Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents

• Rodolfo H. V. Nishimura,
• Thiago dos Santos,
• Valter E. Murie,
• Luciana C. Furtado,
• Leticia V. Costa-Lotufo and
• Giuliano C. Clososki

Beilstein J. Org. Chem. 2021, 17, 2968–2975, doi:10.3762/bjoc.17.206

• ). The EGFR inhibitor drugs bearing the 4-anilinoquinazoline moiety did not show potent cytotoxic activity against T98G cells (21.3 µM for erlotinib, and 37.8 µM for gefitinib). However, the tubulin polymerization inhibitor (verubulin), which contains 4-anilinoquinazoline in its chemical structure, was

A new protocol for the synthesis of 4,7,12,15-tetrachloro[2.2]paracyclophane

• Donghui Pan,
• Yanbin Wang and
• Guomin Xiao

Beilstein J. Org. Chem. 2016, 12, 2443–2449, doi:10.3762/bjoc.12.237

• reduced pressure. Thus, a chromatographic purification was not necessary in the improved dimerization protocol. To suppress the polymerization and to improve the yield of the dimer product, we attempted the addition of a polymerization inhibitor. As expected, the addition of 3 mol % phenothiazine

• substituted [2.2]paracyclophanes were synthesized from substituted (4-methylbenzyl)trimethylammonium bromides in aqueous sodium hydroxide solution in the presence of a polymerization inhibitor (Table 4). It was found that the yields of dimer products were improved dramatically compared to the results obtained

• existing bromination methods. In the Winberg elimination–dimerization step, 35% yield of 4,7,12,15-tetrachloro[2.2]paracyclophane was obtained from 2,5-dichloro-(4-methylbenzyl)trimethylammonium bromide and aqueous sodium hydroxide solution in the presence of a polymerization inhibitor, which was about two