] and smart polymers including

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

• Qiang Wei,
• Theresa L. M. Pohl,
• Anja Seckinger,
• Joachim P. Spatz and
• Elisabetta A. Cavalcanti-Adam

Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87

• factors to induce osteogenic differentiation of stem cells, and discuss the signaling pathways that are initiated by both individual and cooperative parameters. The joint effect of integrin ligands and growth factors is highlighted as the multivalent interactions for bone therapy. Keywords: biomaterials

• synthetic integrin ligands were developed to control the interaction between biomaterials and stem cells. The effect of the topography and the distribution of the ligands on cell adhesion, proliferation, and differentiation were intensively studied as well [7]. Besides integrin ligands, growth factors

• together for developing new biomaterials to enhance bone regeneration. For example, the microspheres with immobilized RGD peptide and adsorbed BMP-2 exhibits high potential for cell adhesion and differentiation of MSCs [86]. In another case, the pro-osteogenic α2β1 integrin-specific GFOGER peptide ligands

Synthesis and characterization of pH responsive D-glucosamine based molecular gelators

• Navneet Goyal,
• Hari P. R. Mangunuru,
• Bargav Parikh,
• Sonu Shrestha and
• Guijun Wang

Beilstein J. Org. Chem. 2014, 10, 3111–3121, doi:10.3762/bjoc.10.328

• for soft biomaterials. Low molecular weight hydrogelators are especially useful for exploring biomedical applications. Previously, we found that 4,6-O-benzylidene acetal protected D-glucose and D-glucosamine are well-suited as building blocks for the construction of low molecular weight gelators. To

Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application

• Juliana P. L. Gonçalves,
• Afnan Q. Shaikh,
• Manuela Reitzig,
• Daria A. Kovalenko,
• Jan Michael,
• René Beutner,
• Gianaurelio Cuniberti,
• Dieter Scharnweber and
• Jörg Opitz

Beilstein J. Org. Chem. 2014, 10, 2765–2773, doi:10.3762/bjoc.10.293

• Dresden, Germany Max Bergmann Center of Biomaterials MBC, Technische Universität Dresden, Budapester Str. 27, 01069 Dresden, Germany Chair of General Biochemistry, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany 10.3762/bjoc.10.293 Abstract Due to their outstanding properties

Synthesis of a resin monomer-soluble polyrotaxane crosslinker containing cleavable end groups

• Ji-Hun Seo,
• Shino Nakagawa,
• Koichiro Hirata and
• Nobuhiko Yui

Beilstein J. Org. Chem. 2014, 10, 2623–2629, doi:10.3762/bjoc.10.274

• Ji-Hun Seo Shino Nakagawa Koichiro Hirata Nobuhiko Yui Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, 101-0062, Japan Tokuyama Dental Corp. Research Institute, Tsukuba, 300-4247, Japan 10.3762/bjoc.10.274 Abstract A resin monomer-soluble polyrotaxane

Bifunctional dendrons for multiple carbohydrate presentation via carbonyl chemistry

• Davide Bini,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2014, 10, 1686–1691, doi:10.3762/bjoc.10.177

• the development of smart biomaterials for regenerative medicine [9][10][11][12]. Beside the variation of carbohydrate residues in glycoconjugates, a key issue in the recognition process is their spatial topographical presentation eliciting high affinity recognition events. In order to better

Bis(β-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the decontamination of biological toxins of the Ricinus communis family

• Hirofumi Dohi,
• Takeru Kanazawa,
• Akihiro Saito,
• Keita Sato,
• Hirotaka Uzawa,
• Yasuo Seto and
• Yoshihiro Nishida

Beilstein J. Org. Chem. 2014, 10, 1504–1512, doi:10.3762/bjoc.10.155

• interest [7][8]. In particular, multivalent biomaterials carrying more than two carbohydrate ligands have been designed [9][10][11][12][13][14][15] and proven to enhance protein–carbohydrate interactions by means of glycocluster effects [16][17][18]. More recently, our research group has reported on

An economical and safe procedure to synthesize 2-hydroxy-4-pentynoic acid: A precursor towards ‘clickable’ biodegradable polylactide

• Quanxuan Zhang,
• Hong Ren and
• Gregory L. Baker

Beilstein J. Org. Chem. 2014, 10, 1365–1371, doi:10.3762/bjoc.10.139

• remove any possible oxidants (like HNO2 and HNO3) to prevent decomposition of product 1 while drying under vacuum. Overall, this procedure represents a practical and economical approach to conveniently synthesize precursor 1 for preparation of ‘clickable’ polylactide biomaterials. Experimental General

Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

• Fabrizio Chiodo,
• Marco Marradi,
• Javier Calvo,
• Eloisa Yuste and
• Soledad Penadés

Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136

• Fabrizio Chiodo Marco Marradi Javier Calvo Eloisa Yuste Soledad Penades Laboratory of GlycoNanotechnology, Biofunctional Nanomaterials Unit, CIC biomaGUNE, Paseo Miramón 182, 20009, San Sebastián, Spain Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Paseo

The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels

• Jiayang Li,
• Yi Kuang,
• Junfeng Shi,
• Yuan Gao,
• Jie Zhou and
• Bing Xu

Beilstein J. Org. Chem. 2013, 9, 908–917, doi:10.3762/bjoc.9.104

• supramolecular hydrogels. Sharing similar features with the extracellular matrices of tissues (e.g., consisting of three-dimensional networks and a significant amount of water), hydrogels have become an attractive choice for developing biomaterials for a variety of applications. For example, hydrogels have

• the polymer backbone remains a nontrivial issue. Despite being constantly improved, these limitations call for the exploration and development of new functional biomaterials and therapeutics. The recent development of supramolecular nanofibers and hydrogels [10][11][12][13][14][15][16][17][18][19][20

• ][21][22][23][24][25] presents an exciting opportunity for developing new types of biomaterials [26][27][28][29]. While the early works have centered on the use of nanofibers of oligopeptides to form hydrogels as a passive scaffold for tissue engineering and drug delivery [30], the seminal work by

A peptidic hydrogel that may behave as a “Trojan Horse”

• Nicola Castellucci,
• Giorgio Sartor,
• Natalia Calonghi,
• Carola Parolin,
• Giuseppe Falini and
• Claudia Tomasini

Beilstein J. Org. Chem. 2013, 9, 417–424, doi:10.3762/bjoc.9.44

• transition. They have a wide range of applications in biomaterials, biosensors, tissue engineering, and drug delivery [12][13][14][15]. The interest in these materials as tools for the controlled release of drugs is mainly linked to their capability to release gel-entrapped molecules in response to external

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• ; cross-linked polymers; cyclodextrin; drug delivery; nanosponges; Review Recent advances in nanotechnology demonstrate the increased attention that is now being paid to the supramolecular assembly of simple components for therapeutic and diagnostic purposes. The design of new biomaterials based on

• nanoscale structural characteristics can be expected to provide many potential applications in the field of nanomedicine. Cyclodextrins [1][2][3] are nanometric biomaterials with a close relationship between molecular status and supramolecular properties. They are a class of cyclic glucopyranose oligomers

Influence of cyclodextrin on the solubility of a classically prepared 2-vinylcyclopropane macromonomer in aqueous solution

• Helmut Ritter,
• Jia Cheng and
• Monir Tabatabai

Beilstein J. Org. Chem. 2012, 8, 1528–1535, doi:10.3762/bjoc.8.173

• chains. Graft copolymers have found many applications, for example in the field of coatings, adhesives, compatibilizers, emulsifiers or biomaterials [1]. For the synthesis of graft copolymers, free radical copolymerization of macromonomers with suitable low molecular weight vinylmonomers is a widely

Low-generation dendrimers with a calixarene core and based on a chiral C₂-symmetric pyrrolidine as iminosugar mimics

• Marco Marradi,
• Stefano Cicchi,
• Francesco Sansone,
• Alessandro Casnati and
• Andrea Goti

Beilstein J. Org. Chem. 2012, 8, 951–957, doi:10.3762/bjoc.8.107

• thanks the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). AC and MM acknowledge COST action CM1102. AC and FS also acknowledge PRIN200858SA98 for partial support.

Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment

• Christiane E. Kupper,
• Ruben R. Rosencrantz,
• Birgit Henßen,
• Helena Pelantová,
• Stephan Thönes,
• Anna Drozdová,
• Vladimir Křen and
• Lothar Elling

Beilstein J. Org. Chem. 2012, 8, 712–725, doi:10.3762/bjoc.8.80

• Christiane E. Kupper Ruben R. Rosencrantz Birgit Henssen Helena Pelantova Stephan Thones Anna Drozdova Vladimir Kren Lothar Elling Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, Aachen, 52074

Amphiphilic dendritic peptides: Synthesis and behavior as an organogelator and liquid crystal

• Baoxiang Gao,
• Hongxia Li,
• Defang Xia,
• Sufang Sun and
• Xinwu Ba

Beilstein J. Org. Chem. 2011, 7, 198–203, doi:10.3762/bjoc.7.26

• ; liquid crystal; organogels; Introduction Peptide self-assembly has drawn a significant attention due to potential applications, especially in the fields of biomedicine and bionanotechnology [1][2][3]. Programmed self-assembly of peptides into highly ordered nanostructures creates biomaterials that

ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering

• Franziska Weichelt,
• Solvig Lenz,
• Stefanie Tiede,
• Ingrid Reinhardt,
• Bernhard Frerich and
• Michael R. Buchmeiser

Beilstein J. Org. Chem. 2010, 6, 1199–1205, doi:10.3762/bjoc.6.137

• materials with a specific surface structure and porosity, however, would allow for the differentiation of mesenchymal stem cells into osteoblasts, and thus the development of scaffold materials for bone regeneration. Ideal biomaterials for bone TE should be non-immunogeneic, biodegradable, highly

Pyridinium based amphiphilic hydrogelators as potential antibacterial agents

• Sayanti Brahmachari,
• Sisir Debnath,
• Sounak Dutta and
• Prasanta Kumar Das

Beilstein J. Org. Chem. 2010, 6, 859–868, doi:10.3762/bjoc.6.101

• pyridinium compounds. Most importantly, the hydrogelation ability along with the inherent antibacterial properties of the present amphiphiles make them interesting scaffolds for biomedicinal applications. Application of antibacterial biomaterials becomes more versatile and significant only when they are also

• cells. The antibacterial activity conjugated with low cytotoxicity and water gelation ability makes this class of compound an attractive target for the development of antibacterial biomaterials. Experimental Materials Myristic acid, palmitic acid, stearic acid and ethyl bromide were purchased from SRL

Hydroxyapatite supported caesium carbonate as a new recyclable solid base catalyst for the Knoevenagel condensation in water

• Monika Gupta,
• Rajive Gupta and
• Medha Anand

Beilstein J. Org. Chem. 2009, 5, No. 68, doi:10.3762/bjoc.5.68

• catalytically active centres [3][4][5]. Hydroxyapatites can be used as biomaterials, adsorbents, ion-exchangers and catalysts. So far, a few excellent applications of hydroxyapatites as catalysts or catalytic supports have emerged [6]. Solid base catalysts are known to display unique catalytic performance

Functional properties of metallomesogens modulated by molecular and supramolecular exotic arrangements

• Alessandra Crispini,
• Mauro Ghedini and
• Daniela Pucci

Beilstein J. Org. Chem. 2009, 5, No. 54, doi:10.3762/bjoc.5.54

• complexes suggesting that, through the careful choice of the molecular building blocks, cyclopalladated mesogens represent multifunctional biomaterials. They bear at the same time the active principle and the membrane-compatible delivery component, and are becoming innovative tools in establishing new and

A divergent asymmetric approach to aza-spiropyran derivative and (1S,8aR)-1-hydroxyindolizidine

• Jian-Feng Zheng,
• Wen Chen,
• Su-Yu Huang,
• Jian-Liang Ye and
• Pei-Qiang Huang

Beilstein J. Org. Chem. 2007, 3, No. 41, doi:10.1186/1860-5397-3-41

• variable optical density, and photomechanical biomaterials etc. And (1R,8aS)-1-hydroxyindolizidine (3) has been postulated to be a biosynthetic precursor of hydroxylated indolizidines such as (+)-lentiginosine 1, (−)-2-epilentiginosine 2 and (−)-swainsonine, which are potentially useful antimetastasis

• ,[11] and photomechanical biomaterials etc.[12] On the other hand, hydroxylated indolizidines [13][14][15][16][17][18][19][20] such as castanospermine, (−)-swainsonine, (+)-lentiginosine (1) [21][22][23] and (−)-2-epilentiginosine (2) [21][22][23][24][25][26] constitute a class of azasugars showing