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Search for "physicochemical characterization" in Full Text gives 12 result(s) in Beilstein Journal of Organic Chemistry.
Improved synthesis and physicochemical characterization of the selective serotonin 2A receptor agonist 25CN-NBOH
Beilstein J. Org. Chem. 2026, 22, 175–184, doi:10.3762/bjoc.22.11
Thiadiazino-indole, thiadiazino-carbazole and benzothiadiazino-carbazole dioxides: synthesis, physicochemical and early ADME characterization of representatives of new tri-, tetra- and pentacyclic ring systems and their intermediates
Beilstein J. Org. Chem. 2025, 21, 2220–2233, doi:10.3762/bjoc.21.169
- metabolic stability of the most promising derivatives was also determined using human liver microsomes. Keywords: early ADME characterization; Fischer indole cyclization; heterocycles; indoles; lead-likeness; new ring systems; physicochemical characterization; Introduction Considering the published
- physicochemical characterization, we conducted standardized metabolic stability assessments on pooled human liver microsome (HLM) isolates of the primary and secondary lead compounds identified during the solubility and permeability studies. The measured values are summarized in the last column of Table 2 and
C2 to C6 biobased carbonyl platforms for fine chemistry
Beilstein J. Org. Chem. 2025, 21, 2103–2172, doi:10.3762/bjoc.21.165
Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
Beilstein J. Org. Chem. 2021, 17, 1385–1391, doi:10.3762/bjoc.17.97
- moderate antifungal activity. A recent find of a Marasmius species in Northern Thailand led, however, to the isolation and identification of five novel derivatives of this carotane-type sesquiterpenoid. The present study is dedicated to describing their isolation, and biological and physicochemical
- characterization. Results Structure elucidation of the secondary metabolites 2–6 Preparative HPLC of the supernatant crude extract of a submerged cultivation of Marasmius sp. strain MFLUCC 14-0681 in ZM½ media led to the isolation of six carotane sesquiterpenoids, fulvoferruginins A–F (1–6, Figure 1). The first
Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa
Beilstein J. Org. Chem. 2019, 15, 2782–2789, doi:10.3762/bjoc.15.270
- isolation as well as biological and physicochemical characterization. Results and Discussion The fruiting bodies of the fungal specimen MUCL56074 were extracted with acetone and subsequently purified via preparative HPLC, which led to the isolation of five previously undescribed secondary metabolites, 1–5
Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)
Beilstein J. Org. Chem. 2018, 14, 1554–1562, doi:10.3762/bjoc.14.132
- distinctive peak and UV spectrum in the HPLC. Its production, isolation, biological and physicochemical characterization is reported in the current paper. Results and Discussion Lanyamycin (1/2, Figure 1) was isolated as a pale-yellow amorphous substance. On silica gel TLC it had an Rf value of 0.43 with
Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies
Beilstein J. Org. Chem. 2018, 14, 838–848, doi:10.3762/bjoc.14.69
- dairy products has been studied thoroughly in recent years. Although the physicochemical characterization of the inclusion compound of cholesterol in β-CD has been achieved by various methods, no crystal structure has been determined so far. We report here the crystal structure of the inclusion compound
Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B
Beilstein J. Org. Chem. 2016, 12, 2523–2534, doi:10.3762/bjoc.12.247
- arises from the amidocarbinol ether (±)-9 after protonation and loss of ethanol. The planar structure of the cation explains the lack of stereoselectivity observed in the reaction. Physicochemical measurements Physicochemical characterization of dracocephins A and B was also carried out. The relevant
Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection
Beilstein J. Org. Chem. 2015, 11, 763–772, doi:10.3762/bjoc.11.86
- comparable with dPG-NH2 50% and 90%. Average particle size and surface charges of AAdPG/siRNA polyplexes The appropriate particle size and surface charge are critical characteristics of nanoplexes for efficient transfection [29]. Physicochemical characterization of AAdPG/siRNA polyplexes was conducted using
Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin
Beilstein J. Org. Chem. 2015, 11, 204–212, doi:10.3762/bjoc.11.22
- nanocapsules, physicochemical characterization of CPT-loaded CD nanocapsules, determination of CPT loading, in vitro CPT release studies, CPT stability in simulated GI fluids and cytotoxicity, anticancer efficacy and permeability assay of CD nanocapsules. Supporting Information File 140: Experimental data
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway
Beilstein J. Org. Chem. 2013, 9, 900–907, doi:10.3762/bjoc.9.103
Inclusion of the insecticide fenitrothion in dimethylated-β-cyclodextrin: unusual guest disorder in the solid state and efficient retardation of the hydrolysis rate of the complexed guest in alkaline solution
Beilstein J. Org. Chem. 2013, 9, 106–117, doi:10.3762/bjoc.9.14
- (2,6-di-O-methyl)-β-CD (DIMEB), the latter molecule having properties intermediate between those of the native and fully methylated counterparts [10]. The preparation and physicochemical characterization of the crystalline inclusion complex DIMEB·1 are presented, this complex crystallizing in a novel
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