Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• Synthesis of the DOX-loaded GNR nanocomplex In the present study, DOX-conjugated GNRs and hyperthermia were employed as a treatment strategy for HCC cells. First, GNRs were synthesized according to the well-known seed-mediated growth method [25] with a slight modification reported in our previous work [26

• laser irradiation, as evidenced by the rapid temperature increase on the nanocarrier surface under 808 nm laser exposure for 2 min. A high cytotoxicity was observed with DOX-PSS-GNRs after NIR laser irradiation, in contrast to DOX alone. The GNRs could proficiently produce hyperthermia by converting NIR

Transient coating of γ-Fe₂O₃ nanoparticles with glutamate for its delivery to and removal from brain nerve terminals

• Konstantin Paliienko,
• Artem Pastukhov,
• Michal Babič,
• Daniel Horák,
• Olga Vasylchenko and
• Tatiana Borisova

Beilstein J. Nanotechnol. 2020, 11, 1381–1393, doi:10.3762/bjnano.11.122

• neurological disorders. Excessive ambient glutamate concentration is a characteristic feature of, among others, stroke, brain trauma, epilepsy, and seizure development. Superparamagnetic γ-Fe2O3 nanoparticles are very promising in targeted drug delivery, cancer therapy, diagnostics, and hyperthermia treatment

• due to their magnetism and chemical stability [9][10][11][12][13]. Among a variety of other nanoparticles, superparamagnetic iron oxide nanoparticles are used for magnetic resonance imaging in cancer theranostics and magnetic hyperthermia [9][10][11][14]. Controlled magnetic fields can lead to induced

Magnetic-field-assisted synthesis of anisotropic iron oxide particles: Effect of pH

• Andrey V. Shibaev,
• Petr V. Shvets,
• Darya E. Kessel,
• Roman A. Kamyshinsky,
• Anton S. Orekhov,
• Sergey S. Abramchuk,
• Alexei R. Khokhlov and
• Olga E. Philippova

Beilstein J. Nanotechnol. 2020, 11, 1230–1241, doi:10.3762/bjnano.11.107

• environmental benigness [4][5][6][7][8]. These nanomaterials can be exploited in a variety of applications, including magnetic data storage [9], magnetic resonance imaging (MRI) [6][10][11][12], hyperthermia [6][13][14][15], magnetic separation [16], targeted drug delivery [6][16][17][18][19], lithium-ion

• properties and a larger length-scale of the locally induced magnetic field in comparison to nanospheres with a similar volume, providing an enhanced MRI contrast [11][19][23], higher specific adsorption rate in magnetic hyperthermia [13], and better separation efficiency in magnetic separation of immune

Influence of the magnetic nanoparticle coating on the magnetic relaxation time

• Mihaela Osaci and
• Matteo Cacciola

Beilstein J. Nanotechnol. 2020, 11, 1207–1216, doi:10.3762/bjnano.11.105

• Abstract Colloidal systems consisting of monodomain superparamagnetic nanoparticles have been used in biomedical applications, such as the hyperthermia treatment for cancer. In this type of colloid, called a nanofluid, the nanoparticles tend to agglomeration. It has been shown experimentally that the

• relaxation time; nanoparticle coating; numerical simulation; stochastic Langevin dynamics method; superparamagnetic nanoparticles; Introduction One of the most important biomedical applications of colloidal magnetic nanoparticle systems is magnetic hyperthermia applied as an alternative for cancer treatment

• generating heat. This heat increases the tumour cell temperature which leads to cell death [1][2][3][4]. Iron-oxide magnetic nanoparticles, in particular magnetite (Fe3O4) and maghemite (γ-Fe2O3), have been intensely studied in the context of magnetic hyperthermia applications. These nanoparticles can be

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• NIR-induced hyperthermal effect on the bacteria elimination, the hyperthermia could also trigger a release of more Ag+ ions as a synergic effect. New methods for detecting and eliminating antibiotic-resistant, Gram-negative bacteria were developed by conjugating the phages to gold nanorods, whose

• thiol monolayers, aiming to impart a different wettability to the surfaces [63]. It was verified that the photothermal features and the consequent hyperthermia-derived antibacterial effects were not affected by the thiol layers, which enable the eradication of at least 99.99% of the bacterial strains

• of the antibacterial ions can act synergistically with the NIR-induced hyperthermia to eliminate the bacteria and biofilm. Silver nanoparticles that absorb in the NIR spectral range can be used for the photothermal elimination of bacteria and this physical effect can be enhanced by both the release

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• behave like one magnetic unit, rotating in the presence of a magnetic field without retaining the magnetism after the magnetic field is removed [17]. This property makes SPIONs good candidates for MRI, and also for a type of thermic treatment of cancer, called localized hyperthermia. There are also other

• pool (ferritin and transferrin) for normal metabolic activities [20]. In localized hyperthermia, SPIONs generate heat by constantly aligning to an alternating magnetic field. This heat is rapidly transferred to the surrounding cancerous tissue in which proteins denature and, consequently, cells become

• , dendrimers, albumin, silicones, liposomes, poloxamer, poly-ʟ-lysine, sugars, or polyethylene glycol (PEG) [27][28][29][30][31][32][33]. Hyperthermia treatment for cancer therapy is still under scrutiny. It shows great potential due to the property of SPIONs to produce local heat when placed under an

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• ]. This was possible thanks to the co-encapsulated cypate [36] or IR780 [106], which could induce hyperthermia through NIR irradiation. In [36], a 9,10-diphenylanthracene derivative is loaded while in [106] it is covalently linked to the methacrylate backbone together with the photosensitizer. It might

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• is simultaneously employed as a contrast agent in magnetic resonance imaging (MRI) and for local heating therapy using magnetic particle hyperthermia [33]. In vitro hyperthermia tests showed efficiency in inoculating mouse breast cancer cells. Another study reports the use of alendronate-coated gold

Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields

• Nikolai A. Usov,
• Ruslan A. Rytov and
• Vasiliy A. Bautin

Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221

• SAR values of the order of 400–500 W/g can be obtained in a rotating magnetic field with a frequency f = 400 kHz and a moderate magnetic field amplitude H0 = 100 Oe. Keywords: magnetic hyperthermia; magnetic nanoparticles; numerical simulation; rotating magnetic field; specific absorption rate

• ; viscous liquid; Introduction Magnetic nanoparticles are promising materials in various areas of biomedicine [1][2][3][4], such as magnetic resonance imaging [5][6][7], targeted drug delivery [8][9][10], and magnetic hyperthermia [11][12][13][14][15][16][17][18][19][20]. Iron oxide nanoparticles are most

• frequently used in biomedicine due to their biocompatibility, biodegradability and relatively high saturation magnetization. In magnetic hyperthermia [2][3][11][12][13][14][15][16][17][18][19][20] magnetic nanoparticles are directly introduced into a tumor and are exposed to an alternating magnetic field

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• whose features are used in many technologies, from magnetic information storage to ferrofluids or nanoscale drug-delivery systems and magneto-assisted hyperthermia cancer treatments [65]. Single SPION detection with 10 nm accuracy was shown by bulk diamond NV center magnetometry combining spin

Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• have been investigated for hyperthermia and magnetic resonance imaging owing to their increased stability in aqueous media and biocompatibility [27][28]. An even stronger anchoring agent consisting of a dendron structure bearing a bisphosphonate polar head provided increased colloidal stability in

Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

• Natalia E. Gervits,
• Andrey A. Gippius,
• Alexey V. Tkachev,
• Evgeniy I. Demikhov,
• Sergey S. Starchikov,
• Igor S. Lyubutin,
• Alexander L. Vasiliev,
• Vladimir P. Chekhonin,
• Maxim A. Abakumov,
• Alevtina S. Semkina and
• Alexander G. Mazhuga

Beilstein J. Nanotechnol. 2019, 10, 1964–1972, doi:10.3762/bjnano.10.193

• genomic and proteomic analysis [5], for drug delivery [6], as magnetic resonance imaging (MRI) contrast agents [7], and for magnetic hyperthermia [8]. This wide variety of applications is due to the unique combination of magnetic, optical and chemical properties that are characteristic of MNPs. However

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• doping on structure, morphology and magnetic properties of CoxFe3−xO4 samples was investigated. In particular, we examined the interparticle interactions in the samples by δm graphs and Henkel plots that have not been reported before in literature. Finally, we studied the hyperthermia properties and

• observed that the heat efficiency of soft Fe3O4 is about 4 times larger than that of hard CoFe2O4 ferrite, which was attributed to the high coercive field of samples compared with the external field amplitude. Keywords: anisotropy; cobalt; ferrite; Henkel plots; hyperthermia therapy; nanoparticles

• ) and especially magnetic hyperthermia therapy, which is one of the efficient and new approaches for cancer treatment [4][15]. When magnetic NPs concentrated in tumor tissue are exposed to an ac magnetic field, the electromagnetic energy is converted into thermal energy, and the generated heat is used

On the relaxation time of interacting superparamagnetic nanoparticles and implications for magnetic fluid hyperthermia

• Andrei Kuncser,
• Nicusor Iacob and
• Victor E. Kuncser

Beilstein J. Nanotechnol. 2019, 10, 1280–1289, doi:10.3762/bjnano.10.127

• superparamagnetic regime in the presence of interparticle dipolar interactions is considered. The direct implications of such interactions for magnetic fluid hyperthermia therapy through susceptibility loss mechanisms give rise to an indirect method for their study via specific absorption rate measurements

• static and time-dependent micromagnetic simulations. Keywords: magnetic hyperthermia; magnetic nanoparticles; magnetic relaxation time; micromagnetic simulation; Introduction Magnetic relaxation phenomena in nanoparticulate systems are under intensive investigation today, especially due to their

• nanoparticulate contrasting agents on proton relaxivity [7][8][9]) and cancer therapy (through magnetic fluid hyperthermia therapy [10][11]). The efficiency of the magnetic nanoparticles (MNPs) in a colloidal system to convert the energy of AC magnetic fields into temperature increments is of high importance for

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• , targeting tumor sites using an external magnetic field, MRI contrast agents, or magnetic hyperthermia. Under physiological conditions, the nanoparticle surface is exposed to the action of biomolecules, oxygen, peroxides, and radicals, which changes particle properties and behavior. Moreover, Fe2+ ions can

Co-doped MnFe₂O₄ nanoparticles: magnetic anisotropy and interparticle interactions

• Bagher Aslibeiki,
• Parviz Kameli,
• Hadi Salamati,
• Giorgio Concas,
• Maria Salvador Fernandez,
• Alessandro Talone,
• Giuseppe Muscas and
• Davide Peddis

Beilstein J. Nanotechnol. 2019, 10, 856–865, doi:10.3762/bjnano.10.86

• of potential applications, e.g., from catalysis [5] and microwaves applications [6] to biomedicine, such as MRI [7], hyperthermia [8], and drug delivery [7][9] applications. Nanometer-sized magnetic materials exhibit different properties compared their bulk counterparts [10][11]. Below a critical

• different magnetic anisotropy opens interesting perspectives for applications in biomedical fields (e.g., MRI, drug delivery, hyperthermia) [20][21] and energy harvesting. Experimental Synthesis Several samples consisting of manganese ferrite nanoparticles with different cobalt doping, i.e., Mn1−xCoxFe2O4

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• NIR CW irradiation corresponded to a typical hyperthermia of cells [51][52]. To investigate the role of folate targeting in photothermal cancer therapy, folate-positive HeLa cells were incubated with AuNR-PDA-R123-folate or AuNR-PDA-R123-PEG nanocomposites of different concentrations. After incubation

Heating ability of magnetic nanoparticles with cubic and combined anisotropy

• Nikolai A. Usov,
• Mikhail S. Nesmeyanov,
• Elizaveta M. Gubanova and
• Natalia B. Epshtein

Beilstein J. Nanotechnol. 2019, 10, 305–314, doi:10.3762/bjnano.10.29

• ; Introduction Magnetic hyperthermia [1][2][3] is a promising therapeutic method that can be used in combination with chemotherapy or radiotherapy for cancer treatment. Iron oxide nanoparticles are among the materials most popular for application in biomedicine due to their biocompatibility, biodegradability [4

• ] and sufficiently high saturation magnetization [5]. However, only nanoparticles with a high specific absorption rate (SAR) in an alternating external magnetic field are suitable for magnetic hyperthermia. Therefore, a significant number of recent experimental studies [6][7][8][9][10][11][12][13][14

• nanoparticles in biological media to quantitatively predict their heating efficiency in magnetic nanoparticle hyperthermia. In this respect we would like to stress that the behavior of an assembly of magnetic nanoparticles in viscous liquids and biological media is different [2][3]. It has been proved recently

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• strategy to increase the PTT efficiency is the combination with magnetic hyperthermia [28], or with chemotherapy [29][30]. Using a one-pot synthesis strategy, we developed Au@alendronate NPs for a combined application of the antitumor activity of alendronate and an efficient gold-mediated PTT. We further

Size-selected Fe₃O₄–Au hybrid nanoparticles for improved magnetism-based theranostics

• Maria V. Efremova,
• Yulia A. Nalench,
• Eirini Myrovali,
• Anastasiia S. Garanina,
• Ivan S. Grebennikov,
• Polina K. Gifer,
• Maxim A. Abakumov,
• Marina Spasova,
• Makis Angelakeris,
• Alexander G. Savchenko,
• Michael Farle,
• Natalia L. Klyachko,
• Alexander G. Majouga and
• Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

• and agarose phantom systems) showed the best characteristics for application as contrast agents in magnetic resonance imaging and for local heating using magnetic particle hyperthermia. Due to the octahedral shape and the large saturation magnetization of the magnetite particles, we obtained an

• extraordinarily high r2-relaxivity of 495 mM−1·s−1 along with a specific loss power of 617 W·gFe−1 and 327 W·gFe−1 for hyperthermia in aqueous and agarose systems, respectively. The functional in vitro hyperthermia test for the 4T1 mouse breast cancer cell line demonstrated 80% and 100% cell death for immediate

• hyperthermia; magnetic resonance imaging; nanomagnetism; theranostics; Introduction Biocompatible magnetite nanoparticles (NPs) are anticipated to provide new noninvasive therapies and early diagnostics for previously incurable diseases using a single, so-called “theranostics” platform [1][2][3]. The magnetic

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• from MRI contrast agents to drug-delivery systems, local heat sources in magnetic hyperthermia therapy of tumors, magnetically assisted transfection of cells, and magnetic field-assisted separation techniques. Let us to note that MRI is already widely used in human medicine and several iron-oxide-based

Fabrication of photothermally active poly(vinyl alcohol) films with gold nanostars for antibacterial applications

• Mykola Borzenkov,
• Maria Moros,
• Claudia Tortiglione,
• Serena Bertoldi,
• Nicola Contessi,
• Silvia Faré,
• Angelo Taglietti,
• Agnese D’Agostino,
• Piersandro Pallavicini,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2018, 9, 2040–2048, doi:10.3762/bjnano.9.193

• on glass slides [8]. In this case, the efficient photothermal response of the monolayers resulted in a local hyperthermia effect that was capable of killing bacteria in Staphylococcus aureus biofilms [8]. Therefore, the motivation of the present work lies on the assumption that the incorporation of

Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

• Sašo Gyergyek,
• David Pahovnik,
• Ema Žagar,
• Alenka Mertelj,
• Rok Kostanjšek,
• Miloš Beković,
• Marko Jagodič,
• Heinrich Hofmann and
• Darko Makovec

Beilstein J. Nanotechnol. 2018, 9, 1613–1622, doi:10.3762/bjnano.9.153

• magnetically induced hyperthermia. In this study, a simple and scalable route for preparing nanocomposites with a high, uniform loading of magnetic nanoparticles is presented. The magnetic iron-oxide nanoparticles were functionalized with a methacrylate-based monomer that copolymerized in a toluene solution

• values for the specific power loss when subjected to alternating magnetic fields, giving this material great potential for the magnetically induced hyperthermia-based treatment of cancer. Keywords: magnetic hyperthermia; magnetic properties; nanocomposites; superparamagnetic; Introduction Magnetic iron

• coercivity in the absence of an external magnetic field [1][2]. Their colloidal suspensions are vital in a variety of technological [3] and biomedical applications [4], such as contrast agents in magnetic resonance imaging (MRI) [5][6], targeted drug delivery [6] and magnetic hyperthermia based on the

Surface characterization of nanoparticles using near-field light scattering

• Eunsoo Yoo,
• Yizhong Liu,
• Chukwuazam A. Nwasike,
• Sebastian R. Freeman,
• Brian C. DiPaolo,
• Bernardo Cordovez and
• Amber L. Doiron

Beilstein J. Nanotechnol. 2018, 9, 1228–1238, doi:10.3762/bjnano.9.114

• on the waveguide. Superparamagnetic iron oxide nanoparticles (SPIOs) have been extensively studied due to their unique chemical, physical, thermal, and mechanical applications in areas such as cell labeling, tissue repair, drug delivery, magnetic resonance (MR) contrast, and hyperthermia [25][26][27

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

• ]. Generally, biocompatible magnetite (Fe3O4), iron oxide, iron sulfides and maghemite (Fe2O3) are synthesized using magnetotactic bacteria [156][157] that helps in targeted cancer treatment via magnetic hyperthermia, magnetic resonance imaging (MRI), DNA analysis and gene therapy [158]. Moreover, surface