Beilstein J. Org. Chem.2021,17, 2773–2780, doi:10.3762/bjoc.17.187
; triazenes; triazines; Introduction
The structural motif of pyrazolotriazines, particularly the pyrazolotriazinones, has drawn attention regarding a possible application as therapeutic agents due to manifold biological activities. Amongst other known constitutional isomers such as pyrazolo[4,3-e][1,2,4
possible, especially pyrazolotriazines with an aliphatic substituent on the pyrazole-nitrogen (5e–i) degraded rapidly in contact with air/moisture.
The conversion of the regioisomeric compounds 10 to 6 failed under the conditions described in Scheme 4. The triazene protective group could not be cleaved
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Graphical Abstract
Scheme 1:
Synthesis of 3,6-dihydro-4H-pyrazolo[3,4-d][1,2,3]triazin-4-ones 2a,b by diazotization of 3-amino-1H...
Beilstein J. Org. Chem.2018,14, 203–242, doi:10.3762/bjoc.14.15
substituted pyrazoloazines by a broad range of organic reactions by means of 5-aminopyrazole as a precursor.
Keywords: 5-aminopyrazoles; fused pyrazole derivatives; pyrazolopyridines; pyrazolopyrimidines; pyrazolotriazines; Review
Pyrazole and its derivatives are known to exhibit significant biological and
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Graphical Abstract
Figure 1:
Selected examples of drugs with fused pyrazole rings.