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Search for "chemical pathway" in Full Text gives 6 result(s) in Beilstein Journal of Organic Chemistry.
Pd-catalyzed dehydrogenative arylation of arylhydrazines to access non-symmetric azobenzenes, including tetra-ortho derivatives
Beilstein J. Org. Chem. 2025, 21, 2234–2242, doi:10.3762/bjoc.21.170
- arylhydrazine and aryl bromide. b) Proposed chemical pathway for azobenzene synthesis, including side-product formation as determined by GC/MS analysis. Scope of aryl bromides in palladium-catalyzed dehydrogenative C–N coupling with phenylhydrazine (1a). aUsing 2 equiv of 1a. Scope of arylhydrazines in
Synthesis, biological and electrochemical evaluation of glycidyl esters of phosphorus acids as potential anticancer drugs
Beilstein J. Org. Chem. 2025, 21, 1909–1916, doi:10.3762/bjoc.21.148
- carbon, scan rate: 0.1 V/s, pH 6.7. Chemical structure of alkylating fragment of 1–3 and the associated chemical pathway of its covalent attachment to HSA. Synthesis of glycidyl esters of phosphorus acids 1–3. IC50 values (μM ± SD) for glycidyl esters of phosphorus acids 1–3 in human skin fibroblasts
Chemical and chemoenzymatic routes to bridged homoarabinofuranosylpyrimidines: Bicyclic AZT analogues
Beilstein J. Org. Chem. 2022, 18, 95–101, doi:10.3762/bjoc.18.10
- chemoenzymatic method was found to be superior over the chemical method in respect of the number of synthetic steps and overall yield of the final product. Keywords: bicyclic AZT analogues; bridged homoarabinofuranosylpyrimidine nucleosides; chemical pathway; Lipozyme® TL IM; regioselective enzymatic
- , trihydroxy nucleoside 14b was protected with TBDPS to carry out the synthesis of the target nucleoside monomer 9b through a chemical pathway. However, the poor yield of this reaction compelled us to abandon the route as high solubility of the TBDPS-protected dihydroxy nucleoside in aqueous phase withstood
- % yields, respectively (Scheme 5). The overall yields of the synthesis of nucleosides 9a and 9b starting from diacetone ᴅ-glucofuranose following the classical chemical pathway were found to be 24.2 and 24.4%, respectively. The stereochemistry at the C5′ carbon in bicyclic homonucleosides 9a,b was
Regioselective chemoenzymatic syntheses of ferulate conjugates as chromogenic substrates for feruloyl esterases
Beilstein J. Org. Chem. 2021, 17, 325–333, doi:10.3762/bjoc.17.30
- groups of the glycoside and the O-acetyl group of the ferulate moiety. The fact that lipase-catalyzed transesterification obviates the need for protection and deprotection is a considerable advantage because the final deprotection in the chemical pathway is complicated by the presence of another ester
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway
Beilstein J. Org. Chem. 2013, 9, 900–907, doi:10.3762/bjoc.9.103
- host defense, immunity, and inflammation and even have implications in cancer. Thus, dysregulation of NF-κB activity contributes to numerous autoimmune and inflammatory disease states. With this, the availability of new chemical pathway probes will further enhance understanding of this complex network
Photoinduced homolytic C–H activation in N-(4-homoadamantyl)phthalimide
Beilstein J. Org. Chem. 2011, 7, 270–277, doi:10.3762/bjoc.7.36
- for the abstraction. Keywords: homoadamantanes; photoinduced H-abstraction; phthalimides; Introduction Since the pioneering work of Ciamican and Paterno [1][2], the photochemistry of ketones has been intensively studied [3][4][5][6]. One important chemical pathway for the deactivation of ketones
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