Gold film- catalysed benzannulation by Microwave- Assisted, Continuous Flow Organic Synthesis (MACOS)

• Gjergji Shore,
• Michael Tsimerman and
• Michael G. Organ

Beilstein J. Org. Chem. 2009, 5, No. 35, doi:10.3762/bjoc.5.35

• not only a catalytic effect, but also a pivotal heating effect supplied by the film. More recently we have shown that a gold film in the same flow reactor is highly effective for hydrosilylation reactions [25] and we were interested both to expand the use of gold films in synthesis using MACOS and in

Radical carbonylations using a continuous microflow system

• Takahide Fukuyama,
• Md. Taifur Rahman,
• Naoya Kamata and
• Ilhyong Ryu

Beilstein J. Org. Chem. 2009, 5, No. 34, doi:10.3762/bjoc.5.34

• [12]. The Seeberger group reported reduction and hydrosilylation using TTMSS in a microflow system [13]. In our study, we found that the combination of a rapidly decomposing radical initiator with a microreaction device allowed the reactions to be completed in a very short period of time giving good

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

• David M. Hodgson and
• Leonard H. Winning

Beilstein J. Org. Chem. 2008, 4, No. 38, doi:10.3762/bjoc.4.38

• rearranged–trapped azacycle 13. This result, in conjunction with the silylated by-products recovered from these reactions, supports the hypothesis that (reversible) hydrosilylation of the electrophile may be a significant competing pathway in these reactions. With a viable method for the deoxygenation

The use of silicon- based tethers for the Pauson- Khand reaction

• Adrian P. Dobbs,
• Ian J. Miller and
• Saša Martinović

Beilstein J. Org. Chem. 2007, 3, No. 21, doi:10.1186/1860-5397-3-21

• : lithium-halogen exchange, Grignard-based methodologies and catalytic hydrosilylation. The approach decided upon used the Grignard and hydrosilylation reactions. Work by Swisher and Chen showed that by using a solution of chloroplatinic acid (H2PtCl6 in isopropyl alcohol) compounds containing terminal

• double bonds could be added catalytically to silane species to yield the substituted chlorosilanes.[33][34] This methodology was coupled with a Grignard reaction to attempt to cyclise the substituted silane (Scheme 18). The catalytic hydrosilylation using chloroplatinic acid as the catalyst proved to be

Conformational rigidity of silicon- stereogenic silanes in asymmetric catalysis: A comparative study

• Sebastian Rendler and
• Martin Oestreich

Beilstein J. Org. Chem. 2007, 3, No. 9, doi:10.1186/1860-5397-3-9

• metal-catalyzed asymmetric transformations as exemplified by (1) the hydrosilylation of alkenes constituting a chirality transfer from silicon to carbon and (2) the kinetic resolution of racemic mixtures of alcohols by dehydrogenative silicon-oxygen coupling. In this investigation, a cyclic and a

• investigations directed towards the mechanistic elucidation of the origin of the chirality transfer in a palladium-catalyzed hydrosilylation, [10] we had to perform an extensive screening of silicon-stereogenic tertiary silanes. On that occasion, we became aware that a similar level of stereoselection was

• -catalyzed kinetic resolution of donor-functionalized alcohols capable of two-point binding. The reagent-controlled hydrosilylation of norbornene derivative 2 with silane 1a proceeds with a perfect chirality transfer (rac-1a → rac-3a, Scheme 1). [8] Mechanistic investigation of the nature of the