Beilstein J. Org. Chem.2013,9, 197–203, doi:10.3762/bjoc.9.23
: asymmetric synthesis; benzimidazole; host-directed; myxovirus; small molecule inhibitor; Introduction
Myxoviruses are divided into two evolutionarily distinct yet related families: the orthomyxoviridae, which is composed largely of the influenza viruses, and the paramyxoviridae, which includes respiratory
improved solubilities relative to 1, particularly at acidic pH values, but also at pH 7.4.
Conclusion
We have extended our previously published work on host-directed inhibitors of myxovirus replication by preparing analogues that positively address the poor aqueous solubility of 1 (JMN3-003) while
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Graphical Abstract
Figure 1:
Structure of first-generation lead compound 1.