Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• century [3]. They are investigated, for example, regarding drug delivery [4], but they are also parts of actual products, for example, of sensors [5]. All this is based on the ease of synthesis, chemical stability, size tuneability, and unique optical properties [6]. The extreme dependence of the

• tendency. The observed excellent stability of dimanno-AuNPs may be associated with the physical constraint of the dimannoside being present during synthesis and the strong intra-NP hydrogen bonding interactions. These properties are also reflected in the macroscale structures formed upon adsorption

• organic content). Synthesis of gold nanoparticles Gold nanoparticles were synthesized by the Bio Nano Plasmonics Lab at CIC biomaGUNE according to [10]. Both PEG AuNPs and dimanno-AuNPs were obtained by reduction of AuCl4− with BH4− in the presence of the corresponding thiol ligands. For the PEG AuNPs, a

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• inadequate in scale and, in most cases, are not practically useful for real-world applications, especially in the context of advanced technologies. In this regard, more than 85% of nanomaterials synthesis and production processes involve the use of hazardous chemicals such as hydrogen cyanide, sulfuric acid

• , phosphoric acid, nitric acid, hydrochloric acid, sodium hydroxide and potassium hydroxide [21]. To produce nanomaterials, these chemicals are not used in trace amounts but in substantial quantities. During synthesis, nearly 40–50% of these chemicals result in waste, which harms ecological systems by

• contaminating water, air, and soil, even when strict preventive measures are in place. Moreover, the environmental pollution caused by nanomaterials after their lifecycle, along with the chemicals used in their synthesis, is much more hazardous; up to a thousand times more compared to their bulk counterparts

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• language were included. Excluded were marine-only studies, conference abstracts, editorials, and non-peer-reviewed articles. A total of 476 records were identified. Removing duplicates and irrelevant items after title and abstract screening left 127 studies for the final synthesis. In order to facilitate

• . According to Goh et al., these results are especially important for expanding MP remediation technology to industrial applications [43]. Tables 4–6 presents a comprehensive comparison of various nanomaterials explored for MP remediation, detailing their synthesis methods, target pollutants, removal

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• therapeutic approaches [2]. Currently, the assessment of nanotechnology’s impact on the health of both humans and animals, along with its potential in therapy, has become an imperative scientific consideration. Nanotechnology, which is multidisciplinary, is the synthesis of materials and particles with

• , cardiovascular diseases, and diabetes [11][12]. Historically known especially for its antimicrobial properties, silver has been used since ancient times. Silver nanoparticles (AgNPs) are synthesized by different synthesis mechanisms; they are non-toxic to eukaryotic cells, including human cells, but highly toxic

• ) chloride (SbCl3, ≥99.95%), 1-octadecene (ODE, 90%), and ethanol were obtained from Sigma-Aldrich. Toluene was obtained from VWR. 1-Dodecanethiol (1-DDT, C12H26S) was purchased from Alfa Aesar. Rapid synthesis of AgSbS2 NCs Cubic-phase silver antimony sulfide NCs (AgSbS2 NCs) were synthesized by hot

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• regarding toxicity and regulatory hurdles remain major barriers to clinical translation. Current research is therefore focused on standardizing CNM synthesis and characterisation methods, minimizing toxicity, and facilitating regulatory approval. Despite these challenges, CNMs hold substantial promise for

• remains substantial. This perspective uses oncology as a representative model for CNM nanocarriers, owing to cancer’s global health burden and the breadth of available studies [15][16]. Nevertheless, the underlying considerations, including synthesis, physicochemical and biological evaluation, and

• affairs. Achieving these key milestones is critical to developing a safe and effective drug delivery system that can improve the treatment of cancer. The process begins with the synthesis of CNMs tailored to specific size and surface chemistry requirements, using methods such as chemical vapour deposition

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• , chiral materials are crucial in asymmetric synthesis, where the selective production of a desired enantiomer is needed, particularly in pharmaceuticals [7]. Chiral metal-organic frameworks [8] and nanoporous materials [9][10] are emerging as vital components in enantioselective catalysis due to their

• atmosphere. The solvents were dried according to the standard literature and stored under argon. All starting materials used for the synthesis were purchased from commercial sources (Merck or TCI). SIL: In a snap lid vial, dissolve 2.0 mL tetramethoxysilane (2.04 g, 13.4 mmol, 1 equiv) in 1.5 mL methanol

• synthesis, 0.22 mmol of 1,3-bis(triisopropoxysilyl)thiophenol is dissolved in 2 mL of ethanol. 50 µL of a 1 M HCl solution is added under vigorous stirring. After hydrolysis for 1 h, 50 µL of concentrated ammonia was added, and the solution was filled into a syringe and gelled overnight. Aerogels can be

The cement of the tube-dwelling polychaete Sabellaria alveolata: a complex composite adhesive material

• Emilie Duthoo,
• Aurélie Lambert,
• Pierre Becker,
• Carla Pugliese,
• Jean-Marc Baele,
• Arnaud Delfairière,
• Matthew J. Harrington and
• Patrick Flammang

Beilstein J. Nanotechnol. 2025, 16, 1998–2014, doi:10.3762/bjnano.16.138

• hybridization probe synthesis, a second PCR was done with a T7 promoter binding site (5′-GGATCCTAATACGACTCACTATAGG-3′) added to reverse strand PCR primers. After quality and size check by gel electrophoresis, PCR products were purified using the Wizard SV Gel and PCR clean-up system kit (Promega). The purified

• products were used for RNA probe synthesis after sequencing to check if the amplified sequence corresponds to the desired transcript. Localization of the candidates using in situ hybridization A few worms were retrieved from their tubes, and their anterior part was dissected and fixed in a 4

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• Natalie Tarasenka Department of Design, Manufacturing and Engineering Management, University of Strathclyde, 75 Montrose st., G1 1XQ, Glasgow, UK 10.3762/bjnano.16.137 Abstract Shape-and size-controlled synthesis of nanomaterials has been a long-term aim and challenge of modern nanotechnology

• . Despite many synthesis methods are still mainly focused on the production of near-spherical NPs, a number of emerging applications require nanomaterials of nonspherical shape and developed surface, which determine the functional performance of nanostructured devices. Laser ablation in liquids has been

• demonstrated as a clean, simple, and versatile NP synthesis method. However, the conditions of NP formation and growth are favouring the production of spherical NPs. There are fewer studies of shape control during laser ablation. With that in mind, this perspective article represents a view on the current

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• activity and enhanced biocompatibility, achieved through phytochemically mediated synthesis. Conventional nanoparticle production often relies on toxic reagents and energy-intensive processes, posing environmental and clinical challenges. In contrast, green synthesis, using plant extracts, fungi, or

• [4][5][6]. These nanomaterials have been successfully applied in diverse fields, such as medicine, agriculture, cosmetics, electronics, the food industry, and, more recently, dentistry [5][6]. However, conventional chemical and physical synthesis routes often involve toxic organic solvents, high

• energy consumption, and hazardous reducing agents; also, they result in environmental waste, in addition to producing nanoparticles that may be toxic and poorly biocompatible [3][7]. Given the limitations of conventional synthesis methods, the green synthesis of nanoparticles has emerged as a sustainable

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• functionality can be adjusted by changing the metal oxides and linkers, enabling easy synthesis and modification for diverse applications, including MP adsorption [59]. By using ZIF-8 nanocomposite, Pasanen et al. removed 99% of MPs after 1 h. The properties of nanocomposites showed highly porous structures

• strength, and MP size, with sizes below 100 μm normally requiring optimized surface functionalization for effective treatment. The influence of these factors on removal efficiency has also been highlighted in numerous studies, particularly those focusing on the synthesis of magnetic nanomaterials [52][78

• , leading to cellular damage [111]. According to Thirunavukkarasu et al., the interactions between these nanomaterials and other contaminants are not fully understood. While some studies suggest that different synthesis methods can reduce toxicity, they still pose a significant threat to end-users [112

Piezoelectricity of layered double hydroxides: perspectives regarding piezocatalysis and nanogenerators

• Evgeniy S. Seliverstov,
• Evgeniya A. Tarasenko and
• Olga E. Lebedeva

Beilstein J. Nanotechnol. 2025, 16, 1812–1817, doi:10.3762/bjnano.16.124

• organically modified Ni/Co-LDH nanosheets. However, some concerns arise regarding whether the synthesized material reported by the authors can indeed be classified as a Ni/Co-LDH. First, the synthesis was carried out using salts of divalent nickel and divalent cobalt at a Ni/Co ratio of 1:2. In the absence of

• successful synthesis of a hydrotalcite-like Ni/Fe-LDH. The reported cation ratio of Ni/Fe = 0.56 is unlikely to yield a stable LDH phase. Moreover, the presented XRD data begin only at 2θ values of 20°, thereby omitting the (003) reflection at approximately 10°, which is one of the most critical indicators

• stability, reproducibility of synthesis (phase purity, secondary phases, and role of interlayer anions), and durability under repeated operation are critical. From this perspective, several steps could strengthen the further subject studies: (1) reporting standardized, direct piezoelectric measurements (d33

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• permeability, critical factors for effective oral drug delivery, are discussed in detail. Furthermore, nanoparticle synthesis methods that enable controlled release profiles, optimized biodistribution, and improved therapeutic efficacy are also explored. Thus, polymers represent a dynamic platform for

• explores recent advances in the use of polymers for developing oral NPs, focusing on innovative research published in the past decade. It highlights the key characteristics of PNs and their preparation methods. The synthesis processes, chemical structures, and functions of major polymers are detailed

• raises additional concerns regarding the stability and safety of the final product. In light of these challenges, the use of preformed polymers has gained prominence in nanoparticle synthesis, offering a more straightforward and biocompatible alternative particularly suited for pharmaceutical

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• ) selection, synthesis, and technical details of aptamers and their applications are described in detail in the article. The exclusion criteria are: (1) review, letter, news; (2) comment of a conference or seminar; (3) case report; or (4) irrelevant research topic of the article. Eventually, 17 original

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• significant challenges for both synthesis and in operando characterization. In particular, photon-hungry techniques like APXPS require the high brilliance provided by fourth-generation synchrotron sources to probe such dilute systems. From a synthetic perspective, stabilizing isolated metal atoms against

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• containing immunomodulators and checkpoint inhibitors to achieve a synergistic effect and consequently expand the clinical potential of nanotechnology containing natural products. Patent KR20220169108 was discussed in the article published by Dhandapani et al., which addresses the synthesis, physicochemical

• , microemulsion and inverse microemulsion, hydrothermal method, seeding, sonoelectrodeposition, and coprecipitation can be implemented for the synthesis of nanoparticles [98]. In the context of cancer treatment, nanoparticles promote enhanced biocompatibility, reduced toxicity, and increased stability and

• light, synthesis in reverse micelles, and condensation processes [148]. Gold nanoparticles have great benefits for cancer and immunotherapy, providing increased efficiency and effectiveness by acting as immune regulators, enhancing the delivery of antitumor drugs, and improving biocompatibility

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• synthesis, hybrid system integration, and machine learning optimization. Together, these approaches aim to establish a comprehensive, scalable, and environmentally safe solution for the remediation of MPs in wastewater systems. Keywords: artificial intelligence; membrane technology; microplastic

• synthesis and characterisation techniques have enabled the detection of materials at the nanoscale, unlocking new opportunities across various streams. In the field of water treatment, nanotechnology is gaining wide attention due to its enhanced efficiency, effectiveness, affordability, and durability. The

• techniques for the removal of MPs. Nanoparticle-based removal Advancements in characterization and synthesis techniques have enabled the manipulation of materials at the nanoscale, leading to innovations across various domains, including energy, electronics, and biomedical applications. Figure 5 depicts

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• deposition, electrophoretic deposition, and electrochemical deposition are extensively utilized for the synthesis of TiO2 nanowire arrays, owing to their advantageous physical properties and varied applications [14][15]. Our previous study accomplished the precipitation of TiO2 nanowire arrays, with

• without further purification. Deionized water was used for all the experiments. Synthesis of TiO2 nanowires on carbon cloth The synthesis follows basically our previous study but on a larger scale [16]. In brief, a 5 cm × 10 cm piece of carbon cloth (CC) underwent three cleaning cycles using ethyl alcohol

• Discussion Microstructure and morphology of photocatalysts Figure 1a shows schematically the synthesis of TiO2 nanowires on an activated carbon cloth substrate. When the carbon cloth is immersed in the Ti–H2O2 precursor solution maintained at 80 °C, first, the carbon cloth surface is activated, and, second

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• certain progress in this field, there is still a need for reliable and controlled synthesis methods for silicon-based nanostructures. Nowadays, pulsed laser ablation in liquids (PLAL) has been recognized as a general and important route for the synthesis of nanoparticles (NPs) with tuned optical and

• the preparation of non-spherical NPs are the fabrication of semiconductor nanowires such as hybrid CdS [20] and ZnS nanowires [21]. Si nanowires can also be prepared by laser ablation [4][5]. However, the synthesis is typically performed in gaseous atmosphere, and the developed approaches require high

• laser beam energy distribution (Gauss, Bessel, or annular) for the synthesis of silicon nanomaterials of different shapes by laser ablation in a liquid. The advantages of laser beams with Bessel and annular profiles were demonstrated earlier in the fields of material processing, such as microdrilling

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• reagents or solvent systems [39][40]. DESs are formed through hydrogen bonding between two solid components resulting in eutectic liquids having a melting point lower than those of the individual components [41][42]. They offer advantages such as simple synthesis, low cost, and broad applications in

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• )carbodiimide (EDC) coupling [5] and “click” chemistry reactions [6] have proven to be effective tools in the synthesis of novel functional materials. Carbodiimide coupling is an invaluable tool for the coupling of carboxylic acids to amines, through amide bond formation. The combination of EDC and N

• IONPs, which can be coupled to azides through the CuAAC, with no detectable cross-reactivity. At this point, it may be tempting to label the conjugation reaction as a success. However, an important step in the synthesis has been neglected: We have not provided evidence that the binding of PPA is through

• were performed at 4000g, for 3 min, at rt. Synthesis of 3,4-DHBA exchanged nanoparticles (IONP-3,4-DHBA) Oleic acid-capped iron oxide nanoparticles (IONP-OA) were prepared in accordance with a previously established method, described in more detail elsewhere [50][72]. Ligand exchange was carried out

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• Nanoparticles in their pure colloidal form synthesized by laser-assisted processes such as laser ablation/fragmentation/irradiation/melting in liquids have attained much interest from the scientific community because of their specialties like facile synthesis, ultra-high purity, biocompatibility, colloidal

• Raman spectroscopy (SERS) substrates, and solar cells. In this review article, we describe different methods of nanocolloidal synthesis using laser-assisted processes and corresponding thin film fabrication methods, particularly those utilized for device fabrication and characterization. The four

• sections start with an introduction to the common laser-assisted synthesis for nanocolloids and different methods of thin film fabrication using these nanocolloids followed by devices fabricated and characterized for applications including photovoltaics, photodetectors, catalysis, photocatalysis

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• enhancement factor of 1.15 × 106, enabling detection limits down to 10−9 M. These findings demonstrate that green LED-mediated synthesis provides a simple, environmentally friendly route to fabricate high-yield AgNPrs with superior SERS capabilities, suitable for ultrasensitive chemical and biological sensing

• applications. Keywords: light-emitting diodes (LEDs); photochemical synthesis; silver nanoprisms; surface-enhanced Raman scattering (SERS); trisodium citrate; Introduction Anisotropic silver nanoparticles (ASNPs) have attracted increasing attention from research groups worldwide due to their potential

• ] SERS substrates by impregnating them with silver nanostructures. While many efforts have been devoted to the synthesis of AgNPrs and evaluation of their SERS activity, limited studies have focused on the SERS performance of photochemically synthesized AgNPrs, particularly in 4-mercaptobenzoic acid (4

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• areas by analyzing topics, keywords, and relevant studies on “MPs and BC” through bibliometric methods, (ii) synthesize existing literature on major research themes, including modified biochar synthesis and its role in remediating contaminated environmental matrices, and (iii) expand the assessment of

• . This underscores the necessity of interdisciplinary research integrating material science, agriculture, and microbiology in biochar–MP–plant interactions. Three primary research trajectories emerge from the keyword analysis: Investigating how different biochar synthesis methods influence

• removal efficiency in wastewater treatment applications. Biochar synthesis techniques and functional optimization Biochar synthesis The synthesis methods for biochar, as illustrated in Figure 4, encompass traditional hydrolysis techniques and modified approaches utilizing materials such as magnetic

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• Lei Wang Shizhe Li Kexin Xu Wenjun Li Ying Li Gang Liu Institute of Chemical and Industrial Bioengineering, Jilin Engineering Normal University, Changchun 130052, Jilin, People’s Republic of China Jilin Science and Technology Innovation Center of Green Synthesis and New Materials Research and

• lifespan of the membranes. The widely used antimicrobial nanoparticles can be categorized based on their composition and properties as follows: metallic nanoparticles, carbon-based nanomaterials, oxide nanoparticles, and composite nanomaterials. Zheng’s group used an in situ synthesis method to embed AgNPs

• into polyacrylonitrile (PAN) nanofibers, the fabricated Ag/PAN-TFN FO membrane demonstrated excellent antibacterial activity against Escherichia coli and Staphylococcus aureus with improved water flux and salt rejection. The in situ synthesis method ensures a uniform distribution of AgNPs within the

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• , antibiotics can bind to multiple sites in the cell wall peptidoglycans (PGNs), resulting in inhibition of PGN synthesis, perturbation of the cell membrane integrity and cell death [46][47]. In Gram-negative bacteria, lipopolysaccharides interact electrostatically with positively charged antibiotics [48] and

• during synthesis, making them adaptable for different drug delivery needs [59][60][61]. Surface modifications, such as the incorporation of polyethylene glycol (PEG) or specific targeting ligands, are commonly used to enhance liposome circulation time and promote targeted drug delivery. These

• that the pore size can be precisely controlled during synthesis, MSiNPs are widely applied for delivering drugs to targeted sites, particularly in cancer and infectious diseases [88][89]. In addition, MSiNPs can be further enhanced by surface modifications, such as the attachment of polyethyleneimine