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Search for "zinc chloride" in Full Text gives 34 result(s) in Beilstein Journal of Organic Chemistry.
Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents
Beilstein J. Org. Chem. 2011, 7, 1261–1277, doi:10.3762/bjoc.7.147
- chloride and LiCl. Under these conditions, the relatively unreactive aryl bromides and chlorides readily react. Furthermore, sensitive functionalities are tolerated since the reactive arylmagnesium species generated is immediately trapped with zinc chloride (Scheme 7) [22]. Thus, methyl 3-bromobenzoate (37
- fewer functional groups. Thus, methyl esters react rapidly with arylmagnesium reagents at 0 °C. In order to solve this problem, we have performed a Barbier-type preparation of aryl and heteroaryl zinc reagents by treating the aryl bromide or chloride with magnesium turnings in the presence of zinc
Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles
Beilstein J. Org. Chem. 2011, 7, 824–830, doi:10.3762/bjoc.7.94
- intermolecular reaction using dimethylzinc in toluene for the transmetalation step. These new experiments produced results similar to the reactions in the presence of zinc chloride (Table 2). Next, we investigated the scope of the intramolecular reaction (Table 4). Both tetrahydrofuran and tetrahydropyran
- intermediates can be transmetalated in situ with dimethylzinc or zinc chloride, which facilities the cross-coupling process to give N-unprotected homoallylic amines after aqueous workup. All products were isolated as single regio- and diastereoisomers, and the regioselectivity of the allylation step was shown
- Peter Wipf Marija D. Manojlovic Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA 10.3762/bjoc.7.94 Abstract The one-pot hydrozirconation of allenes and nitriles followed by an in situ transmetalation of the allylzirconocene with dimethylzinc or zinc
A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals
Beilstein J. Org. Chem. 2011, 7, 570–577, doi:10.3762/bjoc.7.66
- single diastereomer upon chelation with zinc chloride. TEMPO oxidation gave lactone 1, which corresponds to the reported structure of cephalosporolide H. A more detailed discussion is found in our earlier report [28]. Two mechanistic alternatives (Scheme 7) are proposed for the conversion of 6 → 17 in
SbCl3-catalyzed one-pot synthesis of 4,4′-diaminotriarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies
Beilstein J. Org. Chem. 2011, 7, 135–144, doi:10.3762/bjoc.7.19
- acids such as zinc chloride, zeolites, montmorillonite K-10, and polymer-supported sulfonic acid (NKC-9) [35][36][37][38][39][40]. Microwave-assisted synthesis of DTMs in the presence of aniline hydrochloride has also been described [41]. Recently, bismuth(III) nitrate and zirconium(IV) dichloride oxide
A short and efficient synthesis of valsartan via a Negishi reaction
Beilstein J. Org. Chem. 2010, 6, No. 27, doi:10.3762/bjoc.6.27
- -pentanoyl-L-valinate (5) [9] in 70% yield. Ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) [10] with n-butyllithium at 25 °C followed by treatment with zinc chloride at −20 °C gave the desired organozinc chloride compound. Coupling of the latter with aryl bromide 5 in presence of a catalytic amount
Preparation and Diels–Alder/cross coupling reactions of a 2-diethanolaminoboron- substituted 1,3-diene
Beilstein J. Org. Chem. 2009, 5, No. 45, doi:10.3762/bjoc.5.45
- boronate 2: A mixture of magnesium (1.0 g, 41.1 mmol), 1,2-dibromoethane (0.5 mL), and THF (10 mL) was refluxed under nitrogen for 15 min to activate the magnesium. To the mixture anhydrous zinc chloride (0.6 g) in THF (60 mL) was added and reflux was continued for another 15 min. 2-Chloro-1,3-butadiene
Ru-catalyzed dehydrogenative coupling of carboxylic acids and silanes - a new method for the preparation of silyl ester
Beilstein J. Org. Chem. 2008, 4, No. 27, doi:10.3762/bjoc.4.27
- are expensive. A few examples have been disclosed for dehydrosilylation reactions catalyzed by metal salts such as zinc chloride [26] or, more frequently, by transition metals and metal complexes such as [CuH(Ph3P)] [34], HPtCl6, Rh and Pd [36][37][38][39][40][41][42][43][44], Co2(CO)6 [45], Cu(Ph3P
Diels- Alder reactions using 4,7-dioxygenated indanones as dienophiles for regioselective construction of oxygenated 2,3-dihydrobenz[f]indenone skeleton
Beilstein J. Org. Chem. 2008, 4, No. 15, doi:10.3762/bjoc.4.15
- lacking NOE data. Next, the effect of Lewis acid on the regioselectivity was examined. At first, zinc chloride (ZnCl2), an effective catalyst on DAR of benz[f]indenone and Danishefsky-type diene [21], was chosen. Addition of a catalytic amount of ZnCl2 at −78 °C did not affect the regioselectivity (entry
The tert- amino effect in heterocyclic chemistry: Synthesis of new fused pyrazolinoquinolizine and 1,4-oxazinopyrazoline derivatives
Beilstein J. Org. Chem. 2007, 3, No. 43, doi:10.1186/1860-5397-3-43
- malononitrile and cyanoacetamide followed by cyclisation using anhydrous zinc chloride. Background The N-phenyl-3-substituted 5-pyrazolone derivatives are organic compounds that have been known since 1883; they are very useful as intermediates for pharmaceuticals and are used as anti-inflammatory agents and
- Knoevenagel condensation reactions with malonodinitrile to give the corresponding pyrazolin-5-ylmethylenemalonodinitriles 4a, which in turn cyclized in the presence of anhydrous zinc chloride to get the corresponding pyrazolinoquinolizines 6a and 1,4-oxazinopyrazolines 6e in refluxing toluene (Scheme 1). The
- conditions. Similarly, when cyanoacetamide was reacted in place of malonodinitrile and the Knoevenagel product 4b thus obtained was further heated in the presence of zinc chloride, the corresponding pyrazolinoquinolizine 6a was obtained in 60% yield. The structures of the end products obtained were
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