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Search for "indolone" in Full Text gives 5 result(s) in Beilstein Journal of Organic Chemistry.
Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated heterocycles
Beilstein J. Org. Chem. 2024, 20, 118–124, doi:10.3762/bjoc.20.12
- Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China 10.3762/bjoc.20.12 Abstract A visible-light-promoted research protocol for constructing dihydropyrido[1,2-a]indolone skeletons is herein described proceeding through a cascade cyclization mediated by trifluoromethyl
- enables a rapid access to heterocycles containing a trifluoromethyl group. Keywords: cascade reaction; indole derivatives; photocatalysis; radical chain process; trifluoromethylation; Introduction Dihydropyrido[1,2-a]indolone (DHPI) skeletons are commonly found in natural products and pharmaceutical
- and at the same time improved cell membrane permeability. Therefore, it became a commonly used strategy to modify medicine candidates [22][23][24]. Based on these advantages, we envisioned a one-step synthesis of dihydropyrido[1,2-a]indolone skeletons utilizing an indole substrate and a
Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor
Beilstein J. Org. Chem. 2020, 16, 1722–1731, doi:10.3762/bjoc.16.144
- construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying the substrates, the substituents, or the heating mode, it is possible to selectively synthesize indole, indolone (1,5,6,7-tetrahydroindol-4-one), or cinnoline (5,6,7,8
- -tetrahydrocinnoline) derivatives in moderate to excellent yields. Keywords: cinnoline; 1,4-diketone; indole; indolone; N-heterocycle; Introduction Nitrogen-containing heterocycles are widespread in plenty of molecules of interest, either in materials science, optics, electronics, or biology [1][2][3][4]. They are
- also very useful building blocks to create more sophisticated organic molecules. Therefore, the search for efficient methods for the synthesis of nitrogen-containing heterocycles is crucial to both organic and medicinal chemists. Among these, indole, indolone (1,5,6,7-tetrahydroindol-4-one), and
Fates of imine intermediates in radical cyclizations of N-sulfonylindoles and ene-sulfonamides
Beilstein J. Org. Chem. 2015, 11, 1649–1655, doi:10.3762/bjoc.11.181
- substrates were chosen to provide imines with spirocyclic indoline and indolone substituents. We discovered that these imines are rather reactive, being either reduced or undergoing an unusual hydration and retro-Claisen-type reaction of an amide. Here we report the results of these experiments, which add to
Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo
Beilstein J. Org. Chem. 2015, 11, 481–492, doi:10.3762/bjoc.11.54
- -mediated thermal reactions of allylic bromides with 1 at 70 °C were promising and allowed facile, but limited, access to new 1-allyl-5'-allyloxy-3',4'-dihydrospiroindoline-pyrido[1,2-a]indolone derivatives and pyridoindolo-azepino[1,2-a]indol-11(7H)-one derivatives, the reactions were incomplete, yields
One-pot three-component synthesis and photophysical characteristics of novel triene merocyanines
Beilstein J. Org. Chem. 2014, 10, 599–612, doi:10.3762/bjoc.10.51
- quantum chemical calculations on the DFT level (B3LYP functional, 6-31G* basis set) [40]. The computed Kohn–Sham frontier molecular orbitals of compound 8a clearly indicate a charge transfer from the aminovinyl dominated donor fragment in the HOMO to the indolone-centered LUMO, which is generally
- conclusion, we enabled the diversity-oriented synthesis of novel triene merocyanines with intense bathochromic absorption by a consecutive three-component insertion–coupling–addition sequence in good to excellent yields. While the N-substituent on the indolone moiety exerts minute electronic differences in
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