Biomolecular systems
Biomolecular systems research is currently one of the most important scientific areas, interconnecting researchers from medicine, pharmacology, biology and chemistry. Based on its interdisciplinary background it covers, but is not limited to, the identification of core structures, the design and (automated) synthesis of targeted molecules, as well as their investigation in biological systems. The current Thematic Series aims to provide an insight into this highly diverse and interesting scientific field.
- Letter
- Published 28 Apr 2017
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Scheme 1: Retrosynthetic analysis of D-manno-heptulose.
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Scheme 2: Initial attempt on the synthesis of the C4 aldehyde from D-lyxose (5).
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Scheme 3: Synthesis of differentially protected ketoheptose building block 2.
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Scheme 4: Synthesis of D-manno-heptulose (1).
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- Full Research Paper
- Published 11 May 2017
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Figure 1: Expression of GFP-tagged GAT1 in infected insect cells. (A) Flow cytometry analysis of GAT1/GFP in ...
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Figure 2: Protein fingerprinting. (A) Coomassie Blue staining of the GAT1/GFP protein from infected Sf9 cells...
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Figure 3: Isolation of the GAT1/GFP fusion protein from Sf9 cells by mAb-GFP-conjugated affinity column chrom...
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Figure 4: Purification of the GAT1/GFP fusion protein from Sf9 cells by SE-FPLC. (A) Elution profile of GAT1/...
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Figure 5: Characterization of the GAT1/GFP fusion protein after SE-FPLC. (A) Elution profile of GAT1/GFP prot...
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- Full Research Paper
- Published 16 May 2017
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Figure 1: Inhibitors of glucosaminidases.
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Scheme 1: Synthesis of disaccharide donors.
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Figure 2: Proposed mechanism and origin of the selectivity.
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Figure 3: Synthesis of TMG-chitotriomycin precursor 7.
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Figure 4: Synthess of TMG-chitotriomycin (1).
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- Review
- Published 24 May 2017
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Figure 1: Schematic overview on the glyco-gold nanoparticles synthetic approaches.
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Figure 2: Glyco-gold nanoparticles: metallic core and glyco-coating contribute to the production of the versa...
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Figure 3: The protein–carbohydrate interactions analyzed by conventional dark field microscopy. The interacti...
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Figure 4: Copper-free cycloaddition (SPAAC) of azido galactoside on cyclooctyne and schematic depiction of Au...
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Figure 5: A photoaffinity labeling (PAL) approach based on glyco-gold nanoparticles is able to recognize and ...
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Figure 6: Design of the fiber-type “Sugar Chips”. AuNPs are firstly immobilized on an optical fiber functiona...
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Figure 7: Design of GAuNPs, displaying both sugar residues and the anticancer Au(I)PPh3. Reprinted with permi...
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- Full Research Paper
- Published 13 Jun 2017
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- Letter
- Published 16 Jun 2017
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Figure 1: Comparative analysis of hapalindole-type alkaloids and their BGCs in two welwitindolinone producers...
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Figure 2: a) In vitro characterizations show that WelO5* has comparable activity to both 1 and 2, distinct fr...
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Figure 3: In vitro characterization of a WelO5 variant with enhanced specificity towards 1. All of the HPLC d...
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