Trichloroacetic acid fueled practical amine purifications

• Aleena Thomas,
• Baptiste Gasch,
• Enzo Olivieri and
• Adrien Quintard

Beilstein J. Org. Chem. 2022, 18, 225–231, doi:10.3762/bjoc.18.26

• success. Keywords: amines; decarboxylation; eco-compatible; out of equilibrium; purification; Introduction Isolation of pure amines from reaction mixtures or natural extracts is crucial in modern organic chemistry. However, the most widely applied methods for these purifications have remained unchanged

• . Most notably, this step can go through a liquid–liquid separation that requires multiple operations generating large amounts of waste notably arising from the different organic and aqueous layers. In the context of the development of more eco-compatible organic synthesis limiting the number of

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

• Soumyadip Basu,
• Sauvik Chatterjee,
• Suman Ray,
• Suvendu Maity,
• Prasanta Ghosh,
• Asim Bhaumik and
• Chhanda Mukhopadhyay

Beilstein J. Org. Chem. 2022, 18, 133–142, doi:10.3762/bjoc.18.14

• important 1,4-DHPs. Under these aspects, we utilized a heterogeneous and magnetically separable Ni–chitosan nanocatalyst under ultrasonic radiation in a green solvent to develop a new eco-compatible synthesis. A small amount of catalyst was required for the reaction, and the catalyst could be reused in up

Preparation of mono-substituted malonic acid half oxyesters (SMAHOs)

• Tania Xavier,
• Sylvie Condon,
• Christophe Pichon,
• Erwan Le Gall and
• Marc Presset

Beilstein J. Org. Chem. 2021, 17, 2085–2094, doi:10.3762/bjoc.17.135

• known as alkyl hydrogen malonates or hemimalonates, constitute an attractive class of pronucleophiles in the design of eco-compatible syntheses [1]. Indeed, they can serve as efficient precursors of ester enolates through decarboxylation [2][3], generally using a substoichiometric amount of a weak base

Enzymatic synthesis of glycosides: from natural O- and N-glycosides to rare C- and S-glycosides

• Jihen Ati,
• Pierre Lafite and
• Richard Daniellou

Beilstein J. Org. Chem. 2017, 13, 1857–1865, doi:10.3762/bjoc.13.180

• molecular biology have allowed the emergence of biocatalytic procedures. Enzymes have proven to be efficient synthetic tools for the eco-compatible synthesis of many classes of compounds. Non-organic solvents, mild experimental conditions, and high regio- or stereospecificity of the biocatalysed reaction

An eco-compatible strategy for the diversity-oriented synthesis of macrocycles exploiting carbohydrate-derived building blocks

• Sushil K. Maurya and
• Rohit Rana

Beilstein J. Org. Chem. 2017, 13, 1106–1118, doi:10.3762/bjoc.13.110

• , Himachal Pradesh, 176 061, India 10.3762/bjoc.13.110 Abstract An efficient, eco-compatible diversity-oriented synthesis (DOS) approach for the generation of library of sugar embedded macrocyclic compounds with various ring size containing 1,2,3-triazole has been developed. This concise strategy involves

• potential of the new eco-compatible approach for the macrocyclic library generation. Keywords: carbohydrate; click chemistry; diversity-oriented synthesis; macrocycles; ring-closing metathesis; Introduction Macrocycles offer very complex molecular architectures with a diverse range of ring sizes decorated

Silica-supported sulfonic acids as recyclable catalyst for esterification of levulinic acid with stoichiometric amounts of alcohols

• Raimondo Maggi,
• N. Raveendran Shiju,
• Veronica Santacroce,
• Giovanni Maestri,
• Franca Bigi and
• Gadi Rothenberg

Beilstein J. Org. Chem. 2016, 12, 2173–2180, doi:10.3762/bjoc.12.207

• the scale of these preparations did not boosted demand yet. However, the seek to develop more eco-compatible solvents might grant to levulinates a novel route of application. By tailoring their physicochemical properties they could become complementary to common esters and other solvents, which might

Organic gelators and hydrogelators

• Jean-Pierre Desvergne

Beilstein J. Org. Chem. 2010, 6, 846–847, doi:10.3762/bjoc.6.99

• an understanding of the mechanism of gelation. It is also important to develop future green gelators for eco-compatible applications. This thematic series on organogels and hydrogels will address these various points with a particular emphasis on the molecular requirements on the gelling ability, the