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Search for "diindolylmethane" in Full Text gives 3 result(s) in Beilstein Journal of Organic Chemistry.

Green and sustainable approaches for the Friedel–Crafts reaction between aldehydes and indoles

  • Periklis X. Kolagkis,
  • Eirini M. Galathri and
  • Christoforos G. Kokotos

Beilstein J. Org. Chem. 2024, 20, 379–426, doi:10.3762/bjoc.20.36

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  • reaction between aldehydes with indoles, while focusing on the more environmentally friendly methods developed over the years. Keywords: aldehyde; BIMs; Friedel–Crafts reaction; green chemistry; indole; Review Medicinal properties In recent years, diindolylmethane (DIM, 1) and its derivatives known as
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Published 22 Feb 2024

Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center

  • Thanigaimalai Pillaiyar,
  • Masoud Sedaghati,
  • Andhika B. Mahardhika,
  • Lukas L. Wendt and
  • Christa E. Müller

Beilstein J. Org. Chem. 2021, 17, 1464–1475, doi:10.3762/bjoc.17.102

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  • affinity; cannabinoid receptors; diindolylmethane; unsymmetrical 3,3'-diindolylmethane; Introduction Diindolylmethanes (DIMs) represent an important class of indole alkaloids, that are constituents of pharmaceuticals [1][2][3][4][5][6][7] and agrochemicals [8][9]. DIM derivatives possess a variety of
  • -phenylpropan-1-ol (1j, 1.0 g, 2.7 mmol) were reacted with indole (2a, 0.40 g, 3.4 mmol; and 0.347 g, 2.9 mmol, respectively). The reactions proceeded without significant loss in efficiency, affording 1.2 g of 3a (92% yield) and 1.10 g of 3ad (87% yield). The unsubstituted diindolylmethane (I, Figure 1) was
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Published 18 Jun 2021

Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K2CO3/n-Bu4PBr in water

  • Thanigaimalai Pillaiyar,
  • Masoud Sedaghati and
  • Gregor Schnakenburg

Beilstein J. Org. Chem. 2020, 16, 778–790, doi:10.3762/bjoc.16.71

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  • advantages of this protocol. Keywords: C–C-bond formation; C3-funtionalization of indole; diindolylmethane; Friedel–Crafts reaction; indole; indole-3-carbinol; large-scale synthesis; recyclability; Introduction (1H-Indol-3-yl)methanols have emerged as versatile pre-electrophiles for C–C functionalization
  • this reaction. The base-catalyzed reaction has a benefit because it may avoid the formation of diindolylmethane and biindoles as byproducts [28]. Although these methods were useful, they have limitations and drawbacks, which are the use of organic solvents [24], difficulties in recyclability of the
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Published 20 Apr 2020
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