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Search for "peptide-based" in Full Text gives 35 result(s) in Beilstein Journal of Organic Chemistry.
Come-back of phenanthridine and phenanthridinium derivatives in the 21st century
Beilstein J. Org. Chem. 2014, 10, 2930–2954, doi:10.3762/bjoc.10.312
- , characterised by the specific fluorescence band sensitive to the pH as well as on the interactions with ds-DNA. Interestingly, all peptide-based phenanthridines revealed excellent water solubility combined with low in vitro toxicity, thus being good candidates for development of new safe fluorimetric DNA and
Automated solid-phase peptide synthesis to obtain therapeutic peptides
Beilstein J. Org. Chem. 2014, 10, 1197–1212, doi:10.3762/bjoc.10.118
- osteoporosis, cardiovascular diseases and inflammation can be treated by peptide-based drugs [4][5]. Within the last decades, the fast development of omics technologies such as genomics, proteomics and transcriptomics led to the identification of a great number of target peptides or proteins [6]. This trend
- revolutionized by new methods and strategies for automated approaches, which simplifies peptide manufacturing. Combined with the mentioned advantages of peptide-based drugs, their application as novel biopharmaceuticals is pushed forward. Within the last years, the global market for peptide therapeutics expanded
New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei
Beilstein J. Org. Chem. 2013, 9, 1643–1651, doi:10.3762/bjoc.9.188
- , Indonesia), which proved to be rich in aurantosides [6] and 4-methylene steroids [18], while polyketide macrolides and peptide-based derivatives were extremely rare if not absent. Remarkably, the chemical analysis of a different specimen of T. swinhoei, collected in the same area as the previous one
Efficient regio- and stereoselective access to novel fluorinated β-aminocyclohexanecarboxylates
Beilstein J. Org. Chem. 2013, 9, 1164–1169, doi:10.3762/bjoc.9.130
- protein–ligand or protein–protein interactions, thereby determining thermal or metabolic stabilities, which is of great importance in peptide-based drug research [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. These changes in properties may be more
Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups
Beilstein J. Org. Chem. 2012, 8, 1753–1764, doi:10.3762/bjoc.8.200
- innate immune system, the name “antimicrobial peptides” (abbreviated as AMPs) defines a larger group of peptides that also encompasses synthetic peptides, and peptidomimetics, for example. Among these, synthetic peptide-based antimicrobial agents are especially interesting because isolation and/or
Synthetic studies towards bottromycin
Beilstein J. Org. Chem. 2012, 8, 1652–1656, doi:10.3762/bjoc.8.189
- endothiopeptide and ring closure between proline and glycine. The same group also undertook some modifications on the natural product [26]. Results and Discussion Our group is also involved in the synthesis of peptide-based natural products [27][28][29][30][31][32], and of course the structure of bottromycin is
Parallel solid-phase synthesis of diaryltriazoles
Beilstein J. Org. Chem. 2012, 8, 1027–1036, doi:10.3762/bjoc.8.115
- peptide-based compounds [8], can be overcome by compounds stabilized by non-natural amino acids [9] or cross-linked between side chains and the backbone [10]. Replacement of the complete backbone by a nonpeptidic scaffold, which positions side chains in the typical i, i+3 and i+7 arrangement of an α-helix
Exceptionally small supramolecular hydrogelators based on aromatic–aromatic interactions
Beilstein J. Org. Chem. 2011, 7, 167–172, doi:10.3762/bjoc.7.23
- represents the lowest molecular weight (MW = 295.33 g/mol) peptide-based hydrogelator prepared to date. The supramolecular hydrogels were characterized by transmission electron micrograph (TEM) and fluorescence spectroscopy, and the results obtained by both techniques correlate well with their rheological
- possibility of peptide-based hydrogelators that are smaller than the aroyl L-cystine noted above. Here, we reported the systematic synthesis and examination of a series of phenylalanine derivatives and the identification of the lowest molecular weight peptide-based hydrogelator (MW = 295.33 g/mol) produced to
- phenyl groups. Conclusion In summary, we have demonstrated that an aromatic group (fluorenyl, naphthyl, naphthalenoxyl, or cinnamoyl) covalently attached to phenylalanine gives rise to a series of new low molecular weight hydrogelators and the identification of the lowest molecular weight peptide-based
Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels
Beilstein J. Org. Chem. 2010, 6, 973–977, doi:10.3762/bjoc.6.109
- networks as a result of intimate interactions between gelator molecules. Keywords: amino acid; histidine; hydrogel; peptide-based surfactant; soft matter; supramolecular; Introduction Hydrogels continue to attract much interest due to their versatile applications in tissue engineering, biosensing, drug
An enantiomerically pure siderophore type ligand for the diastereoselective 1 : 1 complexation of lanthanide(III) ions
Beilstein J. Org. Chem. 2009, 5, No. 78, doi:10.3762/bjoc.5.78
- C81H99N15O9 [M + Na]+: m/z = 1448.7642; found 1448.7639. HRMS (ESI): calcd. for C81H99N15O9 [M + H]+: m/z = 1426.7823; found 1426.7808. HRMS (ESI): [M + 2Na]++: m/z = 735.8739; found 735.8767. Synthesis and characterization of macrocyclic imidazole peptide based tris(N,N-diethyl-8-hydroxyquinoline-2
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