Cellulose as a photocatalyst support material: extraction, structural features, and environmental applications

• Yee Teng Lim,
• Nur Farhana Jaafar,
• Azizul Hakim Lahuri and
• Endang Tri Wahyuni

Beilstein J. Nanotechnol. 2026, 17, 635–652, doi:10.3762/bjnano.17.44

• solve a major challenge in photocatalytic treatment, which is the recovery of TiO2 from water after use, thereby making the process more efficient and easier to manage [102]. This strategy also reduces the risk of TiO2 nanoparticle contamination in treated water, an important factor in protecting human

Two-step laser synthesis of Ag@TiO₂ nanomaterials for the photocatalytic degradation of rhodamine B

• Marija Kovačević,
• Miloš Tošić,
• Rafaela Radičić,
• Vladimir Rajić,
• Nikša Krstulović,
• Miloš Momčilović and
• Sanja Živković

Beilstein J. Nanotechnol. 2026, 17, 622–634, doi:10.3762/bjnano.17.43

• different materials or did not include controlled metal deposition prior to nanoparticle formation, particularly when using picosecond laser ablation. In this work, we introduce a two-step strategy combining nanosecond PLD and picosecond PLAL. This approach enables controlled silver loading prior to

• nanoparticle formation, leading to improved control over nanoparticle structure and photocatalytic performance. Results and Discussion SEM analysis The surface morphology of PLD-prepared samples was analyzed using SEM-EDS (Figure 2 and Figure 3). SEM images of the sample surface after deposition of silver on

• times greater in the Ag@TiO2 2000p than in the Ag@TiO2 200p NP solution. The nanoparticle sizes and size distributions were measured using a zeta potential analyzer with dynamic light scattering (DLS). Table 2 summarizes the average dimensions of the synthesized nanoparticles. Ag@TiO2 200p and Ag@TiO2

Towards targeted drugs and next generation of nanomedicines

• Anna Salvati,
• Silvia Giordani and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2026, 17, 598–601, doi:10.3762/bjnano.17.41

• future development. Bioavailability is an important factor for pharmaceutical agents. Here nanoparticles have the great advantage that their physicochemical properties can be largely tailored. A hydrophobic drug can be made more water soluble by linking it to a hydrophilic nanoparticle. However, as with

• affect nanoparticle distribution and reach the target organ [24][27]. Endogenous targeting refers to the capacity of targeting acquired by nanomedicines after administration, upon adsorption on their surface of specific endogenous biomolecules. In fact, while nanomedicines are usually modified to prevent

• first lipid nanoparticle approved in the clinics for RNA delivery (in this case short interfering RNA). It was reported that this nanomedicine reaches the hepatocytes because of the adsorption of apolipoprotein E on its surface once administered, driving accumulation in the liver and promoting

Laser–material interactions in liquids for the synthesis of nanomaterials: current status and perspectives

• Carlos Doñate Buendia,
• Bilal Gökce and
• Leonid V. Zhigilei

Beilstein J. Nanotechnol. 2026, 17, 571–575, doi:10.3762/bjnano.17.38

• generation of surfactant-free, high-purity colloidal nanoparticles. Laser fragmentation in liquids (LFL), in turn, involves the irradiation of colloidal micro- or nanoparticle suspensions with high-intensity pulses above the fragmentation threshold, leading to size reduction through photomechanical or

• changes in atomic structure, enabling defect engineering [20]. The broad materials library accessible through LSPC, combined with the wide range of laser, target, and solvent parameters, creates a complex multidimensional optimization space governing nanoparticle size, internal structure, composition, and

• synthesis productivity [21]. This complexity has driven major efforts within the LSPC community toward elucidating the roles of the solvent environment [6][22], target geometry [23], and irradiation conditions [24] in nanoparticle formation. Advancing these efforts requires a fundamental understanding of

Probing internal continua and atomic ultrafast charge transfer within size-controlled nanoparticles by post-collision interaction in core-hole clock spectroscopy

• Johannes Lütgert,
• Erika Giangrisostomi,
• Nomi L. A. N. Sorgenfrei and
• Alexander Föhlisch

Beilstein J. Nanotechnol. 2026, 17, 505–514, doi:10.3762/bjnano.17.33

• CdSe core, in addition to charge transfer happening solely within the shell, overshadowing possible small effects imposed by quantum confinement. Also, the novel aspect of PCI involving the internal continuum of the respective size-controlled nanoparticle is reflected in the spectral line shape

• difference between the pronounced fluctuations between the relative charge transfer times (Figure 2b) and the smooth trend of the relative asymmetry factors (Figure 4, top). While the asymmetry and the PCI effect are mostly governed by the screening and, thus, the overall electron density of the nanoparticle

• within the nanoparticle. The inset highlights the asymmetric PCI line shape in comparison to the symmetric Voigt profile. Charge transfer times of the core–shell nanoparticles (CdSe core diameter 3.5 nm) with different ZnS double-layer shell thicknesses (1, 2, 7, 11, 15 DL). (a) Raman fraction fR and

Upcycling agroindustrial waste into graphene oxide supports for gold nanoparticles: toward sustainable nanomaterials

• Juan Marcos Castro-Tapia,
• Selene Acosta,
• Hiram Joazet Ojeda-Galván,
• Elsie Evelyn Araujo-Palomo,
• Edgar Giovanni Villabona-Leal and
• Mildred Quintana

Beilstein J. Nanotechnol. 2026, 17, 489–504, doi:10.3762/bjnano.17.32

• as substrates for AuNP photodeposition to evaluate how their surface chemistry governs nanoparticle nucleation and dispersion. Agro-GO@AuNPs composites demonstrate a green, circular-economy approach with promising potential for applications in sensing, diagnostics, energy storage, and separation

• are present throughout the basal plane, not only at edge defects, they provide abundant and readily accessible nucleation sites for AuNP formation, enabling a remarkably uniform nanoparticle distribution. AuNP@Agro-GOX (Figure 10m–p), by comparison, exhibits AuNP deposition predominantly along the

Nanocarrier-integrated multilayer films produced by 3D printing for improved skin adhesion and curcumin photostability

• Thayse Viana de Oliveira,
• Ana Paula Farias Leão,
• Júlia Leão,
• Cesar Liberato Petzhold and
• Ruy Carlos Ruver Beck

Beilstein J. Nanotechnol. 2026, 17, 440–453, doi:10.3762/bjnano.17.30

• nanoparticle aggregation. In addition, the hydrogel network acts as a steric barrier that limits nanoparticle mobility and reduces particle–particle contact during printing and drying. Previous studies have demonstrated the compatibility of SSE 3D printing with nanocarrier systems without significant loss of

Nanoinformatics: spanning scales, systems and solutions

• Iseult Lynch,
• Diego S. T. Martinez,
• Kunal Roy and
• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 423–427, doi:10.3762/bjnano.17.28

• /features governing the cellular uptake were analysed as a basis for programming higher cellular uptake efficiency and better therapeutic response [9]. He et al. used additive AI-based approaches to identify nanoparticle systems for delivering drugs to treat neurodegenerative diseases. Their method

• delivery assays from ChEMBL and 260 nanoparticle cytotoxicity assays from journal articles on which linear discriminant analysis and artificial neural network algorithms were applied. The resulting models were effective as an initial rapid pre-screening of putative nanoparticle-based drug delivery systems

Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

• Valentina I. Gorbacheva,
• Alexey S. Grabovoy,
• Polina S. Marukhina,
• Anastasiia O. Syrocheva and
• Ekaterina P. Kolesova

Beilstein J. Nanotechnol. 2026, 17, 396–422, doi:10.3762/bjnano.17.27

• tissue via the enhanced permeability and retention (EPR) effect, driven by tumor vasculature characteristics [10]. This enhances delivery selectivity, reducing therapeutic doses and impact on healthy tissues. The nanoparticle shell isolates the PS, reducing dark toxicity and systemic phototoxicity [11

• this biomimetic shell increased more than two times the circulation time of the carriers in the bloodstream compared to uncoated PEGylated (polyethylene glycol-coated) nanoparticles, representing the gold standard approach to nanoparticle circulation time. Since then, a wide variety of cell phenotypes

• BNPs is primarily hindered by challenges related to large-scale production, reproducibility, and quality control. The multistep fabrication process, including extraction of cellular membranes and coating of nanoparticle cores, requires careful optimization to ensure stability and consistency [53]. Cell

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids

• Sergio Molina-Prados,
• Nadezhda M. Bulgakova,
• Alexander V. Bulgakov,
• Jesus Lancis,
• Gladys Mínguez Vega and
• Carlos Doñate-Buendia

Beilstein J. Nanotechnol. 2026, 17, 309–342, doi:10.3762/bjnano.17.22

• 10.3762/bjnano.17.22 Abstract Nanoparticle synthesis via pulsed laser ablation in liquids has gained prominence as a versatile and environmentally friendly approach for producing ligand-free colloids with controlled composition, size, and morphology. While pulsed laser ablation in liquids offers

• unparalleled advantages in terms of nanoparticle purity and material versatility, enhancing the size control and productivity require modifications of the standard pulsed laser ablation in liquids technique, such as the incorporation of beam shaping techniques. Recent developments in spatial and temporal beam

• shaping have demonstrated their potential to revolutionise pulsed laser ablation in liquids by enabling more precise energy deposition and modified nanoparticle production dynamics. This review highlights the critical role of beam shaping, encompassing spatial shaping of the beam to influence laser

Durable antimicrobial activity of fabrics functionalized with zeolite ion-exchanged nanomaterials against Staphylococcus aureus and Escherichia coli

• Perla Sánchez-López,
• Kendra Ramirez Acosta,
• Sergio Fuentes Moyado,
• Ruben Dario Cadena-Nava and
• Elena Smolentseva

Beilstein J. Nanotechnol. 2026, 17, 262–274, doi:10.3762/bjnano.17.18

• Científica y de Educación Superior de Ensenada (CICESE), Carretera Ensenada-Tijuana, No. 3918, Zona Playitas, Ensenada 22860, México 10.3762/bjnano.17.18 Abstract Nanoparticle-based functionalization has emerged as an effective strategy to enhance the antimicrobial properties of textiles. In this study

• literature [30], partial nanoparticle loss during washing is commonly reported, with slight leaching occurring after five to ten washing cycles. This loss of nanomaterial may affect its antimicrobial properties; however, the useful life of the textile with antimicrobial properties is extended. The persistent

Gold nanoparticle-decorated reduced graphene oxide as a highly effective catalyst for the selective α,β-dehydrogenation of N-alkyl-4-piperidones

• Brenda Flore Kenyim,
• Mihir Tzalis,
• Marilyn Kaul,
• Robert Oestreich,
• Aysenur Limon,
• Chancellin Pecheu Nkepdep and
• Christoph Janiak

Beilstein J. Nanotechnol. 2026, 17, 218–238, doi:10.3762/bjnano.17.15

• coated with strong ligands that provide initial stability over time, ligand desorption, ligand exchange, or environmental factors such as pH and ionic strength can weaken the protective layer, leading to nanoparticle aggregation or structural degradation [14][15]. An important aspect of expensive noble

• volume. These features provide a more favorable environment for mass transport, reactant diffusion, and nanoparticle dispersion, making rGO a more effective catalyst support, so we expect a better catalytic activity with rGO. In addition to the morphological and textural properties of carbon supports

• gold nanoparticle suspension. The presence of AuNPs was confirmed by the appearance of a localized surface plasmon resonance (LSPR) band in the visible wavelength range, with a maximum absorbance at λmax = 519 nm (Figure 4a). The hydrodynamic radius (HD) by number-weighted distribution of dynamic light

Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• , offering unprecedented opportunities to design and develop nanomaterials with unique, tailored properties. These advances have significantly impacted diverse industrial sectors, including healthcare, energy, environmental remediation, and defence. For instance, nanoparticle-based drug delivery systems have

• and risks associated with specific ENMs [56]. One illustrative application involves modelling nanoparticle–protein interactions, a critical factor in drug delivery systems, where digital twins can accurately predict protein adsorption patterns on nanoparticle surfaces through read-across and

• interpolation from limited experimental datasets [57]. Given that protein corona formation [58] can drastically alter the biodistribution and immunological profile of a nanoparticle, digital twins help pinpoint safer design parameters – such as surface coatings or particle size modifications – which improve

From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers

• Madhuri Yeduvaka,
• Pooja Mittal,
• Ameer Boyalakuntla,
• Usman Bee Shaik,
• Himanshu Sharma,
• Thakur Gurjeet Singh,
• Siva Nageswara Rao Gajula and
• Lakshmi Vineela Nalla

Beilstein J. Nanotechnol. 2026, 17, 159–175, doi:10.3762/bjnano.17.10

• -functionalized GO complex was developed for targeted, controlled release of DOX, enabling selective drug release in acidic intracellular organelles for enhanced cancer treatment [78]. Wang et al. developed a pH-responsive, charge-reversible, and photo-cross-linkable polymer nanoparticle composed of [poly(VBMC-co

• [88]. Jia et al. reported a dual-responsive shape-transformable charge-reversible nanoparticle (DHP@BPP) combined with chemo-photodynamic immunotherapy for treating breast cancer and lung metastasis [81]. Hu et al. developed a hybrid nanocarrier, UPOE, using stimuli-responsive, charge-reversal metal

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• (ethylene glycol) with a fixed concentration different than that used in the present study), examining their cellular uptake at a single time point. The results highlighted that both the type of nanocarrier and the nature of the surface polymer critically influence nanoparticle–cell interactions, including

• proteins detach from the nanoparticle–corona complex under the influence of centrifugal forces. Hence, it is crucial to ascertain the optimal number of washing cycles and centrifugation duration necessary for effectively isolating a particular type of a nanosystem–corona complex from a protein-rich medium

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• . These systems are formed by monoclonal antibodies linked to the lipid bilayer, allowing the nanoparticle to recognize and specifically bind to receptors overexpressed in the membrane of tumor cells. This active functionalization expands the therapeutic potential of liposomes by promoting greater

• h, samples were ultracentrifuged at 18.000 rpm for 10 min. The supernatant was collected and quantified using a micro BCA assay, following the instructions of the manufacturer. The nanoparticle precipitate was re-dispersed in fresh PBS/azide buffer and agitated until the next time point, as

• from [e.g., n = 507] HSPC-50-R-PE control liposomes and [e.g., n = 788] HSPC-IM-R-PE immunoliposomes, which were obtained from six and eight independent AFM images, respectively. 2.4 Fourier transform infrared spectroscopy Drug–nanoparticle interactions were studied by subjecting the previously

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

• , as the investigated polymeric and nanoparticle-filled coatings provide effective protection for stone substrates without significant alteration of their aesthetic properties and with considerable resistance to environmental stressors. However, the criterion of reversibility is not addressed in either

• weathering, especially at higher nanoparticle concentrations. Color stability increased, but a slight darkening and higher surface roughness was spotted, which may limit use for outdoor applications. Overall, the Paraloid–silica nanoparticle coatings effectively enhanced UV, moisture, and biological

Quantitative estimation of nanoparticle/substrate adhesion by atomic force microscopy

• Aydan Çiçek,
• Markus Kratzer,
• Christian Teichert and
• Christian Mitterer

Beilstein J. Nanotechnol. 2026, 17, 1–14, doi:10.3762/bjnano.17.1

• , Leoben, Austria 10.3762/bjnano.17.1 Abstract Understanding nanoparticle adhesion to substrates is the key for their stability and performance in many applications, including energy systems, nanofabrication, catalysis, and electronic devices. In this study, we present a methodology for examining adhesion

• calibration achieved through wedge and diamagnetic lateral force calibrator methods. The work of adhesion was quantified by integrating the obtained lateral forces over the distance moved during manipulation, revealing a non-monotonic dependency on nanoparticle size with maximum adhesion observed for

• strategies for tailoring nanoparticle/substrate interactions. Keywords: adhesion; atomic force microscopy; magnetron sputtering; nanomanipulation; nanoparticles; Introduction Nanoparticles (NPs) are at the forefront of basic research and technological innovation, captivating researchers and engineers from

Internal 3D temperature mapping in biological systems using ratiometric light-sheet imaging and lipid-coated upconversion nanothermometers

• Dannareli Barron-Ortiz,
• Enric Pérez-Parets,
• Rubén D. Cadena-Nava,
• Emilio J. Gualda,
• Jacob Licea-Rodríguez,
• Juan Hernández-Cordero,
• Pablo Loza-Álvarez and
• Israel Rocha-Mendoza

Beilstein J. Nanotechnol. 2025, 16, 2306–2316, doi:10.3762/bjnano.16.159

• range was chosen because (i) it remains below the high-stress temperature threshold of C. elegans (>35 °C) [53] and (ii) it falls within the linear, high-sensitivity region of the NaYF4:Yb/Er nanoparticle thermometric response (20–100 °C) [44]. The black diamonds denote the combined mean values of both

• observation is consistent with Chen et al. [50], who reported internalization of PEI-capped UCNPs into both the gut cavity and intestinal cells. They attributed UCNP uptake within the gut cavity to the favorable nanoparticle dispersibility and cellular internalization to endocytosis, facilitated by

• to the luminal environment rather than intracellular regions, indicating that surface chemistry governs not only nanoparticle uptake but also the spatial interpretation of the thermal maps. This distinction is crucial, as it means our thermal maps report on the temperature within the digestive tract

Chiral plasmonic nanostructures fabricated with circularly polarized light

• Tian Qiao and
• Ming Lee Tang

Beilstein J. Nanotechnol. 2025, 16, 2245–2264, doi:10.3762/bjnano.16.154

• was the amino acid- and peptide-directed seeded growth of gold helicoids [19] (Figure 1d). This was the first time molecular chirality was transferred to plasmonic nanoparticle shapes at the single NC level. However, an atomic-level understanding of how the chiral geometry occurs is still under

• the final NC morphology on the EM field distribution of symmetric nanoparticle precursors [98]. A representative example is the plasmon-mediated synthesis of Au NCs, where the surfactant polyvinylpyrrolidone (PVP) relays warm (not hot) electrons to reduce [101]. Growth was directed by the spatial

• that the sites of Au deposition ( reduction) are the locations of electrons from the nanoparticle transferred via PVP. Researchers made similar observations when electron beam lithography resist was exposed to hot electrons from AuNRs [86]. This study found hydrogen silsesquioxane underwent water

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• -based AuNP colorimetric biosensors In this sensing system, the recognition material is the RNA aptamer, the indicator material is the gold nanoparticle (AuNP), and the sensing signal is colorimetric. The excellent optical-electronic characteristics of AuNPs have been recently considered in point-of-care

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• nanoparticle systems, one functionalized with an oligo(ethylene glycol) ligand, and one functionalized with a mixture of the same with a dimannoside ligand. The dimannoside ligand was chosen to mimic the surface chemistry of viral spike proteins. We characterized the particles by electron microscopy, dynamic

• size average of the dimanno-AuNPs is 30.4 ± 1.1 nm (PDI = 0.29) with a peak at 16.8 ± 0.9 nm. This indicates that the dimannoside coating results in reduced nanoparticle aggregation. Hence, a small number of multimers of the NPs is present in the solution (i.e., stronger particle association). DLS is

• . In other words, the nanoparticle has a non-centrosymmetric environment, which can simply be the presence of the gold surface. The noise-like feature at ~3400 cm−1 is assigned to hydrogen-bonded water as features above 3600 cm−1 should indicate non-hydrogen-bonded water. This is proof that water is

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• systems that combine nanotechnology with biological components (e.g., enzymes), are emerging as environmentally benign solutions in addition to independent nanoparticles. Enzyme–nanoparticle conjugates can target certain plastic polymers, enabling more rapid and targeted breakdown. Iron oxide

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• novel antimicrobial agents. Nanoparticle therapy is emerging as a prominent avenue toward that end [8]. Free radicals represent an important focus in pharmacological research. The severity of oxidative stress, defined as the imbalance between the formation of reactive oxygen/nitrogen species (ROS/RNS

• ). DPPH and nanoparticle mixed solutions were used as sample, while only DPPH solution was used as negative control and ascorbic acid was used as a positive control. The samples were kept in the dark at room temperature for 30 min of incubation, and the change in color was monitored, using a microplate

• their simpler outer membranes compared to those of gram-negative species. The moderate effectiveness of AgSbS2 NCs against E. coli (MIC and MBC; 1.0 mg/mL and 2.0 mg/mL, respectively) also aligns with findings in nanoparticle research where the outer lipopolysaccharide layers of gram-negative bacteria

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• stabilising surface coatings are employed to preserve nanoparticle stability over time. The degree of functionalisation is also a key consideration as surface modifications can enhance solubility, targeting ability, and biocompatibility. Consistent functionalisation is necessary to ensure reproducibility and

• , disruption of cellular membranes, prolonged retention in tissues, and activation of immune responses. These risks highlight the importance of careful nanoparticle design and thorough preclinical evaluation. Biodegradability represents another crucial factor governing the clinical translation of CNMs

• nanoparticle-based drug delivery system. Created in BioRender. Bartkowski, M. (2025) https://BioRender.com/goba3a2. This content is not subject to CC BY 4.0. A selection of key challenges and opportunities associated with the clinical translation of a CNP-based DDS. Created in BioRender. Bartkowski, M. (2025