Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• , with diameters ranging from 0.4 to 100 nm and lengths extending from a few micrometers to several centimeters [7]. The functionalization of CNTs is achieved by surface modification through various methods including covalent bonding, adsorption, and detection group attachment [7][8]. Palve et al

• -volume ratio, enhancing sensitivity and functionalization capabilities. Baetsen-Young et al. used dextrin-capped gold nanoparticles (12 nm) with ssDNA to detect the presence of Pseudoperonospora cubensis DNA, where the results show the ability to detect 18 spores/µL crude extractions [11]. However, the

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• PAN nanofibers, enhancing the hydrophilicity and antibacterial properties of the membrane [20]. Elimelech’s group introduced copper nanoparticles (Cu NPs) onto the surface of thin-film composite (TFC) polyamide RO membranes through a method involving electrostatic functionalization. The functionalized

• evidence of the successful sequential functionalization of the CTA membrane. In addition, at a temperature of 800 °C, both the CTA and PCTA films exhibit a residual mass of 0%, indicating complete decomposition or volatilization, leaving no significant inorganic residues. In contrast, the Ag@PCTA film

• further functionalization (Figure 4c). This PDA layer imparts functional groups, such as catechol and amino groups, which facilitate the subsequent reduction and immobilization of Ag nanoparticles. Upon Ag deposition, the PCTA membrane’s surface exhibits evenly distributed Ag nanoparticles nestled within

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• significant implications for developing new theories of light–matter interaction and various applications such as surface functionalization, microfabrication, and developing advanced materials with tailored surface properties. Depicts the experimental setup utilized in the fabrication process of laser-induced

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• [158] and surface chemical functionalization [159], which helps to achieve high drug levels at the target site. Several strategies have been developed to obtain nanoscale or micrometric gels instead of macroscopic networks formed by a simple gelation process [20][160][161]. In emulsion polymerization

Electronic and optical properties of chloropicrin adsorbed ZnS nanotubes: first principle analysis

• Prakash Yadav,
• Boddepalli SanthiBhushan and
• Anurag Srivastava

Beilstein J. Nanotechnol. 2025, 16, 1184–1196, doi:10.3762/bjnano.16.87

• , which can be tailored through rational design. By precisely controlling their size, shape, synthesis conditions, and functionalization, nanomaterials can achieve extraordinary magnetic, electrical, optical, mechanical, sensing, anticancer, and photocatalytic properties that significantly differ from

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• materials nanoarchitectonics. Cornez, Azzaroni, and colleagues describe the preparation and functionalization of highly organized layered multilayer structures by layer-by-layer organization of lipid-like surfactants and polyelectrolytes (Figure 15) [276]. In this study, hydrophobic lamellar domains were

• nanoarchitectonics, enabling the versatile design of layered heterosupramolecular assemblies. This enables the sophisticated functionalization of the supramolecular organization of multicompartmental interfacial structures. The fabrication of functional layered structures by means of soft materials

A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light

• Cristina Parisi,
• Loredana Ferreri,
• Tassia J. Martins,
• Francesca Laneri,
• Samantha Sollima,
• Antonina Azzolina,
• Antonella Cusimano,
• Nicola D’Antona,
• Grazia M. L. Consoli and
• Salvatore Sortino

Beilstein J. Nanotechnol. 2025, 16, 1003–1013, doi:10.3762/bjnano.16.75

• spectra that confirmed the exhaustive functionalization of the calixarene upper rim (Figures S1–S7, Supporting Information File 1). The NOPD 2 contains the same chromophoric motif as our recently reported NOPD [59], differing only by having a C4 alkyl chain instead of a C8. This choice was motivated to

Synchrotron X-ray photoelectron spectroscopy study of sodium adsorption on vertically arranged MoS₂ layers coated with pyrolytic carbon

• Alexander V. Okotrub,
• Anastasiya D. Fedorenko,
• Anna A. Makarova,
• Veronica S. Sulyaeva,
• Yuliya V. Fedoseeva and
• Lyubov G. Bulusheva

Beilstein J. Nanotechnol. 2025, 16, 847–859, doi:10.3762/bjnano.16.64

• graphite lattice (D mode) [40]. The position of the G mode is higher than the position of the G peak at 1582 cm–1 for crystalline graphite and graphene [41], indicating the disorder in the layers and their functionalization. In fact, the intensity ratio of the D to G peaks (ID/IG) of 0.87 is relatively

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• functionalization of SF facilitate its usage in optics as a biosensor and implantable device [92]. Malinowski et al. showed that conventional transparent films often lack adequate haze, but SF films exhibit ultrahigh optical transparency (>93%) and transmission haze (>65%). In this study, soft lithography was used

• PU degrades in living beings [142]. Several modifications can be made to PU to make it an excellent material for wound healing and skin substitute by blending, surface functionalization, and adding active moieties. PU with hydrophilic groups and long chains forms fewer crystals, making it more

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

• manage NDs such as Alzheimer’s. In this review, we systematically categorize NPs used for the diagnosis and inhibition of AβOs based on their composition and functionalization. This bifurcation allows for a clearer understanding of the diverse mechanisms and applications of NPs in addressing AD. We have

• size, shape, and surface properties, as these factors collectively influence how they interact with amyloidogenic proteins. Smaller NPs can infiltrate and break early-stage oligomers, whereas differences in shape influence binding efficiency and selectivity. Surface functionalization, such as

• , resulting in less stable aggregates. These findings emphasize that nanoparticle size and shape are key factors in controlling amyloid aggregation, providing valuable insights for designing nanoparticle-based therapies for AD [94]. Beyond size and shape, surface functionalization plays a crucial role in

Functionalized gold nanoflowers on carbon screen-printed electrodes: an electrochemical platform for biosensing hemagglutinin protein of influenza A H1N1 virus

• Carlos Enrique Torres-Méndez,
• Sharmilee Nandi,
• Klara Martinovic,
• Patrizia Kühne,
• Yifan Liu,
• Sam Taylor,
• Maria Lysandrou,
• Maria Ines Berrojo Romeyro Mascarenhas,
• Viktoria Langwallner,
• Javier Enrique Sebastián Alonso,
• Ivana Jovanovic,
• Maike Lüftner,
• Georgia-Vasiliki Gkountana,
• David Bern,
• Abdul-Raouf Atif,
• Ehsan Manouchehri Doulabi,
• Gemma Mestres and
• Masood Kamali-Moghaddam

Beilstein J. Nanotechnol. 2025, 16, 540–550, doi:10.3762/bjnano.16.42

• was amplified by functionalization of the gold nanoflowers with 4-aminothiophenol, which resulted in a 100-fold decrease of the charge transfer resistance due to a tunneling effect. Subsequently, monoclonal antibodies against H1 were immobilized on the surface via covalent amide bond formation

• transducer system of our biosensor is based on low-cost carbon screen printed electrodes (CSPEs) modified with functionalized gold nanoflowers (AuNFs). The complex morphology and surface functionalization of the nanoparticles with 4-aminothiophenol (4-ATP) significantly increased the surface area and the

• largest change in the CV was observed after the functionalization of the AuNFs with 4-ATP through stable Au–S bonds. In this case, the peak-to-peak separation for the 4-ATP/AuNFs/CSPE was 0.16 V, showing that the redox reversibility for the [Fe(CN)6]3−/4− pair and the current response of the electrode

Performance optimization of a microwave-coupled plasma-based ultralow-energy ECR ion source for silicon nanostructuring

• Joy Mukherjee,
• Safiul Alam Mollick,
• Tanmoy Basu and
• Tapobrata Som

Beilstein J. Nanotechnol. 2025, 16, 484–494, doi:10.3762/bjnano.16.37

• nanopatterning and nanoscale functionalization have garnered significant interest, owing to their broad applications in DNA origami [10], tuning of wettability [11] and electrical and magnetic anisotropy [12][13], isolated dot formation [1], nanoscale plasmonic arrays [14], and field emission [15]. Thus, ion

Engineered PEG–PCL nanoparticles enable sensitive and selective detection of sodium dodecyl sulfate: a qualitative and quantitative analysis

• Soni Prajapati and
• Ranjana Singh

Beilstein J. Nanotechnol. 2025, 16, 385–396, doi:10.3762/bjnano.16.29

• inherent toxicity, and their post-synthesis functionalization is laborious for selective detection [25][26]. Furthermore, alternatives such as polymer nanoparticles emerged as potential candidates for detecting contaminants such as SDS. Fu et al. developed a method for detecting SDS using polyethyleneimine

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• . Key strategies for improvement are analyzed, including material modifications through blending and structural modifications like fiber orientation and multilayer constructions, and surface modifications such as coating and functionalization. The review also covers advanced characterization methods to

Preferential enrichment and extraction of laser-synthesized nanoparticles in organic phases

• Theo Fromme,
• Maximilian L. Spiekermann,
• Florian Lehmann,
• Stephan Barcikowski,
• Thomas Seidensticker and
• Sven Reichenberger

Beilstein J. Nanotechnol. 2025, 16, 254–263, doi:10.3762/bjnano.16.20

• ) functionalization of the nanoparticles have been observed, which ultimately should affect their lipophilicity and, hence, colloidal stability in apolar or polar solvents. Two-phase liquid systems and the possibility to transfer the surfactant-free nanoparticles from one liquid phase into another remain practically

• potential values close to 0 V are used during ablation in such TMS systems. Conclusion While the research activities on LAL in solvents have highlighted the importance and role of chemical reactions on particle size and chemical functionalization (e.g., carbon shell) of the gained colloids, the influence of

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• physicochemical characterization, including the formulations exposed to irradiation under the same conditions. For physicochemical characterization of the formulations, different techniques were used by which successful functionalization of the CNs and TMZ loading were confirmed and visualized; no significant

• changes in the structure of the CNs and TMZ after irradiation were observed. With single and dual functionalization, formulations with relatively high TMZ loading efficiency and drug content were prepared. They exhibited homogeneous particle size distributions and mean particle sizes and surface charges

• for active agent loading and functionalization with (intra)cellular component targeting ligands, and extremely small size for crossing the blood–brain barrier (BBB) and targeted delivery to the brain. The hydrophobic nature of the CNs offers good membrane permeability. Through chemical modifications

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• modification of the synthesized MOFs and allows for the synthesis of multifunctional frameworks [32][33][34][35]. Alternatively, MOFs can undergo post-synthetic modification to achieve similar functionalization without the risk of degrading functionalized linkers during high-temperature and high-pressure MOF

• , reported in Figure 3. Many of these studies focus on CO2 capture. The key benefit of using MOFs in MMMs rather than simple inorganic particles is their unusually high surface areas with adjustable pore sizes and unique functionalization opportunities [86]. As described in section 2, this allows for

• functionalization of MOFs before MMM preparation can enhance MOF–polymer compatibility by enabling the formation of hydrogen bonds between the MOF and the hydrogen bond donors in the polymer matrix [33]. 3.5 Importance of interfacial morphology An optimal MOF–polymer matrix interface, schematically illustrated in

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• masks the functionalization of groups coated on the NC surface. The formation of this corona acts as a clearance signal, prompting macrophages to recognize and engulf NCs [34]. The denser the proteins adsorbed onto the NC surface, the faster the uptake into the liver and spleen [35][36]. Several factors

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol

• Akash Kumar,
• Ridhima Chadha,
• Abhishek Das,
• Nandita Maiti and
• Rayavarapu Raja Gopal

Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124

• . The functionalization of AgNPs with ʟ-carnosine was validated through Fourier-transform infrared spectroscopy (FTIR, Thermo Scientific Nicolet iS5, USA). For this, 10 mg of air-dried nanopowder was placed over a diamond, and the software (OMNIC™) was run over the spectral range of 400–4000 cm−1. The

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• the functionalization of the outer surface of nanoparticles with specific molecules or ligands to impart desired properties or functionalities. This process plays a crucial role in enhancing the targeting, stability, and therapeutic efficacy of PLHNPs for drug/phytochemical delivery. Surface

• , instability at physiological pH, and rapid metabolism hinder its clinical utilization [125]. Yang et al. fabricated HCT-encapsulated cyclic RGD peptide (c(RGDyk))-modified PLHNPs for improved therapeutic efficacy against BC [126]. Surface functionalization and PEG conjugation did not modulate the drug release

Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study

• Kamal Kumar,
• Nora H. de Leeuw,
• Jost Adam and
• Abhishek Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116

• two-dimensional (2D) material, consisting of a single layer of sp2-hybridized carbon atoms arranged together in a hexagonal lattice [1]. Because of its extraordinary electrical and thermal conductivity, large surface area, and easy chemical functionalization, it provides a variety of applications in

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• conducted for polymeric nanoparticles to understand their role in N2B delivery. For instance, Gabold et al. reported the preparation of protein-loaded chitosan NPs decorated with transferrin as a proof-of-concept study to demonstrate a versatile surface functionalization that can also be suitable for N2B

• critical literature reviews on N2B delivery of peptides and proteins. Considering the recent advancements and publications in the field, we highlight N2B delivery of biopharmaceuticals while emphasizing mAbs, RNA delivery, and NP functionalization techniques for better targeting the brain [150]. Despite

• treating glioblastoma [161]. The delivery of RNA can also be increased by functionalization. One of the most popular functionalization choices is a 29 amino-acid peptide derived from the rabies virus glycoprotein (RVG29) as it enhances brain targeting [162]. Therefore, researchers combined RVG29 and RNA

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• to use. These biomimetic surface functionalization steps were confirmed by several complimentary surface analysis techniques. The wettability of each surface was probed with water contact angle measurements, while the chemical composition of the layer was determined by X-ray photoelectron

• at a pH of 8.5. PDA-coated samples were rinsed with DI and then introduced to a 10 mM aqueous solution of 1H,1H,2H,2H-perfluorodecanethiol (FDT) (Sigma-Aldrich, St. Louis, MO) and triethylamine [19]. Following FDT functionalization, the samples were thoroughly rinsed and sonicated in DI water and

• composition of the layer was determined by XPS. Surface roughness was evaluated using AFM to confirm successful formation of a porous structure. Finally, ordering of specific chemical groups within our PDA SLIPS layer was explored via SFG spectroscopy. Initially, each functionalization step was assessed

Green synthesis of carbon dot structures from Rheum Ribes and Schottky diode fabrication

• Muhammed Taha Durmus and
• Ebru Bozkurt

Beilstein J. Nanotechnol. 2024, 15, 1369–1375, doi:10.3762/bjnano.15.110

• nanostructures are carbon dot structures (CDs). These structures have recently become a common field of study because of their properties including chemical stability, water solubility, and easy synthesis and functionalization. Carbon dots, were first discovered by Xu and his working group [1] while purifying