Beilstein J. Org. Chem.2020,16, 1579–1587, doi:10.3762/bjoc.16.130
powerful synthetic tools.
Keywords: halomethylcoumarin; Morita–Baylis–Hillman adducts; organocatalyst; phosphonium salt; triazolation; Introduction
The presence of versatile functional groups in close proximity classifies Morita–Baylis–Hillman adducts as privileged key scaffolds for synthetic organic
PDF
Graphical Abstract
Scheme 1:
Literature-reported cycloaddition reactions of MBH acetates involving azides and alkynes [24-28].
Beilstein J. Org. Chem.2012,8, 1200–1207, doi:10.3762/bjoc.8.133
halomethylcoumarin and highly stabilized nucleophiles or amines [6][7][8][9][10][11][12][13][14][15]. Due to the sensitivity and toxicity of related benzyl halides, there has been interest in catalytically activating hydroxymethylarene and heteroarenes (e.g., benzyl alcohol derivatives) toward reactions with
PDF
Graphical Abstract
Figure 1:
Representative biologically active aminomethylcoumarins.