Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• ether to ≈34% with hexane [3][4][5]. Such variations are commonly influenced by parameters including solvent type, moisture content of the seeds, extraction time, and temperature conditions [6]. The chemical profile of OPS was determined after transesterification to fatty acid methyl esters (FAME

• delivery, effectively combining the functional benefits of P. setacea seed oil with a QbD-guided formulation process. Experimental Materials Seeds of Passiflora setacea BRS Pérola do Cerrado were kindly provided by EMBRAPA (Brasília, DF, Brazil – SisGen Registration Nº. A51F883). n-Hexane was purchased

• 4:1 ratio of n-hexane to P. setacea seeds, following the methodology recommended by the Association of Official Analytical Chemists [55]. Prior to extraction, dried seeds were grounded, placed in folded filter paper, and inserted into the Soxhlet extractor. The extraction was carried out for 6 h at

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• formation of seeds and NP growth represent thermodynamic condensation and electrostatic growth [8]. As demonstrated in [10], the initially formed seeds are prone to interact with the electrons in plasma, attaining negative charge, which attracts positive ions from plasma enabling growth. This occurs unless

• relatively short periods of time, produces spherical NPs that act as seeds during the growth of nonspherical nanostructures. Such approach has been demonstrated in [26] for the production of PbO nanosheets with thickness less than 15 nm by laser ablation of a lead target in water. After the initial stage

• low to melt the particles, the shape transformation can be induced using photochemical processes. However, in this case, the addition of precursors, reducing, and stabilizing agents is required. The pristine NPs that are present in the solution act as seeds, while photoinduced reduction occurs at

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• formulation as a safe and environmentally friendly bioinsecticide for the control of arbovirus vectors. Subaharan et al. (2022) evaluated the larvicidal efficacy of nanoemulsions of Trachyspermum ammi essential oil and its main component, thymol, against Ae. aegypti. The plant, native to India, has seeds rich

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• a magnetic nanoseed concentration of just 0.002 g·L−1, these composites enabled 98% PET extraction, with the separation efficiency largely influenced by the morphology of the magnetic seeds. In addition to ensuring highly efficient magnetic separation of MP particles, this approach significantly

Beyond the bilayer: multilayered hygroscopic actuation in pine cone scales

• Kim Ulrich,
• Max David Mylo,
• Tom Masselter,
• Fabian Scheckenbach,
• Sophia Fischerbauer,
• Martin Nopens,
• Silja Flenner,
• Imke Greving,
• Linnea Hesse and
• Thomas Speck

Beilstein J. Nanotechnol. 2025, 16, 1695–1710, doi:10.3762/bjnano.16.119

• , winged seeds are blocked and protected by the scales under wet conditions and released under dry conditions for wind dispersal. The inspiration provided by such biological motion principles has driven innovation in a variety of fields, including wood elements for weather-responsive and self-forming

• Pinus jeffreyi tree growing in the Botanical Garden in Freiburg im Breisgau, Germany, and were collected from the ground in February 2022, after they had already opened and dispersed most of their seeds. Following collection, the cones were stored in a climate-controlled environment at room temperature

• opened and is releasing its seeds, it would be disadvantageous for the cone scales to “overreact” and close due to every slight rain shower or increase in humidity. In this context, the hysteresis might act as an additional buffer besides the general slow speed of the closure. Delayed closure relative to

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• outer rings of the Bessel beam should be considered when discussing the morphology peculiarities of the formed NPs. At later stages of the process, the outer rings might be also involved in nucleation and growth of nanoparticles by trapping the produced seeds and guiding their aggregation in distinct

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• candidates for surface-enhanced Raman scattering (SERS) due to their strong localized surface plasmon resonance and sharp tip geometry. In this study, AgNPrs were synthesized through a photochemical method by irradiating spherical silver nanoparticle seeds with 10 W green light-emitting diodes (LEDs; 520

• ± 20 nm) for various periods of time up to 72 h. The growth mechanism was investigated through ultraviolet–visible spectroscopy, field-emission scanning electron microscopy, X-ray diffraction, and transmission electron microscopy analyses, confirming the gradual transformation of spherical seeds into

• step of the entire process [3]. During this stage, small silver nanoparticles (seeds) can combine and evolve into anisotropic nanostructures through a chemical process in the presence of hydrogen peroxide (H2O2) and sodium borohydride, commonly referred to as the Mirkin method [4]. Recently

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• °36'45.7" W) after the natural fall of the first ripe fruits. The fruit pulp was manually separated from the seeds and preserved until oil extraction. Bocaiúva oil extraction One kilogram of fresh fruit pulp was placed in an Erlenmeyer flask and extracted with n-hexane (1000 mL) by mechanical agitation for

Chitosan nanocomposite containing rotenoids: an alternative bioinsecticidal approach for the management of Aedes aegypti

• Maria A. A. Bertonceli,
• Vitor D. C. Cristo,
• Ivo J. Vieira,
• Francisco J. A. Lemos,
• Arnoldo R. Façanha,
• Raimundo Braz-Filho,
• Gustavo V. T. Batista,
• Luis G. M. Basso,
• Sérgio H. Seabra,
• Thalya S. R. Nogueira,
• Felipe F. Moreira,
• Arícia L. E. M. Assis,
• Antônia E. A. Oliveira and
• Kátia V. S. Fernandes

Beilstein J. Nanotechnol. 2025, 16, 1197–1208, doi:10.3762/bjnano.16.88

• delivery system for rotenoids isolated from Clitoria fairchildiana seeds, leveraging their larvicidal activity against third-instar larvae of Ae. aegypti. The nanocomposite was synthesized using a controlled ionic gelation method incorporating the TPP-β-CD inclusion complex, which resulted in nanoparticles

• Clitoria fairchildiana seeds with larvicidal activity against third-instar Ae. aegypti larvae. These studies revealed morphological and metabolic changes in the larvae, suggesting that V-ATPase inhibition triggers oxidative stress, resulting in high production of reactive oxygen species (ROS) in the midgut

• isolated and characterized from C. fairchildiana seeds [14]. These compounds exhibited larvicidal activity against third-instar Ae. aegypti larvae, causing morphological changes and metabolic alterations as a result of increased production of ROS in the insect midgut [14]. It is already well-documented in

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

• -particle experiments. These voids form due to local pressure differences caused by energy accumulation in hot spots via photoexcited localized surface plasmons, with the overall melting and particle disintegration resembling an inverted crystal nucleation process, where voids act as seeds and their

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

• levels of the kidney markers urea and creatinine, but there was a decrease in these markers after administration of Cymbopogon proximus suspension, made from ground seeds of the plant and suspended in double-distilled water. Sena-Junior et al. [12] found a reduction in uric acid levels in diabetic rats

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• . Natural hydrogels share some features with synthetic hydrogels, but are more easy to obtain and recycle. One of the main sources of such hydrogels are mucilaginous seeds and fruits, which produce after hydration a gel-like, transparent capsule, the so-called mucilage envelope. Mucilage serves several

• important biological functions, such as supporting seed germination, protecting seeds against pathogens and predators, and allowing the seed to attach to diverse surfaces (e.g., soil or animals). The attachment properties of mucilage are thus responsible for seed dispersal. Mucilage represents a hydrophilic

• the mucilage envelope, primarily in the context of its structure and physical properties, as well as biological functions associated with these properties. Keywords: adhesion; cellulose; friction; hydrogel; mucilage envelope; seeds; Introduction The definition of hydrogels describes them as

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• 21 days than free CUR. Quercetin Quercetin (QCT) is a flavonoid found in many fruits, vegetables, leaves, seeds, and grains. It is particularly abundant in onions, apples, berries, tea, and red wine [84]. This natural polyphenolic compound has gained attention for its diverse therapeutic effects. QCT

• bioactive compound derived from the seeds of Nigella sativa, commonly known as black cumin or black seed. This plant is part of the Ranunculaceae family and has been used for centuries in traditional medicine for its therapeutic properties [93]. THQ exhibits a wide range of therapeutic effects, including

• bioavailability after oral ingestion in male Albino rats compared to native baicalin suspension. These findings highlight the potential of PLHNPs systems in improving the therapeutic potential of poorly soluble compounds like baicalin. Silymarin Silymarin is a flavonoid complex extracted from the seeds of Silybum

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• surface energy values in the following order: [51]. At temperature and saturated vapour pressure values suitable for referential growth directions, ZnO crystals develop from Zn droplets working as nuclei/seeds, which react with oxygen in order to develop characteristic nanostructures. Following

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• with slight modifications [30]. Briefly, in the first step, gold seeds were prepared by mixing CTAB, HAuCl4·3H2O and NaBH4. The seed solution acts as an initiator for synthesizing gold nanorods. In the second step, the growth solution was prepared, consisting of CTAB, AgNO3, HAuCl4·3H2O, HCl, and

• ascorbic acid. A typical synthesis involved the synthesis of CTAB-capped Au seeds of less than 4 nm. Addition to the growth solution in step 2 resulted in the formation of gold nanorods. The seeds were prepared using 200 µL of HAuCl4·3H2O (25 mM) with 2 mL of 0.1 M CTAB at 80 °C, followed by 800 µL freshly

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• diffraction (XRD), and FTIR, respectively, to establish physicochemical properties of the synthesized nanomaterials. Results Synthesis, optical spectroscopy, and zeta potential Anisotropic gold nanoparticles of makura shape were synthesized using seed-mediated approach as shown in Figure 1a. The Au seeds were

• introducing ascorbic acid indicated partial reduction of Au3+ to Au+, since ascorbic acid is a weak reducing agent. The introduction of seeds rapidly changed the colourless solution into blue, indicating complete reduction of Au+ to Au0. This was due to diffusion of Au0 atoms toward the {111} facet of the

• Synthesis of makura-shaped gold nanoparticles Step 1: Synthesis of surfactant-capped gold seeds. Individual surfactant-capped seeds were prepared for the synthesis of different surfactant-capped gold nanomakura. Initially, surfactant-capped gold seeds were synthesized using the available surfactants (CTAB

Electron-induced deposition using Fe(CO)₄MA and Fe(CO)₅ – effect of MA ligand and process conditions

• Hannah Boeckers,
• Atul Chaudhary,
• Petra Martinović,
• Amy V. Walker,
• Lisa McElwee-White and
• Petra Swiderek

Beilstein J. Nanotechnol. 2024, 15, 500–516, doi:10.3762/bjnano.15.45

• thickness regime where the TaNNN signal is still visible. This is a consequence of the larger EAL of CKLL and OKLL electrons as compared to that of TaNNN electrons. Furthermore, AG can contribute to the deposition in EBID after small Fe seeds have formed. This would lead to a higher deposit purity. For

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• .) [17]. Similarly, a concentration of 10 mg/L of ZnO NPs elicited a positive response on the root elongation of Zea mays (corn). However, at a higher concentration of 1000 mg/L, there was an inhibitory effect on the root elongation of both corn and Cucumis sativus (cucumber) seeds, suggesting toxicity

• and water uptake in the presence of Zn [39], or else by accelerating the activity of carbonic anhydrase [2]. Several published information is available on the effect of Zn on photosynthetic pigments of other crops. Nanopriming Triticum aestivum seeds with 10 mg/L of ZnO resulted in a significant

• (SLINTEC). Phytotoxicity experiments on R. sativus grown in an inert solid medium R. sativus was grown in an inert coir medium with three seeds sown in each pot, and weekly treatments were performed as follows [19]: 250 mL of modified Hoagland solution without and with ZnO NPs (0, 1000, 2000, 10,000 mg/L

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• occurs surely through modification of the pristine Al-based hydroxide seeds [28][45][61][70], but even in processes where recrystallization can easily take place. Figure S14 and Table S7 (Supporting Information File 1) summarize the average size and standard deviation values as functions of the

• sharpness and thickness of edges) is closely related to the growth of Al(OH)3-based seeds. Hence, while the issues of the volumetric scale-up can be solved by accurate control of the heating process during the reaction, the drawbacks of the mass scale-up depend on the nature of the involved cations

Solvent-induced assembly of mono- and divalent silica nanoparticles

• Bin Liu,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2023, 14, 52–60, doi:10.3762/bjnano.14.6

• corresponded to a nominal grafting surface density of 0.7 funct./nm2. Then, MMS-functionalized silica NPs (1.8 × 1016 part/L) were used as seeds for the seed-growth emulsion polymerization of styrene (100 g/L) stabilized by a mixture (3 g/L) of Symperonic® NP30 and SDS (5 wt %) and initiated by 1.3 mL of

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

• availability. It is thus environmentally friendly and advantageous [51][52]. Plant parts such as roots, stem, leaves, fruits, flowers, and seeds have been used for the production of CDs. Several low-value plant materials can also be converted into functional materials with excellent biocompatibility by

• , and green synthesis strategy to prepare CDs by using whey (a major dairy waste). NMR analysis showed that during pyrolysis, polymerization of lactose, which is the main component of the green source used, takes place [69]. Sharma et al. reported Nigella sativa seeds for the preparation of CDs that act

A new method for obtaining the magnetic shape anisotropy directly from electron tomography images

• Cristian Radu,
• Ioana D. Vlaicu and
• Andrei C. Kuncser

Beilstein J. Nanotechnol. 2022, 13, 590–598, doi:10.3762/bjnano.13.51

• image consisting only of the local maxima with a minimum height equal to the subtracted value. The local maxima are then labeled and used as seeds for the watershed algorithm [27]. Each particle is reconstructed filling the distance transform image from the voxel with the largest value down but

Zinc oxide nanostructures for fluorescence and Raman signal enhancement: a review

• Ioana Marica,
• Fran Nekvapil,
• Maria Ștefan,
• Cosmin Farcău and
• Alexandra Falamaș

Beilstein J. Nanotechnol. 2022, 13, 472–490, doi:10.3762/bjnano.13.40

• nanorods (NRs) and Au seeds alone. The results showed a stronger SERS signal in the case of Au–ZnO NRs compared to Au nanoscale seeds. The SERS signal enhancement is due to the increased charge transfer effect of ZnO, which is greatly improved by the localized surface plasmon resonance of Au seeds. For the

A non-enzymatic electrochemical hydrogen peroxide sensor based on copper oxide nanostructures

• Irena Mihailova,
• Vjaceslavs Gerbreders,
• Marina Krasovska,
• Eriks Sledevskis,
• Valdis Mizers,
• Andrejs Bulanovs and
• Andrejs Ogurcovs

Beilstein J. Nanotechnol. 2022, 13, 424–436, doi:10.3762/bjnano.13.35

• short time. The particles begin to agglomerate in order to minimize the total surface energy, forming spherical seeds, which, according to the mechanism of dissolution–secondary precipitation [78][80], overgrow with CuO petals, thereby forming 3D structures in solution. Then, under the influence of

Interfacial nanoarchitectonics for ZIF-8 membranes with enhanced gas separation

• Season S. Chen,
• Zhen-Jie Yang,
• Chia-Hao Chang,
• Hoong-Uei Koh,
• Sameerah I. Al-Saeedi,
• Kuo-Lun Tung and
• Kevin C.-W. Wu

Beilstein J. Nanotechnol. 2022, 13, 313–324, doi:10.3762/bjnano.13.26

• ZIF-8 formation rate. As a result, the Zn ions inside the porous substrate were consumed for nanometer-sized ZIF-8 seeds during the initial growing stage, which limited further intergrowth between these seed particles to form continuous ZIF-8 membranes. In addition, thickness of the membranes also