Cyanothioacetamides as a synthetic platform for the synthesis of aminopyrazole derivatives

• Valeriy O. Filimonov,
• Alexandra I. Topchiy,
• Vladimir G. Ilkin,
• Tetyana V. Beryozkina and
• Vasiliy A. Bakulev

Beilstein J. Org. Chem. 2023, 19, 1191–1197, doi:10.3762/bjoc.19.87

• exhibit a variety of biological activity. Their application is known in pharmacy [1][2][3][4] and agro-industry [5][6][7][8]. Especially such compounds are used to protect plants from insects and weeds (Figure 1). Thus, pinoxaden is a commercially available inhibitor of acetyl-CoA carboxylase and affects

Back to the future: Why we need enzymology to build a synthetic metabolism of the future

• Tobias J. Erb

Beilstein J. Org. Chem. 2019, 15, 551–557, doi:10.3762/bjoc.15.49

• the periphery of the CETCH cycle to keep the system running. Another problem was posed by the promiscuous activity of propionyl-CoA carboxylase with acetyl-CoA. This problem was solved by replacing the problematic reaction with another enzymatic route. Finally, an initially promiscuous acyl-CoA

Biocatalysis for the application of CO₂ as a chemical feedstock

• Apostolos Alissandratos and
• Christopher J. Easton

Beilstein J. Org. Chem. 2015, 11, 2370–2387, doi:10.3762/bjoc.11.259

• as a renewable chemical feedstock, greatly enabling a sustainable carbon bio-economy. Keywords: biocatalysis; carboxylase; CO2 transformation; formate dehydrogenase; RuBisCO; Introduction Depletion of fossil-fuel feedstocks and pollution resulting from their unsustainable processing and use

• number of carboxylases, phosphoanhydride bonds in ATP are hydrolysed to drive CO2 transformation through various molecular mechanisms. For example, biotin carboxylase catalysed reactions proceed through electrophilic activation of CO2 to carboxyphosphate to facilitate an attack by a nucleophile [28]. In

• generated through oxidation of inorganic chemicals (chemoautotrophs) [47]. As detailed in Scheme 1, the carbon fixation step entails the carboxylation of ribulose-1,5-bisphosphate (1), generating two equivalents of 3-phosphoglycerate (2) and is catalysed by ribulose-1,5-bisphosphate carboxylase oxygenase

The myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030

• Tobias A. M. Gulder,
• Snežana Neff,
• Traugott Schüz,
• Tammo Winkler,
• René Gees and
• Bettina Böhlendorf

Beilstein J. Org. Chem. 2013, 9, 2579–2585, doi:10.3762/bjoc.9.293

• with cell membrane stability [21]. Inhibition of acetyl-CoA carboxylase is exerted by soraphen A1α (2), which has been shown to be a potent and broad spectrum fungicide [22][23]. The most dominant target of myxobacterial antifungal agents, however, is the mitochondrial respiratory chain [21]. The

Synthesis and antibacterial activity of monocyclic 3-carboxamide tetramic acids

• Yong-Chul Jeong and
• Mark G. Moloney

Beilstein J. Org. Chem. 2013, 9, 1899–1906, doi:10.3762/bjoc.9.224

• inhibitor) [3], R207910 (an ATP synthase inhibitor) [4] and moiramide B (a bacterial acetyl-CoA carboxylase inhibitor) [5]. Both natural 3-acyltetramic acids, for example streptolydigin 1a (bacterial RNA polymerase (RNAP) inhibitory activity) [6] and kibdelomycin 1b (bacterial type II topoisomerase