Antibiotic and cytotoxic peptides

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Editor: Prof. Norbert Sewald
Universität Bielefeld
 
Through evolution, nature has provided practically all organisms with secondary metabolites: chemical compounds that provide the producing species with specific protective mechanisms or other advantages. Among these, there are, e.g., peptides that display antibiotic/antimicrobial activity. These have been isolated from plants, invertebrates, vertebrates, and humans, but also from microorganisms. Some antibiotic peptides are an essential part of innate immunity, which has evolved in most organisms to combat microbial challenge. In addition, antimicrobial peptides sometimes also display cytotoxicity against mammalian cells.
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Antibiotic and cytotoxic peptides

  • Norbert Sewald

Beilstein J. Org. Chem. 2012, 8, 1144–1145, doi:10.3762/bjoc.8.127

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Published 24 Jul 2012

Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics

  • Workalemahu M. Berhanu,
  • Mohamed A. Ibrahim,
  • Girinath G. Pillai,
  • Alexander A. Oliferenko,
  • Levan Khelashvili,
  • Farukh Jabeen,
  • Bushra Mirza,
  • Farzana Latif Ansari,
  • Ihsan ul-Haq,
  • Said A. El-Feky and
  • Alan R. Katritzky

Beilstein J. Org. Chem. 2012, 8, 1146–1160, doi:10.3762/bjoc.8.128

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Published 24 Jul 2012

Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity

  • Marta De Zotti,
  • Barbara Biondi,
  • Cristina Peggion,
  • Matteo De Poli,
  • Haleh Fathi,
  • Simona Oancea,
  • Claudio Toniolo and
  • Fernando Formaggio

Beilstein J. Org. Chem. 2012, 8, 1161–1171, doi:10.3762/bjoc.8.129

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Published 24 Jul 2012

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

  • Evan F. Haney,
  • Leonard T. Nguyen,
  • David J. Schibli and
  • Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

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Published 24 Jul 2012

Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations

  • John B. Bremner,
  • Paul A. Keller,
  • Stephen G. Pyne,
  • Mark J. Robertson,
  • K. Sakthivel,
  • Kittiya Somphol,
  • Dean Baylis,
  • Jonathan A. Coates,
  • John Deadman,
  • Dharshini Jeevarajah and
  • David I. Rhodes

Beilstein J. Org. Chem. 2012, 8, 1265–1270, doi:10.3762/bjoc.8.142

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Published 09 Aug 2012

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

  • James R. Cochrane,
  • Dong Hee Yoon,
  • Christopher S. P. McErlean and
  • Katrina A. Jolliffe

Beilstein J. Org. Chem. 2012, 8, 1344–1351, doi:10.3762/bjoc.8.154

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Published 21 Aug 2012

Synthetic studies towards bottromycin

  • Stefanie Ackermann,
  • Hans-Georg Lerchen,
  • Dieter Häbich,
  • Angelika Ullrich and
  • Uli Kazmaier

Beilstein J. Org. Chem. 2012, 8, 1652–1656, doi:10.3762/bjoc.8.189

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Published 01 Oct 2012

Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

  • H. Bauke Albada,
  • Alina-Iulia Chiriac,
  • Michaela Wenzel,
  • Maya Penkova,
  • Julia E. Bandow,
  • Hans-Georg Sahl and
  • Nils Metzler-Nolte

Beilstein J. Org. Chem. 2012, 8, 1753–1764, doi:10.3762/bjoc.8.200

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Published 15 Oct 2012

Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

  • Jan Hoyer,
  • Ulrich Schatzschneider,
  • Michaela Schulz-Siegmund and
  • Ines Neundorf

Beilstein J. Org. Chem. 2012, 8, 1788–1797, doi:10.3762/bjoc.8.204

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Published 18 Oct 2012

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120

  • Julia Meier,
  • Kristin Kassler,
  • Heinrich Sticht and
  • Jutta Eichler

Beilstein J. Org. Chem. 2012, 8, 1858–1866, doi:10.3762/bjoc.8.214

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Published 31 Oct 2012

Total synthesis and biological evaluation of fluorinated cryptophycins

  • Christine Weiß,
  • Tobias Bogner,
  • Benedikt Sammet and
  • Norbert Sewald

Beilstein J. Org. Chem. 2012, 8, 2060–2066, doi:10.3762/bjoc.8.231

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Published 23 Nov 2012

Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology

  • Jan Anderl,
  • Hartmut Echner and
  • Heinz Faulstich

Beilstein J. Org. Chem. 2012, 8, 2072–2084, doi:10.3762/bjoc.8.233

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Published 27 Nov 2012

The multicomponent approach to N-methyl peptides: total synthesis of antibacterial (–)-viridic acid and analogues

  • Ricardo A. W. Neves Filho,
  • Sebastian Stark,
  • Bernhard Westermann and
  • Ludger A. Wessjohann

Beilstein J. Org. Chem. 2012, 8, 2085–2090, doi:10.3762/bjoc.8.234

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Published 28 Nov 2012
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