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Search for "pregabalin" in Full Text gives 5 result(s) in Beilstein Journal of Organic Chemistry.

Palladium-catalyzed three-component radical-polar crossover carboamination of 1,3-dienes or allenes with diazo esters and amines

  • Geng-Xin Liu,
  • Xiao-Ting Jie,
  • Ge-Jun Niu,
  • Li-Sheng Yang,
  • Xing-Lin Li,
  • Jian Luo and
  • Wen-Hao Hu

Beilstein J. Org. Chem. 2024, 20, 661–671, doi:10.3762/bjoc.20.59

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  • owing to their wide applications in medicinal chemistry [1][2][3][4][5]. γ- and ε-AA derivatives are widely distributed in peptide natural products, bioactive molecules, and drugs, such as pregabalin, baclofen, ε-aminocaproic acid and lysine (Scheme 1a) [6][7][8][9][10][11][12]. The number of reported
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Published 27 Mar 2024

Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs

  • Jongwoo Son

Beilstein J. Org. Chem. 2021, 17, 1733–1751, doi:10.3762/bjoc.17.122

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  • source to execute facile C–H azidation of pharmaceutical-like complex molecules (Scheme 3) [38]. In this study, the regioselectivity is governed not only by electronic and steric effects of the manganese catalysts 5 and 10 but also by the electronic properties of the substrates. Pregabalin is an
  • anticonvulsant drug used to treat epilepsy and anxiety disorders [39], and an analogue of pregabalin was transformed to azidated derivative 11a. It is noteworthy that positional selectivity was observed for the α-position of the carbamate functional group due to the stabilization of the carbon radical by the
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Published 26 Jul 2021

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

  • Guido Gambacorta,
  • James S. Sharley and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

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Published 18 May 2021

Investigations towards the stereoselective organocatalyzed Michael addition of dimethyl malonate to a racemic nitroalkene: possible route to the 4-methylpregabalin core structure

  • Denisa Vargová,
  • Rastislav Baran and
  • Radovan Šebesta

Beilstein J. Org. Chem. 2018, 14, 553–559, doi:10.3762/bjoc.14.42

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  • catalyst. Furthermore, specific organocatalysts can provide respective stereoisomers of the key Michael adduct in up to 99:1 er. Keywords: kinetic resolution; Michael addition; organocatalysis; pregabalin; squaramide; Introduction Asymmetric organocatalysis has considerably broadened possibilities for
  • , seizures, or epilepsy. Several mono- and dialkyl substituted derivatives, known as gabapentinoids, are currently used in clinical praxis. Important members of this class such as phenibut, gabapentin, or pregabalin have anticonvulsant, anxiolytic, and analgesic mode of actions [5]. Pregabalin (Figure 1) is
  • one of the most widely used medicines for the treatment of neuropathic pains and partial seizures. It is also known that the (S)-enantiomer is approximately 10 times more active than the (R)-enantiomer. Medicinal properties of alkyl derivatives of pregabalin were also investigated. Wustrow and co
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Published 05 Mar 2018

Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis of meso-cyclic anhydrides

  • Lingjun Xu,
  • Shuwen Han,
  • Linjie Yan,
  • Haifeng Wang,
  • Haihui Peng and
  • Fener Chen

Beilstein J. Org. Chem. 2018, 14, 309–317, doi:10.3762/bjoc.14.19

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  • pharmaceuticals, such as γ-aminobutyric acid (GABA) and γ-amino-β-hydroxybutyric acid (GABOB) analogues (baclofen HCl and pregabalin) [51][52][53][54], HMG-CoA reductase inhibitors (“statins”) [55][56][57], etc. The generality and scope of this methodology was further demonstrated in the alcoholysis of 8a with
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Published 31 Jan 2018
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